SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		4 / 6 LYS A 165
VAL A 107
ILE A 163
ARG A 147
 None
 1.06A 1iepA-5o6kA:
undetectable		 1iepA-5o6kA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		3 / 3 ASP A 102
PHE A 152
VAL A 107
 None
 0.75A 1kijB-5o6kA:
undetectable		 1kijB-5o6kA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		4 / 7 LEU A 104
GLU A  98
LEU A  99
TYR A 125
 None
 1.23A 2w8yA-5o6kA:
undetectable		 2w8yA-5o6kA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		5 / 12 LEU A 168
PHE A 120
LEU A 243
VAL A  77
VAL A 239
 None
 0.90A 3gwxB-5o6kA:
undetectable		 3gwxB-5o6kA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		4 / 5 ASP A 199
ASP A 196
ASP A  66
ARG A 122
 None
None
PO4  A 301 (-4.6A)
None
 1.34A 3naiA-5o6kA:
undetectable		 3naiA-5o6kA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		5 / 9 ARG A 235
GLY A  69
GLY A  68
ARG A 178
GLY A  72
 None
PO4  A 301 (-3.4A)
PO4  A 301 (-3.8A)
None
PO4  A 304 ( 4.1A)
 1.41A 4h2fA-5o6kA:
undetectable		 4h2fA-5o6kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		5 / 9 ARG A 235
GLY A  69
GLY A  68
ARG A 178
GLY A  72
 None
PO4  A 301 (-3.4A)
PO4  A 301 (-3.8A)
None
PO4  A 304 ( 4.1A)
 1.33A 4h2gA-5o6kA:
undetectable		 4h2gA-5o6kA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		4 / 7 TYR A 206
TYR A 210
LEU A  14
PHE A  12
 None
 1.21A 4yv5A-5o6kA:
undetectable		 4yv5A-5o6kA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		4 / 6 ARG A 122
SER A  90
ASP A  66
GLY A  69
 None
None
PO4  A 301 (-4.6A)
PO4  A 301 (-3.4A)
 1.03A 5cdqA-5o6kA:
undetectable
5cdqC-5o6kA:
undetectable
5cdqD-5o6kA:
2.0		 5cdqA-5o6kA:
11.21
5cdqC-5o6kA:
11.21
5cdqD-5o6kA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		4 / 6 HIS A 124
ALA A  64
LEU A 168
TYR A 225
 None
PO4  A 301 ( 4.8A)
None
None
 0.99A 5igiA-5o6kA:
undetectable		 5igiA-5o6kA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		5 / 12 TYR A 103
ILE A 214
THR A 217
GLN A  63
SER A 123
 None
 1.43A 5l8oB-5o6kA:
undetectable		 5l8oB-5o6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5o6k POLYPHOSPHATE:AMP
PHOSPHOTRANSFERASE
(Meiothermus
ruber) 		4 / 8 ASP A 196
ARG A 122
GLU A 126
VAL A 131
 None
 1.28A 6fbvD-5o6kA:
undetectable		 6fbvD-5o6kA:
undetectable