SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 12 LEU A 112
LEU A 158
VAL A 162
ALA A 192
PHE A 214
None
1.26A 1gseA-5o96A:
undetectable
1gseA-5o96A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
4 / 5 ASP A 203
GLY A 200
PRO A 175
ALA A 176
None
SAM  A 501 (-2.9A)
SAM  A 501 (-3.4A)
None
0.78A 2aohA-5o96A:
undetectable
2aohA-5o96A:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 12 GLY A 196
GLY A 200
LEU A 219
LEU A 224
THR A 226
ALA A 229
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.47A 2egvA-5o96A:
22.8
2egvA-5o96A:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 12 LEU A 173
GLY A 196
GLY A 200
LEU A 219
THR A 226
ALA A 229
SAM  A 501 (-4.2A)
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.94A 2egvA-5o96A:
22.8
2egvA-5o96A:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 12 GLY A 196
GLY A 200
LEU A 219
LEU A 224
THR A 226
ALA A 229
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.49A 2egvB-5o96A:
22.7
2egvB-5o96A:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 12 LEU A 173
GLY A 196
GLY A 200
LEU A 219
THR A 226
ALA A 229
SAM  A 501 (-4.2A)
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.92A 2egvB-5o96A:
22.7
2egvB-5o96A:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
4 / 5 LEU A 193
LEU A 112
MET A  94
CYH A 108
None
1.18A 2oaxD-5o96A:
undetectable
2oaxD-5o96A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
4 / 6 ILE A  88
TRP A 133
LEU A 152
ILE A 109
None
1.02A 2q83B-5o96A:
undetectable
2q83B-5o96A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 9 ILE A 195
GLY A 196
GLY A 200
SER A 218
LEU A 224
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
None
SAM  A 501 (-4.5A)
0.88A 2qmmA-5o96A:
11.3
2qmmA-5o96A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 11 ILE A 195
GLY A 196
GLY A 200
SER A 218
LEU A 219
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
None
SAM  A 501 (-4.9A)
0.96A 2qmmA-5o96A:
11.2
2qmmB-5o96A:
10.9
2qmmA-5o96A:
25.40
2qmmB-5o96A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 11 ILE A 195
GLY A 196
GLY A 200
SER A 218
LEU A 224
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
None
SAM  A 501 (-4.5A)
0.86A 2qmmA-5o96A:
11.2
2qmmB-5o96A:
10.9
2qmmA-5o96A:
25.40
2qmmB-5o96A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 10 ILE A 231
LEU A 234
VAL A 106
GLY A 105
GLN A  99
None
1.18A 2wd9C-5o96A:
undetectable
2wd9C-5o96A:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 9 GLY A 196
GLY A 200
LEU A 219
LEU A 224
ALA A 229
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
0.66A 2z0yA-5o96A:
21.1
2z0yA-5o96A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 9 GLY A 196
GLY A 200
LEU A 219
LEU A 224
ALA A 229
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
0.62A 2z0yB-5o96A:
20.6
2z0yB-5o96A:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 9 ILE A 195
GLY A 196
SER A 218
LEU A 219
LEU A 224
None
SAM  A 501 (-4.1A)
None
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
1.00A 3ai9X-5o96A:
10.8
3ai9X-5o96A:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 11 ILE A 195
GLY A 196
LEU A 224
THR A 226
ALA A 229
None
SAM  A 501 (-4.1A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.20A 3kw2A-5o96A:
26.2
3kw2A-5o96A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 11 ILE A 195
GLY A 196
LEU A 224
THR A 226
ALA A 229
None
SAM  A 501 (-4.1A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.25A 3kw2B-5o96A:
26.0
3kw2B-5o96A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
4 / 7 ILE A  82
GLN A 238
GLY A 241
VAL A 186
None
0.99A 4a3uB-5o96A:
undetectable
4a3uB-5o96A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 10 ILE A 206
GLY A 196
GLY A 200
PHE A 214
SER A 210
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
None
None
0.88A 4fakA-5o96A:
9.6
4fakA-5o96A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
4 / 7 ARG A  35
GLY A  31
ILE A  56
GLU A  37
None
1.05A 4g0vA-5o96A:
undetectable
4g0vA-5o96A:
16.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
10 / 11 LEU A 173
PRO A 175
GLU A 198
GLY A 200
SER A 218
LEU A 219
VAL A 223
ARG A 225
THR A 226
ALA A 229
SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.0A)
SAM  A 501 (-2.9A)
None
SAM  A 501 (-4.9A)
SAM  A 501 (-4.4A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.00A 5o96A-5o96A:
41.3
5o96B-5o96A:
36.9
5o96A-5o96A:
100.00
