SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 GLN A  61
HIS A 467
PRO A 704
 None
GOL  A 804 (-3.6A)
GOL  A 804 (-4.6A)
 0.09A 1d8cA-5oasA:
52.9		 1d8cA-5oasA:
58.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 637
THR A 585
VAL A 650
LEU A 641
LEU A 581
 None
 1.15A 1kqwA-5oasA:
undetectable		 1kqwA-5oasA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 459
VAL A 656
ILE A 603
ARG A 647
 EDO  A 808 (-3.8A)
None
None
None
 0.97A 1opjB-5oasA:
undetectable		 1opjB-5oasA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 366
PHE A 411
GLY A 362
THR A 369
VAL A 414
 None
 1.25A 1pwyE-5oasA:
undetectable		 1pwyE-5oasA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 595
TRP A 645
LYS A 511
 None
 1.06A 1qu2A-5oasA:
undetectable		 1qu2A-5oasA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 393
MET A 296
ILE A 374
LEU A 420
PRO A 421
 None
None
EDO  A 812 ( 4.2A)
EDO  A 807 (-4.9A)
None
 0.95A 1rx8A-5oasA:
undetectable		 1rx8A-5oasA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 366
PHE A 411
GLY A 362
THR A 369
VAL A 414
 None
 1.24A 1v3qE-5oasA:
undetectable		 1v3qE-5oasA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 632
SER A 676
TYR A 677
 None
 0.79A 1x70A-5oasA:
2.5		 1x70A-5oasA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 551
HIS A 554
LYS A 555
 GOL  A 802 ( 3.6A)
None
GOL  A 802 (-3.1A)
 1.09A 1y7iA-5oasA:
undetectable		 1y7iA-5oasA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 THR A 253
PRO A 249
TYR A 160
 None
 0.93A 2dxrA-5oasA:
undetectable		 2dxrA-5oasA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 577
THR A 578
ILE A  64
HIS A  68
 None
 1.20A 2jfaB-5oasA:
undetectable		 2jfaB-5oasA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 SER A 370
GLU A 415
PHE A 411
VAL A 452
ALA A 507
 None
 1.34A 2kceA-5oasA:
undetectable		 2kceA-5oasA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 128
ASN A 132
MET A 271
VAL A 121
LEU A 295
 None
 1.22A 2q7kA-5oasA:
undetectable		 2q7kA-5oasA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 316
ARG A 319
ASP A 260
 None
 0.98A 2qe6A-5oasA:
undetectable		 2qe6A-5oasA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 316
ARG A 319
ASP A 260
 None
 0.94A 2qe6B-5oasA:
1.8		 2qe6B-5oasA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 549
GLN A 508
ALA A 266
THR A 269
 None
 1.08A 2xfhA-5oasA:
undetectable		 2xfhA-5oasA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 681
TYR A 677
VAL A 608
ASP A 612
ASN A 687
 None
 1.47A 3a65A-5oasA:
undetectable		 3a65A-5oasA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 9 PHE A  98
VAL A 497
LEU A 440
ALA A 442
ALA A  95
 None
 1.48A 3ax7B-5oasA:
undetectable		 3ax7B-5oasA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 7 THR A  34
PHE A  35
LEU A 371
LEU A 418
 None
 0.90A 3bgdB-5oasA:
undetectable		 3bgdB-5oasA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 473
ALA A 472
ILE A  64
ILE A 466
THR A 578
 None
 0.95A 3el9B-5oasA:
undetectable		 3el9B-5oasA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 340
GLU A 361
ASP A 281
 MG  A 820 (-3.8A)
None
EDO  A 814 (-3.6A)
 0.92A 3g2oA-5oasA:
undetectable		 3g2oA-5oasA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.31A 3k39A-5oasA:
