SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 ILE A   9
PHE A   8
ALA A 149
LEU A 154
LEU A  20
 None
 1.19A 1og5B-5o8rA:
undetectable		 1og5B-5o8rA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 6 TYR A 179
ASP A 211
PHE A 215
ARG A 214
 None
 1.20A 2a3bB-5o8rA:
undetectable		 2a3bB-5o8rA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 GLY A 338
GLY A 198
SER A 166
ARG A 170
PHE A 173
 NAP  A 502 (-3.5A)
NAP  A 502 (-3.4A)
None
None
None
 1.14A 2okcA-5o8rA:
undetectable		 2okcA-5o8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		3 / 3 SER A 159
TYR A 339
HIS A 340
 None
FAD  A 501 ( 4.5A)
None
 0.77A 2r2vD-5o8rA:
undetectable		 2r2vD-5o8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 6 THR A 385
GLU A 382
PHE A 377
ILE A 370
 None
 1.21A 2w98B-5o8rA:
undetectable		 2w98B-5o8rA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 7 LEU A  20
VAL A 153
GLY A  10
GLY A 155
 None
 0.73A 2wd9A-5o8rA:
undetectable		 2wd9A-5o8rA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 8 LEU A  20
VAL A 153
GLY A  10
GLY A 155
 None
 0.73A 2wd9B-5o8rA:
undetectable		 2wd9B-5o8rA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 11 VAL A 294
LEU A 219
ILE A 222
SER A 197
LYS A 269
 None
None
None
NAP  A 502 (-3.1A)
NAP  A 502 (-2.9A)
 1.24A 3bjwB-5o8rA:
undetectable		 3bjwB-5o8rA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 11 VAL A 294
LEU A 219
ILE A 222
SER A 197
LYS A 269
 None
None
None
NAP  A 502 (-3.1A)
NAP  A 502 (-2.9A)
 1.27A 3bjwE-5o8rA:
undetectable		 3bjwE-5o8rA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 VAL A 294
LEU A 219
ILE A 222
SER A 197
LYS A 269
 None
None
None
NAP  A 502 (-3.1A)
NAP  A 502 (-2.9A)
 1.28A 3bjwF-5o8rA:
undetectable		 3bjwF-5o8rA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		3 / 3 GLU A 312
GLU A 331
TRP A 307
 None
 1.13A 3hrdA-5o8rA:
undetectable
3hrdE-5o8rA:
undetectable
3hrdF-5o8rA:
undetectable		 3hrdA-5o8rA:
12.24
3hrdE-5o8rA:
12.24
3hrdF-5o8rA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 8 TYR A 217
PHE A 215
TYR A 179
ILE A 204
 None
 0.71A 3ihzB-5o8rA:
undetectable		 3ihzB-5o8rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 VAL A  33
SER A 136
VAL A 376
ALA A 149
TYR A   6
 None
 1.01A 3qxvB-5o8rA:
undetectable		 3qxvB-5o8rA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 5 ASP A  61
LEU A  74
PRO A  57
PHE A  93
 None
 1.12A 3s3vA-5o8rA:
undetectable		 3s3vA-5o8rA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 8 TYR A 217
PHE A 215
TYR A 179
ILE A 204
 None
 0.87A 3uqbA-5o8rA:
undetectable		 3uqbA-5o8rA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 PHE A 346
ILE A 350
VAL A  33
LEU A 152
TRP A 147
 FAD  A 501 (-4.5A)
None
None
None
None
 1.30A 4qynA-5o8rA:
undetectable		 4qynA-5o8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		4 / 8 GLY A  10
ILE A   5
GLY A  32
PHE A  34
 None
 0.52A 5alcL-5o8rA:
undetectable		 5alcL-5o8rA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		3 / 3 TYR A 229
LYS A 265
LYS A 269
 None
NAP  A 502 (-3.9A)
NAP  A 502 (-2.9A)
 1.34A 5dbyA-5o8rA:
undetectable		 5dbyA-5o8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS
(Erwinia
amylovora) 		5 / 12 ILE A   9
LEU A  35
ILE A   5
CYH A 131
HIS A 150
 None
 0.96A 6a5zL-5o8rA:
undetectable		 6a5zL-5o8rA:
23.33