SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oaf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 ALA A  82
GLN A  85
PHE A  93
LEU A  87
VAL A  66
 None
 1.05A 1xdkE-5oafA:
undetectable		 1xdkE-5oafA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		5 / 12 ALA A  82
GLN A  85
PHE A  93
LEU A  87
VAL A  66
 None
 1.00A 1xiuA-5oafA:
undetectable		 1xiuA-5oafA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		4 / 4 LEU A 410
THR A 411
ILE A 377
HIS A  20
 None
None
None
ADP  A 501 (-3.7A)
 1.40A 2jfaB-5oafA:
undetectable		 2jfaB-5oafA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		5 / 9 LEU A 315
ALA A 324
LEU A 319
ALA A  65
PHE A 329
 None
 1.26A 2vcvH-5oafA:
undetectable		 2vcvH-5oafA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		5 / 11 GLY A  23
ALA A  78
LEU A  79
ILE A 350
LEU A 354
 None
ADP  A 501 (-3.6A)
None
None
None
 1.03A 4kt0A-5oafA:
undetectable
4kt0J-5oafA:
undetectable		 4kt0A-5oafA:
7.79
4kt0J-5oafA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		5 / 11 LEU A  87
VAL A 298
ILE A 328
ALA A  48
ILE A 361
 None
 1.15A 5d75A-5oafA:
undetectable		 5d75A-5oafA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		4 / 6 ARG A 118
GLU A 114
GLU A 100
VAL A 101
 None
 1.36A 5h4dA-5oafA:
undetectable		 5h4dA-5oafA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5oaf RUVB-LIKE 1
(Homo
sapiens) 		4 / 7 LEU A 355
GLY A 349
LEU A 307
GLY A  98
 None
 0.65A 6eu9D-5oafA:
undetectable		 6eu9D-5oafA:
26.37