SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 6 ARG A 216
GLY A 383
ASP A 381
TYR A 406
 None
 1.21A 1kf6M-5oatA:
undetectable
1kf6N-5oatA:
undetectable		 1kf6M-5oatA:
19.64
1kf6N-5oatA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 6 ILE A 168
VAL A 176
VAL A 219
ILE A 250
 None
 0.72A 1uwhA-5oatA:
20.8		 1uwhA-5oatA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 6 ILE A 168
VAL A 219
ILE A 250
ILE A 333
 None
 0.78A 1uwhA-5oatA:
20.8		 1uwhA-5oatA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		5 / 12 LEU A 559
TRP A 490
LEU A 482
ILE A 543
LEU A 507
 None
 1.12A 2jfaA-5oatA:
undetectable		 2jfaA-5oatA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 6 PHE A 546
GLN A 320
ASN A 249
LEU A 305
 None
 1.29A 2nyrA-5oatA:
undetectable		 2nyrA-5oatA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		5 / 12 LEU A 301
GLY A 415
LEU A 463
ILE A 455
LEU A 317
 None
 1.02A 3ijdA-5oatA:
undetectable		 3ijdA-5oatA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		5 / 12 LEU A 301
GLY A 415
LEU A 463
ILE A 455
LEU A 317
 None
 1.06A 3ijdB-5oatA:
undetectable		 3ijdB-5oatA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 7 VAL A 325
LEU A 343
ASN A 342
ILE A 417
 None
 0.97A 3rfmA-5oatA:
undetectable		 3rfmA-5oatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 5 LYS A 196
VAL A 251
LEU A 344
ASP A 359
 None
None
None
MG  A 601 (-3.1A)
 0.81A 3wzdA-5oatA:
19.4		 3wzdA-5oatA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 4 LEU A 301
SER A 303
LEU A 344
LEU A 317
 None
 1.11A 4n09A-5oatA:
undetectable		 4n09A-5oatA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 8 LEU A 292
PRO A 220
ARG A 222
SER A 358
 None
 1.04A 4qknA-5oatA:
undetectable		 4qknA-5oatA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 8 ALA A 194
MET A 294
LEU A 344
SER A 358
 None
 0.70A 4wboB-5oatA:
undetectable		 4wboB-5oatA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		5 / 12 MET A 288
LEU A 260
ALA A 273
HIS A 228
LEU A 159
 None
 1.12A 4zn7A-5oatA:
undetectable		 4zn7A-5oatA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		3 / 3 PRO A 473
LEU A 338
SER A 407
 None
 0.75A 5fsaB-5oatA:
undetectable		 5fsaB-5oatA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 6 LEU A 237
ILE A 253
THR A 218
MET A 198
 None
 1.41A 5ljeA-5oatA:
undetectable		 5ljeA-5oatA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		4 / 8 ILE A 253
LEU A 292
MET A 198
LEU A 290
 None
 0.94A 5u4sB-5oatA:
undetectable		 5u4sB-5oatA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		3 / 3 LYS A 196
LEU A 344
ASP A 359
 None
None
MG  A 601 (-3.1A)
 0.80A 5zv2A-5oatA:
18.6		 5zv2A-5oatA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN
(Tribolium
castaneum) 		5 / 12 LEU A 447
ILE A 421
TYR A 419
LEU A 321
LEU A 463
 None
 1.20A 6ie8A-5oatA:
undetectable		 6ie8A-5oatA:
18.40