SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ocm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 12 GLU A 284
GLN A 285
GLY A 273
GLY A 275
ALA A 269
 None
 1.18A 1httC-5ocmA:
3.3		 1httC-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 12 GLU A 284
GLN A 285
GLY A 273
GLY A 275
ALA A 269
 None
 1.25A 1httD-5ocmA:
3.2		 1httD-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 12 GLY A 276
GLY A 275
VAL A 239
LEU A 270
MET A 282
 None
 1.04A 1ya4B-5ocmA:
undetectable		 1ya4B-5ocmA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 10 ILE A 209
ALA A 205
ASN A 182
ALA A 202
ILE A 176
 None
 1.17A 2aclC-5ocmA:
undetectable		 2aclC-5ocmA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 12 ASP A 162
GLY A 117
LEU A  92
ASP A 170
LEU A 168
 None
 1.35A 2nv4A-5ocmA:
undetectable		 2nv4A-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		4 / 5 LEU A  42
VAL A  88
LEU A 115
MET A  14
 None
None
None
NAP  A 301 (-4.9A)
 1.04A 2oiqA-5ocmA:
undetectable		 2oiqA-5ocmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		4 / 8 ILE A 209
LEU A 181
LEU A 185
PHE A 201
 None
 0.90A 2vctC-5ocmA:
undetectable		 2vctC-5ocmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 12 GLY A 153
ALA A  21
PHE A 132
ASP A 130
THR A 157
 None
 1.12A 2vdvE-5ocmA:
5.8		 2vdvE-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 11 GLY A 153
ALA A  21
PHE A 132
ASP A 130
THR A 157
 None
 1.12A 2vdvF-5ocmA:
5.8		 2vdvF-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 11 LEU A   9
ALA A  50
ALA A  56
VAL A  65
LEU A  84
 None
 1.24A 3bszE-5ocmA:
undetectable		 3bszE-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		4 / 5 THR A  93
THR A   7
LEU A  80
LEU A  77
 NAP  A 301 ( 4.3A)
None
None
None
 0.82A 4lvcB-5ocmA:
4.9		 4lvcB-5ocmA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 12 VAL A  76
TYR A 114
LEU A  89
THR A  93
THR A 103
 NAP  A 301 (-4.9A)
None
None
NAP  A 301 ( 4.3A)
None
 1.29A 4o5fA-5ocmA:
undetectable
4o5fB-5ocmA:
undetectable		 4o5fA-5ocmA:
undetectable
4o5fB-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 12 GLU A 284
GLN A 285
GLY A 273
GLY A 275
ALA A 269
 None
 1.25A 5e3iA-5ocmA:
2.8		 5e3iA-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		5 / 11 GLU A 284
GLN A 285
GLY A 273
GLY A 275
ALA A 269
 None
 1.25A 5e3iB-5ocmA:
2.6		 5e3iB-5ocmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Streptosporangiu
m
roseum) 		3 / 3 SER A 136
TYR A 135
TYR A 158
 None
 0.90A 5lakA-5ocmA:
undetectable
5lakI-5ocmA:
undetectable		 5lakA-5ocmA:
undetectable
5lakI-5ocmA:
undetectable