SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oa3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		3 / 3 TRP 0  99
ARG 0 164
THR 0  98
 None
 0.96A 1df7A-5oa30:
undetectable		 1df7A-5oa30:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		5 / 9 VAL 0  42
LEU 0  92
TYR 0  89
VAL 0  26
GLY 0  34
 None
 1.29A 1pxxB-5oa30:
undetectable		 1pxxB-5oa30:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		5 / 12 GLY 0 165
GLY 0 163
LEU 0 112
LEU 0 161
ALA 0 150
 None
C  1  75 ( 4.8A)
None
None
None
 1.15A 3kkzA-5oa30:
undetectable		 3kkzA-5oa30:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		5 / 11 TYR 0  64
LEU 0  72
ALA 0  24
ALA 0  29
THR 0  28
 None
 1.05A 3mdtB-5oa30:
undetectable		 3mdtB-5oa30:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 4 LEU 0 476
ILE 0 491
TYR 0 564
TYR 0 472
 None
 1.42A 3vt7A-5oa30:
undetectable		 3vt7A-5oa30:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 6 GLN 0 545
ARG 0 498
ASP 0 492
GLU 0 575
 None
 1.38A 4ax8A-5oa30:
2.1		 4ax8A-5oa30:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 6 GLN 0 545
ARG 0 498
ASP 0 492
GLU 0 575
 None
 1.37A 4azvA-5oa30:
2.1		 4azvA-5oa30:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 5 GLY 0  67
GLY 0  68
ASN 0 181
GLU 0  46
 None
 0.90A 4fglC-5oa30:
undetectable		 4fglC-5oa30:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 6 GLY 0  67
GLY 0  68
ASN 0 181
GLU 0  46
 None
 0.92A 4fglD-5oa30:
undetectable		 4fglD-5oa30:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 5 ILE 0 443
ARG 0 412
ASP 0 458
VAL 0 452
 None
 1.20A 4nkxC-5oa30:
undetectable		 4nkxC-5oa30:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D
(Homo
sapiens) 		4 / 5 ILE 0 443
ARG 0 412
ASP 0 458
VAL 0 452
 None
 1.20A 4nkxD-5oa30:
undetectable		 4nkxD-5oa30:
20.96