undetectable		 3k39A-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.30A 3k39B-5oasA:
undetectable		 3k39B-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.32A 3k39C-5oasA:
undetectable		 3k39C-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.33A 3k39E-5oasA:
undetectable		 3k39E-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.32A 3k39F-5oasA:
undetectable		 3k39F-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.32A 3k39G-5oasA:
undetectable		 3k39G-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.31A 3k39H-5oasA:
undetectable		 3k39H-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.31A 3k39I-5oasA:
undetectable		 3k39I-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.34A 3k39J-5oasA:
undetectable		 3k39J-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.31A 3k39K-5oasA:
undetectable		 3k39K-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 422
GLU A 415
LEU A 425
ARG A 450
ALA A  41
 None
 1.30A 3k39O-5oasA:
undetectable		 3k39O-5oasA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 114
VAL A 556
PRO A 531
GLY A 237
ALA A 266
 None
 0.92A 3ku1H-5oasA:
undetectable		 3ku1H-5oasA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 460
ASP A 275
PRO A 396
GLU A 432
 EDO  A 808 ( 3.8A)
MG  A 820 ( 4.1A)
MG  A 820 (-4.7A)
MG  A 820 ( 2.7A)
 1.40A 3l2uA-5oasA:
0.8		 3l2uA-5oasA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 460
ASP A 275
PRO A 396
GLU A 432
 EDO  A 808 ( 3.8A)
MG  A 820 ( 4.1A)
MG  A 820 (-4.7A)
MG  A 820 ( 2.7A)
 1.39A 3l2wA-5oasA:
0.8		 3l2wA-5oasA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 497
ALA A  95
THR A 437
THR A 436
PRO A 401
 None
 1.08A 3mdzA-5oasA:
undetectable		 3mdzA-5oasA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 365
ASP A 283
ASN A 348
GLU A 361
 None
 1.40A 3vywD-5oasA:
undetectable		 3vywD-5oasA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 636
LYS A 397
ARG A 632
 None
MG  A 820 (-3.3A)
None
 1.12A 3w1wA-5oasA:
undetectable
3w1wB-5oasA:
undetectable		 3w1wA-5oasA:
18.83
3w1wB-5oasA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 632
ARG A 636
LYS A 397
 None
None
MG  A 820 (-3.3A)
 1.15A 3w1wA-5oasA:
undetectable
3w1wB-5oasA:
undetectable		 3w1wA-5oasA:
18.83
3w1wB-5oasA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 341
GLY A 343
THR A 407
LEU A 410
SER A 370
 None
 1.21A 4or0A-5oasA:
undetectable		 4or0A-5oasA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 404
THR A 407
ALA A 405
ILE A 454
GLY A 428
 None
 1.13A 4qvqK-5oasA:
undetectable
4qvqL-5oasA:
undetectable		 4qvqK-5oasA:
14.72
4qvqL-5oasA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 404
THR A 407
ALA A 405
ILE A 454
GLY A 428
 None
 1.13A 4qvqY-5oasA:
undetectable
4qvqZ-5oasA:
undetectable		 4qvqY-5oasA:
14.72
4qvqZ-5oasA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 6 SER A 638
GLY A 605
GLU A 630
ASP A 668
 None
 1.06A 4uckB-5oasA:
undetectable		 4uckB-5oasA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 553
VAL A 558
ILE A 509
HIS A 549
 None
 1.12A 4xo7B-5oasA:
7.9		 4xo7B-5oasA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 138
LEU A 551
LEU A 524
THR A 145
LEU A 142
 None
GOL  A 802 ( 3.6A)
GOL  A 802 ( 4.4A)
None
