SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5o9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		3 / 3 MET A 182
LEU A 185
SER A 186
 None
EDO  A 412 ( 4.0A)
None
 0.53A 1ee2A-5o9wA:
undetectable		 1ee2A-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		3 / 3 ASP A 116
THR A 119
GLU A  14
 None
None
EDO  A 408 ( 4.2A)
 0.73A 1pj7A-5o9wA:
undetectable		 1pj7A-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		5 / 11 THR A 286
PHE A 211
LEU A 244
VAL A 276
PHE A  88
 None
 1.44A 1q23J-5o9wA:
undetectable		 1q23J-5o9wA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		5 / 10 THR A 286
PHE A 211
LEU A 244
VAL A 276
PHE A  88
 None
 1.45A 1q23K-5o9wA:
undetectable		 1q23K-5o9wA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		5 / 11 THR A 286
PHE A 211
LEU A 244
VAL A 276
PHE A  88
 None
 1.41A 1q23L-5o9wA:
undetectable		 1q23L-5o9wA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		5 / 12 LEU A  75
LEU A  78
ALA A  81
VAL A 278
LEU A 197
 EDO  A 403 (-3.7A)
None
None
None
None
 1.05A 1s9pA-5o9wA:
undetectable		 1s9pA-5o9wA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		5 / 12 LEU A  75
LEU A  78
ALA A  81
VAL A 278
LEU A 197
 EDO  A 403 (-3.7A)
None
None
None
None
 1.06A 1s9pD-5o9wA:
undetectable		 1s9pD-5o9wA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		6 / 12 HIS A 238
ASP A 240
LEU A 256
HIS A 295
SER A 307
PHE A 311
 NI  A 401 ( 3.3A)
NI  A 401 ( 2.5A)
AKG  A 402 (-3.6A)
NI  A 401 ( 3.3A)
AKG  A 402 (-2.5A)
AKG  A 402 (-4.8A)
 0.45A 1uobA-5o9wA:
22.8		 1uobA-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		5 / 11 HIS A 238
ASP A 240
THR A 245
ARG A 305
SER A 307
 NI  A 401 ( 3.3A)
NI  A 401 ( 2.5A)
None
AKG  A 402 (-2.7A)
AKG  A 402 (-2.5A)
 1.04A 1uofA-5o9wA:
21.4		 1uofA-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		5 / 11 HIS A 238
ASP A 240
THR A 245
HIS A 295
SER A 307
 NI  A 401 ( 3.3A)
NI  A 401 ( 2.5A)
None
NI  A 401 ( 3.3A)
AKG  A 402 (-2.5A)
 0.64A 1uofA-5o9wA:
21.4		 1uofA-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		3 / 3 LYS A 259
ASP A 280
CYH A 348
 None
 1.44A 2br4F-5o9wA:
undetectable		 2br4F-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		3 / 3 ARG A 305
ASP A 144
ASN A 221
 AKG  A 402 (-2.7A)
None
AKG  A 402 (-3.7A)
 0.86A 2zzmA-5o9wA:
undetectable		 2zzmA-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 6 ASP A 313
THR A 340
ILE A 320
PHE A 241
 None
None
EDO  A 411 ( 4.3A)
None
 1.10A 4acbC-5o9wA:
undetectable		 4acbC-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 7 GLY A 242
ASP A 240
GLY A 279
HIS A 295
 None
NI  A 401 ( 2.5A)
None
NI  A 401 ( 3.3A)
 0.94A 4c5nA-5o9wA:
undetectable		 4c5nA-5o9wA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		3 / 3 ASP A 144
GLU A 137
SER A 307
 None
None
AKG  A 402 (-2.5A)
 0.82A 5bw4B-5o9wA:
undetectable		 5bw4B-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 8 GLU A 283
GLY A 243
THR A 340
PHE A 335
 None
 0.97A 5flcB-5o9wA:
undetectable		 5flcB-5o9wA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 8 GLU A 283
GLY A 243
THR A 340
PHE A 335
 None
 0.96A 5flcF-5o9wA:
undetectable		 5flcF-5o9wA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 6 LEU A  63
CYH A  82
HIS A  79
LEU A  78
 None
None
EDO  A 403 (-4.0A)
None
 1.21A 5hpuC-5o9wA:
undetectable
5hpuD-5o9wA:
undetectable		 5hpuC-5o9wA:
undetectable
5hpuD-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		3 / 3 CYH A  82
LYS A  83
HIS A 291
 None
 1.21A 5js5A-5o9wA:
undetectable		 5js5A-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 5 ASP A 294
PRO A  43
ARG A 260
THR A 263
 None
 1.47A 5uxcA-5o9wA:
undetectable		 5uxcA-5o9wA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 6 VAL A 299
LEU A   9
MET A 115
PRO A  30
 None
 1.22A 6brdB-5o9wA:
undetectable		 6brdB-5o9wA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 5 GLN A  89
VAL A 276
PRO A 269
THR A 310
 None
 0.90A 6cduA-5o9wA:
undetectable
6cduB-5o9wA:
undetectable		 6cduA-5o9wA:
undetectable
6cduB-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 7 THR A 310
GLN A  89
VAL A 276
PRO A 269
 None
 0.97A 6cduA-5o9wA:
undetectable
6cduE-5o9wA:
undetectable		 6cduA-5o9wA:
undetectable
6cduE-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 6 GLN A  89
VAL A 276
PRO A 269
THR A 310
 None
 0.94A 6cduB-5o9wA:
1.4
6cduC-5o9wA:
1.4		 6cduB-5o9wA:
undetectable
6cduC-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 7 GLN A  89
VAL A 276
PRO A 269
THR A 310
 None
 0.88A 6cduC-5o9wA:
undetectable
6cduD-5o9wA:
undetectable		 6cduC-5o9wA:
undetectable
6cduD-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 7 GLN A  89
VAL A 276
PRO A 269
THR A 310
 None
 0.94A 6cduH-5o9wA:
undetectable
6cduI-5o9wA:
undetectable		 6cduH-5o9wA:
undetectable
6cduI-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5o9w THEBAINE
6-O-DEMETHYLASE
(Papaver
somniferum) 		4 / 5 GLN A  89
VAL A 276
PRO A 269
THR A 310
 None
 0.95A 6cduI-5o9wA:
undetectable
6cduJ-5o9wA:
undetectable		 6cduI-5o9wA:
undetectable
6cduJ-5o9wA:
undetectable