SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 GLU W 581
GLU W 580
GLU W 577
GLU W 578
 None
 0.89A 1knyA-5o9gW:
undetectable
1knyB-5o9gW:
undetectable		 1knyA-5o9gW:
10.37
1knyB-5o9gW:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP W 761
HIS W 756
ASP W 764
 None
 0.85A 1nw5A-5o9gW:
undetectable		 1nw5A-5o9gW:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE W 691
LEU W 687
LYS W 708
GLY W 735
 None
 0.84A 1os6A-5o9gW:
undetectable		 1os6A-5o9gW:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG W 597
GLN W 410
ASN W 536
LEU W 418
 None
 1.26A 2nyrA-5o9gW:
undetectable		 2nyrA-5o9gW:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU W 690
ILE W 733
SER W 732
GLY W 728
 None
 1.01A 2otfA-5o9gW:
undetectable		 2otfA-5o9gW:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS W 661
MET W 697
MET W 723
 None
 1.21A 2vj1A-5o9gW:
undetectable		 2vj1A-5o9gW:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ARG W 563
GLY W 397
ILE W 540
ASP W 513
VAL W 512
 None
None
None
ADP  W1501 ( 4.0A)
None
 1.22A 2zznA-5o9gW:
2.2		 2zznA-5o9gW:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE W 213
CYH W 246
PHE W 249
 None
 1.11A 3cr5X-5o9gW:
undetectable		 3cr5X-5o9gW:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA W 448
ILE W 371
GLY W 373
THR W 408
VAL W 412
 None
None
None
ADP  W1501 (-3.6A)
None
 0.88A 3el4A-5o9gW:
undetectable		 3el4A-5o9gW:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU W 299
GLY W 301
THR W 302
 None
 0.53A 3iazA-5o9gW:
undetectable		 3iazA-5o9gW:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE W 558
GLU W 527
SER W 523
ARG W 537
 None
 1.35A 3jx1A-5o9gW:
undetectable
3jx1B-5o9gW:
undetectable		 3jx1A-5o9gW:
14.56
3jx1B-5o9gW:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 SER W 523
ARG W 537
PHE W 558
GLU W 527
 None
 1.38A 3n5tA-5o9gW:
undetectable
3n5tB-5o9gW:
undetectable		 3n5tA-5o9gW:
14.72
3n5tB-5o9gW:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE W 691
LEU W 687
LYS W 708
GLY W 735
 None
 0.74A 3selX-5o9gW:
undetectable		 3selX-5o9gW:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG W 517
LEU W 434
PRO W 433
GLU W 493
 None
 1.23A 3vlnA-5o9gW:
undetectable		 3vlnA-5o9gW:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ILE W 549
ILE W 583
TYR W 582
GLU W 581
 None
 0.82A 4a99D-5o9gW:
undetectable		 4a99D-5o9gW:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE W 558
GLU W 527
SER W 523
ARG W 537
 None
 1.39A 4capA-5o9gW:
undetectable
4capB-5o9gW:
undetectable		 4capA-5o9gW:
14.56
4capB-5o9gW:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 GLN W 424
ASN W 353
GLN W 508
ASN W 536
 None
 1.37A 4d1yA-5o9gW:
undetectable
4d1yB-5o9gW:
undetectable		 4d1yA-5o9gW:
9.07
4d1yB-5o9gW:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP W 464
ASP W 317
ASP W 498
ASN W 459
 None
 1.14A 4feuB-5o9gW:
undetectable		 4feuB-5o9gW:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP W 464
ASP W 317
ASP W 498
ASN W 459
 None
 1.16A 4fewB-5o9gW:
undetectable		 4fewB-5o9gW:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP W 464
ASP W 317
ASP W 498
ASN W 459
 None
 1.04A 4fexB-5o9gW:
undetectable		 4fexB-5o9gW:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU W 819
THR W 785
SER W 718
VAL W 714
 None
 0.73A 4ik7B-5o9gW:
undetectable		 4ik7B-5o9gW:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU W 489
MET W 437
ASP W 450
 None
 0.79A 4j7xB-5o9gW:
undetectable		 4j7xB-5o9gW:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLU W 611
THR W 610
HIS W 712
LEU W 707
 None
 0.90A 4pfjA-5o9gW:
undetectable		 4pfjA-5o9gW:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP W 401
LYS W 599
LEU W 606
 None
 1.04A 4ptjA-5o9gW:
undetectable		 4ptjA-5o9gW:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		6 / 9 ARG W 186
LEU W 214
TRP W 217
THR W 226
TRP W 227
LEU W 239
 None
 0.83A 4x3uA-5o9gW:
7.9		 4x3uA-5o9gW:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_2
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ARG W 186
LEU W 214
THR W 226
TRP W 227
LEU W 239
 None
 0.83A 4x3uB-5o9gW:
8.2		 4x3uB-5o9gW:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_2
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ARG W 186
LEU W 214
TRP W 217
THR W 226
TRP W 227
 None
 0.56A 4x3uB-5o9gW:
8.2		 4x3uB-5o9gW:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE W 558
GLU W 527
SER W 523
ARG W 537
 None
 1.46A 5fj3A-5o9gW:
undetectable
5fj3B-5o9gW:
undetectable		 5fj3A-5o9gW:
14.72
5fj3B-5o9gW:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASN W 452
TYR W 469
CYH W 455
 None
 1.05A 5lsuB-5o9gW:
undetectable		 5lsuB-5o9gW:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 SER W 523
ARG W 537
PHE W 558
GLU W 527
 None
 1.45A 5uo8A-5o9gW:
undetectable
5uo8B-5o9gW:
undetectable		 5uo8A-5o9gW:
13.99
5uo8B-5o9gW:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE W 558
GLU W 527
SER W 523
ARG W 537
 None
 1.43A 5vv7A-5o9gW:
undetectable
5vv7B-5o9gW:
undetectable		 5vv7A-5o9gW:
14.72
5vv7B-5o9gW:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR W1192
VAL W1257
LEU W1261
SER W1132
 None
 1.28A 6a7pA-5o9gW:
undetectable		 6a7pA-5o9gW:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 SER W 523
ARG W 537
PHE W 558
GLU W 527
 None
 1.45A 6av6A-5o9gW:
undetectable
6av6B-5o9gW:
undetectable		 6av6A-5o9gW:
4.34
6av6B-5o9gW:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE W 558
GLU W 527
SER W 523
ARG W 537
 None
 1.42A 6av6C-5o9gW:
undetectable
6av6D-5o9gW:
undetectable		 6av6C-5o9gW:
4.34
6av6D-5o9gW:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU W 376
GLN W 380
LYS W 446
 ADP  W1501 (-4.1A)
None
None
 0.95A 6exiB-5o9gW:
2.8		 6exiB-5o9gW:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU W 376
GLN W 380
LYS W 446
 ADP  W1501 (-4.1A)
None
None
 0.96A 6exiA-5o9gW:
2.8		 6exiA-5o9gW:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY W 728
LEU W 731
VAL W 745
PHE W 767
 None
 0.76A 6h7lA-5o9gW:
undetectable		 6h7lA-5o9gW:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP W 755
ARG W 313
GLU W 283
GLU W 288
 None
 1.13A 6mn5E-5o9gW:
undetectable		 6mn5E-5o9gW:
4.35