SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		3 / 3 MET A 269
LEU A 272
SER A 273
 None
 0.62A 1ee2A-5o8fA:
undetectable		 1ee2A-5o8fA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		5 / 12 VAL A  12
VAL A  87
LEU A  81
LEU A  83
LEU A  91
 None
 1.37A 1mx1E-5o8fA:
undetectable		 1mx1E-5o8fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		5 / 10 SER A 211
PHE A 212
TYR A  57
LEU A  59
GLY A 177
 NAG  A 502 (-3.9A)
None
None
None
None
 1.19A 2b8jB-5o8fA:
undetectable		 2b8jB-5o8fA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 5 ARG A 129
THR A 131
LEU A  59
ALA A  45
 None
 1.46A 2e1qD-5o8fA:
undetectable		 2e1qD-5o8fA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		5 / 12 PHE A 212
ALA A 135
ILE A  47
ILE A  44
THR A 132
 None
 0.99A 2rlcA-5o8fA:
undetectable		 2rlcA-5o8fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		3 / 3 VAL A 241
ASN A 410
TRP A 414
 None
 1.00A 2y00B-5o8fA:
3.1		 2y00B-5o8fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 6 LEU A  79
ILE A  77
PRO A 120
VAL A 111
 None
 1.17A 2ygoA-5o8fA:
undetectable		 2ygoA-5o8fA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		5 / 12 MET L  34
ARG L  72
ASN L  77
VAL L  79
ALA L  98
 None
 0.91A 3qxtA-5o8fL:
21.5		 3qxtA-5o8fL:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		6 / 12 LEU L   4
ALA L  24
MET L  34
VAL L  79
ALA L  98
TYR L 114
 None
 0.79A 3qxtB-5o8fL:
22.0		 3qxtB-5o8fL:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		6 / 12 LEU L   4
MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
 None
 0.61A 3qxtB-5o8fL:
22.0		 3qxtB-5o8fL:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		6 / 12 MET L  34
ARG L  72
ASN L  74
VAL L  79
ALA L  98
TYR L 114
 None
 0.64A 3qxvA-5o8fL:
21.6		 3qxvA-5o8fL:
68.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		5 / 12 MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
 None
 0.53A 3qxvB-5o8fL:
21.6		 3qxvB-5o8fL:
68.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		5 / 11 MET L  34
ARG L  72
ASN L  74
VAL L  79
ALA L  98
 None
 0.44A 3qxvC-5o8fL:
21.7		 3qxvC-5o8fL:
68.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		5 / 12 MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
 None
 0.62A 3qxvD-5o8fL:
21.4		 3qxvD-5o8fL:
68.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5o8f NANOBODY NB25
(Lama
glama) 		5 / 12 MET L  34
ARG L  72
VAL L  79
ALA L  98
TYR L 114
 None
 0.55A 3qxvE-5o8fL:
18.1		 3qxvE-5o8fL:
68.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5o8f NANOBODY NB25
(Lama
glama) 		4 / 6 ASN L  77
ASP L  73
GLY L  55
PRO L  32
 None
 1.06A 4l1aB-5o8fL:
undetectable		 4l1aB-5o8fL:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 7 LEU A 208
GLY A 171
GLY A 170
ALA A 174
 None
 0.74A 4yjiA-5o8fA:
undetectable		 4yjiA-5o8fA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		3 / 3 ARG A 277
ASP A 290
TYR A 285
 None
 0.80A 4yo9B-5o8fA:
1.8		 4yo9B-5o8fA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 5 GLU A  52
TYR A 143
TYR A 228
ARG A 216
 None
 1.36A 5mthA-5o8fA:
1.6
5mthB-5o8fA:
2.5		 5mthA-5o8fA:
21.94
5mthB-5o8fA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 5 GLU A  52
TYR A 143
TYR A 228
ARG A 216
 None
 1.34A 5mthH-5o8fA:
1.3
5mthL-5o8fA:
2.5		 5mthH-5o8fA:
21.94
5mthL-5o8fA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 5 GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.34A 6cduA-5o8fA:
28.6
6cduB-5o8fA:
20.8		 6cduA-5o8fA:
48.09
6cduB-5o8fA:
48.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 7 GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.36A 6cduA-5o8fA:
28.6
6cduE-5o8fA:
3.8		 6cduA-5o8fA:
48.09
6cduE-5o8fA:
48.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 6 GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.48A 6cduB-5o8fA:
20.8
6cduC-5o8fA:
21.2		 6cduB-5o8fA:
48.09
6cduC-5o8fA:
48.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		5 / 7 ILE A 242
GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.41A 6cduC-5o8fA:
21.2
6cduD-5o8fA:
20.9		 6cduC-5o8fA:
48.09
6cduD-5o8fA:
48.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		5 / 8 ILE A 242
GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.55A 6cduG-5o8fA:
28.5
6cduH-5o8fA:
4.7		 6cduG-5o8fA:
48.09
6cduH-5o8fA:
48.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 7 GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.31A 6cduH-5o8fA:
4.7
6cduI-5o8fA:
21.0		 6cduH-5o8fA:
48.09
6cduI-5o8fA:
48.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 5 GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.41A 6cduI-5o8fA:
21.0
6cduJ-5o8fA:
5.7		 6cduI-5o8fA:
48.09
6cduJ-5o8fA:
48.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5
(Homo
sapiens) 		4 / 5 GLN A  65
THR A  60
HIS A 107
GLY A 127
 None
 1.23A 6gbnC-5o8fA:
undetectable		 6gbnC-5o8fA:
21.77