SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5obt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 LEU A 183
SER A 175
ASN A  72
 None
SNN  A 176 ( 3.2A)
None
 0.80A 1bx4A-5obtA:
3.1		 1bx4A-5obtA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 7 LEU A  85
MET E 328
LEU E 324
GLU E 287
 None
 1.05A 1linA-5obtA:
undetectable		 1linA-5obtA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 PHE A 225
LEU A 191
LEU A 183
SER A 241
PHE A 214
 None
 1.11A 1xdkB-5obtA:
undetectable		 1xdkB-5obtA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 11 LEU A 196
ILE A 224
MET A 185
LEU A  85
MET A 276
 None
 1.35A 2n27A-5obtA:
undetectable		 2n27A-5obtA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 6 TYR A 263
TYR A  70
GLN A  76
ILE A 104
 None
 1.46A 2pgzD-5obtA:
undetectable
2pgzE-5obtA:
undetectable		 2pgzD-5obtA:
16.00
2pgzE-5obtA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		3 / 3 ASP A 141
PHE A 144
LEU A 148
 None
 0.38A 2zi9A-5obtA:
undetectable		 2zi9A-5obtA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 GLN A  55
GLY E 329
LEU E 326
LEU A  91
ASN A  95
 None
 1.17A 2zw9B-5obtA:
2.5		 2zw9B-5obtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 LEU A 270
ASP A 269
GLY A 268
TYR A 251
HIS A  81
 None
 1.23A 3hgiA-5obtA:
undetectable		 3hgiA-5obtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 222
GLY A 178
LEU A 191
SER A  67
ALA A 218
 None
None
None
SNN  A 176 ( 4.0A)
SNN  A 176 ( 3.7A)
 1.08A 3kkzB-5obtA:
2.7		 3kkzB-5obtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 6 PHE A 214
LEU A 143
ALA A 193
LEU A 200
 None
 0.94A 3t3zD-5obtA:
undetectable		 3t3zD-5obtA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 5 LEU A  85
PHE A 171
LEU A  91
TRP A 275
 None
 1.34A 5m10A-5obtA:
1.7		 5m10A-5obtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 6 GLY A 181
ASP A 195
GLY A 178
GLY A 184
 None
None
None
SNN  A 176 ( 3.3A)
 0.74A 6ag0C-5obtA:
undetectable		 6ag0C-5obtA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME
(Arabidopsis
thaliana) 		4 / 4 VAL A 154
GLY A 157
ASP A 137
ASP A 132
 None
 1.47A 6cjkC-5obtA:
undetectable		 6cjkC-5obtA:
undetectable