SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 6 GLU A 247
TRP A 116
THR A 124
TYR A  99
 None
 1.45A 1qvuA-5o77A:
undetectable		 1qvuA-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 6 LEU A 285
TRP A 116
THR A 124
TYR A 118
 None
 1.28A 1qvuA-5o77A:
undetectable		 1qvuA-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 7 TYR A 264
THR A 232
THR A 228
SER A 226
 None
 1.18A 1tv8B-5o77A:
undetectable		 1tv8B-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 7 GLY A 180
TYR A 220
ASN A 179
ASP A 143
 None
 1.02A 2g72B-5o77A:
undetectable		 2g72B-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 6 ARG A 134
ASP A  90
THR A 132
ASP A 100
 None
 0.97A 2j2pE-5o77A:
undetectable
2j2pF-5o77A:
undetectable		 2j2pE-5o77A:
18.37
2j2pF-5o77A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 4 GLY A  55
TYR A  54
GLY A  80
ASP A  90
 None
C8E  A 404 (-3.4A)
None
None
 0.67A 3kl3A-5o77A:
undetectable		 3kl3A-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		3 / 3 ASP A  33
GLU A  20
GLY A  19
 None
 0.65A 3w9tA-5o77A:
undetectable		 3w9tA-5o77A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 7 SER A  31
ASP A  32
THR A  25
THR A  34
 None
 0.96A 4ac9C-5o77A:
undetectable		 4ac9C-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 6 SER A  31
ASP A  32
THR A  25
THR A  34
 None
 1.00A 4acbC-5o77A:
undetectable		 4acbC-5o77A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 8 ASP A 114
ARG A 126
GLU A 290
GLU A 102
 None
TRS  A 401 ( 2.9A)
None
None
 1.08A 4gkhF-5o77A:
undetectable		 4gkhF-5o77A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		3 / 3 TYR A 317
HIS A 238
ARG A 275
 None
 1.15A 4htfA-5o77A:
undetectable		 4htfA-5o77A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		5 / 8 LYS A  16
TYR A  36
ARG A  75
ASP A 106
ARG A 126
 None
None
C8E  A 403 (-3.1A)
TRS  A 401 ( 4.4A)
TRS  A 401 ( 2.9A)
 0.80A 4kr4C-5o77A:
39.0		 4kr4C-5o77A:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		6 / 10 LYS A  16
TYR A  36
ARG A  75
TYR A  95
THR A 119
ARG A 126
 None
None
C8E  A 403 (-3.1A)
None
TRS  A 401 (-4.5A)
TRS  A 401 ( 2.9A)
 0.66A 4kr8C-5o77A:
41.4		 4kr8C-5o77A:
63.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5o77 OMPK35
(Klebsiella
pneumoniae) 		4 / 8 ILE A 262
ALA A 248
VAL A 223
ASP A 114
 None
 0.89A 6hu9a-5o77A:
undetectable
6hu9e-5o77A:
undetectable		 6hu9a-5o77A:
undetectable
6hu9e-5o77A:
undetectable