SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
4 / 7 THR A 164
PRO A 163
GLY A  22
ASP A  26
None
0.90A 2ddwB-5o9iA:
undetectable
2ddwB-5o9iA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 10 VAL A   2
HIS A  93
ASP A 170
VAL A  65
VAL A  51
None
1.38A 3fhjA-5o9iA:
undetectable
3fhjA-5o9iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 10 VAL A   2
HIS A  93
ASP A 170
VAL A  65
VAL A  51
None
1.38A 3fhjB-5o9iA:
undetectable
3fhjB-5o9iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 10 VAL A   2
HIS A  93
ASP A 170
VAL A  65
VAL A  51
None
1.38A 3fhjC-5o9iA:
undetectable
3fhjC-5o9iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 9 VAL A   2
HIS A  93
ASP A 170
VAL A  65
VAL A  51
None
1.38A 3fhjD-5o9iA:
undetectable
3fhjD-5o9iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 10 VAL A   2
HIS A  93
ASP A 170
VAL A  65
VAL A  51
None
1.38A 3fhjE-5o9iA:
undetectable
3fhjE-5o9iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 9 VAL A   2
HIS A  93
ASP A 170
VAL A  65
VAL A  51
None
1.38A 3fhjF-5o9iA:
undetectable
3fhjF-5o9iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 9 VAL A   2
HIS A  93
ASP A 170
VAL A  65
VAL A  51
None
1.40A 3fi0H-5o9iA:
undetectable
3fi0H-5o9iA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 10 PHE A 152
VAL A 187
PHE A  54
TYR A  58
PHE A 150
None
1.03A 3r6wA-5o9iA:
undetectable
3r6wB-5o9iA:
undetectable
3r6wA-5o9iA:
19.67
3r6wB-5o9iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
5 / 10 VAL A 187
PHE A  54
TYR A  58
PHE A 150
PHE A 152
None
0.92A 3r6wA-5o9iA:
undetectable
3r6wB-5o9iA:
undetectable
3r6wA-5o9iA:
19.67
3r6wB-5o9iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
5o9i TRANSCRIPTION
INITIATION FACTOR
IIB,TRANSCRIPTION
INITIATION FACTOR
IIB

(Methanocaldococc
us
vulcanius)
4 / 7 VAL A  49
GLU A  12
ILE A 180
VAL A  51
None
0.88A 5jh7C-5o9iA:
undetectable
5jh7C-5o9iA:
20.10