5o96B-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 9 ILE A 195
GLY A 196
GLY A 200
LEU A 219
LEU A 224
ALA A 229
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
0.28A 5o96A-5o96A:
41.3
5o96B-5o96A:
36.9
5o96A-5o96A:
100.00
5o96B-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 9 LEU A 173
ILE A 195
GLY A 196
GLY A 200
LEU A 219
ALA A 229
SAM  A 501 (-4.2A)
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-3.3A)
0.94A 5o96A-5o96A:
41.3
5o96B-5o96A:
36.9
5o96A-5o96A:
100.00
5o96B-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 9 LEU A 173
PRO A 175
ILE A 195
GLY A 196
GLY A 200
LEU A 219
SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
1.29A 5o96A-5o96A:
41.3
5o96B-5o96A:
36.9
5o96A-5o96A:
100.00
5o96B-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
7 / 10 HIS A 174
ILE A 195
GLY A 196
GLY A 200
VAL A 223
LEU A 224
ALA A 229
None
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
0.41A 5o96C-5o96A:
37.5
5o96D-5o96A:
37.2
5o96C-5o96A:
100.00
5o96D-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
7 / 10 LEU A 173
HIS A 174
ILE A 195
GLY A 196
GLY A 200
LEU A 224
ALA A 229
SAM  A 501 (-4.2A)
None
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
0.74A 5o96C-5o96A:
37.5
5o96D-5o96A:
37.2
5o96C-5o96A:
100.00
5o96D-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
8 / 9 LEU A 173
HIS A 174
PRO A 175
GLY A 196
SER A 218
VAL A 223
LEU A 224
ARG A 225
SAM  A 501 (-4.2A)
None
SAM  A 501 (-3.4A)
SAM  A 501 (-4.1A)
None
SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-4.8A)
0.69A 5o96E-5o96A:
37.4
5o96F-5o96A:
38.3
5o96E-5o96A:
100.00
5o96F-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 10 LEU A 173
PRO A 175
GLU A 198
GLY A 200
VAL A 223
ARG A 225
SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.0A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.4A)
SAM  A 501 (-4.8A)
1.28A 5o96E-5o96A:
37.4
5o96F-5o96A:
38.3
5o96E-5o96A:
100.00
5o96F-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
8 / 10 LEU A 173
PRO A 175
GLY A 196
GLY A 200
VAL A 223
LEU A 224
ARG A 225
ALA A 229
SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.3A)
0.59A 5o96E-5o96A:
37.4
5o96F-5o96A:
38.3
5o96E-5o96A:
100.00
5o96F-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 10 PRO A 175
GLY A 199
VAL A 223
LEU A 224
ALA A 229
SAM  A 501 (-3.4A)
None
SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
0.68A 5o96E-5o96A:
37.4
5o96F-5o96A:
38.3
5o96E-5o96A:
100.00
5o96F-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 10 GLY A 199
VAL A 223
LEU A 224
THR A 226
ALA A 229
None
SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.73A 5o96G-5o96A:
38.0
5o96H-5o96A:
37.1
5o96G-5o96A:
100.00
5o96H-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
8 / 10 LEU A 173
GLY A 196
GLY A 200
LEU A 219
VAL A 223
LEU A 224
THR A 226
ALA A 229
SAM  A 501 (-4.2A)
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.65A 5o96G-5o96A:
38.0
5o96H-5o96A:
37.1
5o96G-5o96A:
100.00
5o96H-5o96A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 10 LEU A 173
PRO A 175
GLY A 196
GLY A 200
LEU A 219
SAM  A 501 (-4.2A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
1.08A 5o96G-5o96A:
38.0
5o96H-5o96A:
37.1
5o96G-5o96A:
100.00
5o96H-5o96A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 12 ILE A 195
GLY A 196
GLY A 200
LEU A 219
LEU A 224
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
0.50A 5twjA-5o96A:
9.3
5twjA-5o96A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 10 ILE A 195
GLY A 196
GLY A 200
LEU A 219
LEU A 224
None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
0.46A 5twjB-5o96A:
9.2
5twjB-5o96A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
6 / 10 GLY A 196
GLY A 200
LEU A 219
LEU A 224
THR A 226
ALA A 229
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.71A 5vm8B-5o96A:
30.4
5vm8B-5o96A:
36.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
5 / 10 GLY A 199
LEU A 219
LEU A 224
THR A 226
ALA A 229
None
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
0.83A 5vm8B-5o96A:
30.4
5vm8B-5o96A:
36.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
4 / 5 TYR A 184
VAL A 186
LEU A 237
SER A 218
None
1.24A 6a7pA-5o96A:
undetectable
6a7pA-5o96A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila)
4 / 8 LEU A 217
VAL A 191
LEU A 193
ILE A  82
None
0.79A 6cb4A-5o96A:
undetectable
6cb4A-5o96A:
19.28