SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oce'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A 235
ALA A 133
VAL A 104
TYR A 251
 None
PLM  A 401 (-2.8A)
PLM  A 401 ( 4.7A)
None
 0.81A 1epbB-5oceA:
undetectable		 1epbB-5oceA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 189
LEU A 122
LEU A 197
LEU A 234
 None
PLM  A 401 ( 4.1A)
None
None
 1.01A 2ab2A-5oceA:
undetectable		 2ab2A-5oceA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 230
TYR A 141
ASN A 192
LEU A 110
 None
None
None
PLM  A 401 ( 4.4A)
 1.18A 2hzqA-5oceA:
undetectable		 2hzqA-5oceA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 182
PRO A 220
VAL A 208
ALA A 186
LEU A 234
 None
 1.15A 2x2nC-5oceA:
undetectable		 2x2nC-5oceA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PRO A 220
PHE A 272
ALA A 123
 None
 0.61A 3itaD-5oceA:
undetectable		 3itaD-5oceA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 156
TYR A 157
ARG A 159
LEU A 151
 None
 1.12A 3rd0A-5oceA:
undetectable		 3rd0A-5oceA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 TRP A 283
VAL A 210
PHE A 212
ILE A 276
 None
 0.82A 3zjqA-5oceA:
undetectable		 3zjqA-5oceA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 TRP A 283
VAL A 210
PHE A 212
ILE A 276
 None
 0.83A 3zjqB-5oceA:
undetectable		 3zjqB-5oceA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 199
PHE A 213
ILE A 276
ASN A 275
PHE A 212
 None
 1.29A 4c49A-5oceA:
undetectable		 4c49A-5oceA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 THR A 256
GLY A 259
ILE A 264
VAL A 261
 None
 0.96A 4e1vE-5oceA:
undetectable		 4e1vE-5oceA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 THR A 256
GLY A 259
ILE A 264
VAL A 261
 None
 0.98A 4e1vG-5oceA:
undetectable		 4e1vG-5oceA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLN A 266
THR A 265
THR A 262
 None
 0.81A 4fufA-5oceA:
undetectable		 4fufA-5oceA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 185
LEU A 234
LEU A 254
ALA A 269
PHE A 272
 None
 1.29A 4rtbA-5oceA:
undetectable		 4rtbA-5oceA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 189
THR A 230
GLY A 231
ARG A 118
 None
 1.17A 6gtqB-5oceA:
undetectable
6gtqD-5oceA:
undetectable		 6gtqB-5oceA:
undetectable
6gtqD-5oceA:
undetectable