SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 SER A 101
ILE A 304
ILE A  66
TYR A  61
TRP A  58
 None
 1.35A 1osvB-5o8xA:
undetectable		 1osvB-5o8xA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 SER A 101
ILE A 304
ILE A  66
TYR A  61
TRP A  58
 None
 1.36A 1ot7A-5o8xA:
undetectable		 1ot7A-5o8xA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 SER A 101
ILE A 304
ILE A  66
TYR A  61
TRP A  58
 None
 1.34A 1ot7B-5o8xA:
undetectable		 1ot7B-5o8xA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 190
LEU A 167
ALA A 179
GLY A 199
LEU A  85
 None
 1.08A 2a58A-5o8xA:
undetectable
2a58B-5o8xA:
undetectable		 2a58A-5o8xA:
18.42
2a58B-5o8xA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 190
LEU A 167
ALA A 179
GLY A 199
LEU A  85
 None
 1.07A 2a58B-5o8xA:
undetectable
2a58C-5o8xA:
undetectable		 2a58B-5o8xA:
18.42
2a58C-5o8xA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 190
LEU A 167
ALA A 179
GLY A 199
LEU A  85
 None
 1.08A 2a58D-5o8xA:
undetectable
2a58E-5o8xA:
undetectable		 2a58D-5o8xA:
18.42
2a58E-5o8xA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 10 ILE A  99
VAL A 201
ALA A 202
ILE A 284
VAL A 283
 None
 1.02A 2nnjA-5o8xA:
undetectable		 2nnjA-5o8xA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		4 / 6 THR A 158
ASP A 120
ASN A  39
ASP A   6
 None
 1.24A 2okcA-5o8xA:
undetectable		 2okcA-5o8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 162
GLY A 163
ALA A 164
MET A 171
ARG A 132
 None
None
None
CAC  A 402 (-4.2A)
None
 1.39A 2xh9A-5o8xA:
undetectable		 2xh9A-5o8xA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 244
LEU A 241
GLN A 259
VAL A 217
THR A 232
 None
 1.16A 2yloA-5o8xA:
undetectable		 2yloA-5o8xA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 145
ALA A 147
PHE A  35
GLN A  30
PHE A  26
 None
 1.10A 3b2rA-5o8xA:
undetectable		 3b2rA-5o8xA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 248
SER A 240
MET A 239
GLU A 228
ALA A 230
 None
 1.25A 3sxjA-5o8xA:
undetectable		 3sxjA-5o8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 248
SER A 240
MET A 239
GLU A 228
ALA A 230
 None
 1.25A 3sxjB-5o8xA:
undetectable		 3sxjB-5o8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 248
SER A 240
MET A 239
GLU A 228
ALA A 230
 None
 1.46A 3t7sC-5o8xA:
undetectable		 3t7sC-5o8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 146
GLY A 166
LEU A 167
PHE A 170
ALA A 179
 None
 1.08A 3tbgD-5o8xA:
undetectable		 3tbgD-5o8xA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 245
PRO A 279
VAL A 261
ASP A 257
 None
 1.16A 3ufnA-5o8xA:
undetectable
3ufnB-5o8xA:
undetectable		 3ufnA-5o8xA:
21.30
3ufnB-5o8xA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 11 ARG A 233
VAL A 267
ILE A 272
ILE A 222
MET A 292
 None
 0.81A 4dz2A-5o8xA:
undetectable
4dz2B-5o8xA:
undetectable		 4dz2A-5o8xA:
19.47
4dz2B-5o8xA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 11 MET A 292
ARG A 233
VAL A 267
ILE A 272
ILE A 222
 None
 0.81A 4dz2A-5o8xA:
undetectable
4dz2B-5o8xA:
undetectable		 4dz2A-5o8xA:
19.47
4dz2B-5o8xA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		4 / 6 MET A 171
ILE A  99
ILE A  98
VAL A  94
 CAC  A 402 (-4.2A)
None
None
None
 0.95A 4olmA-5o8xA:
undetectable		 4olmA-5o8xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  54
GLN A  57
GLU A  60
 None
 0.89A 4tvtA-5o8xA:
undetectable		 4tvtA-5o8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 146
GLY A 166
PHE A 170
ALA A 179
SER A 200
 None
 1.28A 4wnuC-5o8xA:
undetectable		 4wnuC-5o8xA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 136
ARG A 137
LEU A 122
ALA A 162
 None
 1.04A 6b89B-5o8xA:
undetectable		 6b89B-5o8xA:
19.79