None
 1.00A 4z91A-5oasA:
1.0
4z91B-5oasA:
1.0
4z91C-5oasA:
1.1
4z91D-5oasA:
1.1
4z91E-5oasA:
1.1		 4z91A-5oasA:
18.19
4z91B-5oasA:
18.19
4z91C-5oasA:
18.19
4z91D-5oasA:
18.19
4z91E-5oasA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 142
LEU A 138
LEU A 551
LEU A 524
THR A 145
 None
None
GOL  A 802 ( 3.6A)
GOL  A 802 ( 4.4A)
None
 1.01A 4z91A-5oasA:
1.0
4z91B-5oasA:
1.0
4z91C-5oasA:
1.1
4z91D-5oasA:
1.1
4z91E-5oasA:
1.1		 4z91A-5oasA:
18.19
4z91B-5oasA:
18.19
4z91C-5oasA:
18.19
4z91D-5oasA:
18.19
4z91E-5oasA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 10 THR A 145
LEU A 142
LEU A 138
LEU A 551
LEU A 524
 None
None
None
GOL  A 802 ( 3.6A)
GOL  A 802 ( 4.4A)
 1.04A 4z91A-5oasA:
1.0
4z91B-5oasA:
1.0
4z91C-5oasA:
1.1
4z91D-5oasA:
1.1
4z91E-5oasA:
1.1		 4z91A-5oasA:
18.19
4z91B-5oasA:
18.19
4z91C-5oasA:
18.19
4z91D-5oasA:
18.19
4z91E-5oasA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 264
HIS A 239
ASP A 107
 None
 0.77A 5c0oG-5oasA:
undetectable		 5c0oG-5oasA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 538
THR A 537
VAL A 558
HIS A 530
 None
 1.21A 5ecnA-5oasA:
undetectable		 5ecnA-5oasA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  58
TYR A 707
GLU A 709
GLU A 432
GLU A 403
 GOL  A 804 ( 4.6A)
None
None
MG  A 820 ( 2.7A)
None
 1.44A 5iqeD-5oasA:
undetectable		 5iqeD-5oasA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  92
GLU A  96
ILE A 429
LYS A 445
 None
 1.05A 5jh7C-5oasA:
undetectable		 5jh7C-5oasA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 453
ILE A 454
ALA A 446
ILE A 444
CYH A 443
 None
 1.33A 5mlmA-5oasA:
2.1		 5mlmA-5oasA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 527
HIS A 549
HIS A 530
 None
 1.14A 5oexA-5oasA:
undetectable		 5oexA-5oasA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 527
HIS A 549
HIS A 530
 None
 1.12A 5oexB-5oasA:
undetectable		 5oexB-5oasA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 527
HIS A 549
HIS A 530
 None
 1.14A 5oexC-5oasA:
undetectable		 5oexC-5oasA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 527
HIS A 549
HIS A 530
 None
 1.18A 5oexD-5oasA:
undetectable		 5oexD-5oasA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 THR A 468
MET A 470
HIS A  68
 None
 0.86A 5uunA-5oasA:
1.9		 5uunA-5oasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 557
GLN A 562
ASN A 536
LEU A 499
 None
 1.21A 6ekuA-5oasA:
undetectable		 6ekuA-5oasA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 THR A   2
ALA A 282
LYS A 285
 None
 0.78A 6fgcA-5oasA:
undetectable		 6fgcA-5oasA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		3 / 3 THR A   2
ALA A 282
LYS A 285
 None
 0.72A 6fgdA-5oasA:
undetectable		 6fgdA-5oasA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 270
GLN A 116
VAL A 394
TRP A 292
 None
 0.91A 6j20A-5oasA:
undetectable		 6j20A-5oasA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 8 LYS A 445
GLY A 502
LEU A 503
ALA A 507
 None
 0.70A 6mdqA-5oasA:
undetectable		 6mdqA-5oasA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5oas MALATE SYNTHASE G
(Pseudomonas
aeruginosa) 		4 / 8 TRP A 610
HIS A 713
ARG A 636
GLU A 432
 None
GOL  A 801 (-3.6A)
None
MG  A 820 ( 2.7A)
 1.09A 6mn4C-5oasA:
undetectable		 6mn4C-5oasA:
16.25