SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ocs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		5 / 12 ILE A 172
ALA A 164
ARG A 219
ASN A  12
LEU A  13
 None
 1.43A 1u70A-5ocsA:
undetectable		 1u70A-5ocsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 7 CYH A  25
TYR A  27
HIS A  38
TRP A 114
 FMN  A 401 (-3.1A)
None
None
None
 1.29A 1yvmA-5ocsA:
undetectable		 1yvmA-5ocsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 8 LEU A  71
VAL A  89
GLY A  43
MET A  45
 None
 1.02A 2po5A-5ocsA:
undetectable		 2po5A-5ocsA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		5 / 12 VAL A  89
LEU A  13
GLU A 173
ALA A  50
SER A  48
 None
 0.94A 3apvA-5ocsA:
undetectable		 3apvA-5ocsA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 6 VAL A 161
LYS A 165
GLY A 171
LEU A  86
 None
 0.94A 3bjwE-5ocsA:
undetectable		 3bjwE-5ocsA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 6 ALA A  20
ILE A  54
HIS A 263
VAL A 300
 None
None
None
FMN  A 401 (-4.5A)
 0.86A 3nneG-5ocsA:
undetectable		 3nneG-5ocsA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		5 / 9 ALA A  22
PRO A  23
ILE A  54
ARG A 231
SER A 322
 FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
None
FMN  A 401 (-2.8A)
None
 0.43A 4a3uA-5ocsA:
38.2		 4a3uA-5ocsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 7 PRO A  23
ILE A  54
ARG A 231
SER A 322
 FMN  A 401 (-4.1A)
None
FMN  A 401 (-2.8A)
None
 0.41A 4a3uB-5ocsA:
38.4		 4a3uB-5ocsA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 6 ILE A  19
ASN A  17
GLU A 173
VAL A  89
 None
 1.04A 4ejwB-5ocsA:
undetectable		 4ejwB-5ocsA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 8 GLU A 253
GLU A 205
ARG A 207
GLY A 246
 None
 0.91A 4fgzA-5ocsA:
undetectable
4fgzB-5ocsA:
undetectable		 4fgzA-5ocsA:
22.16
4fgzB-5ocsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 6 PRO A  23
ARG A 231
GLY A 179
ALA A  57
 FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
None
FMN  A 401 (-3.3A)
 1.03A 4g0uA-5ocsA:
undetectable		 4g0uA-5ocsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		4 / 5 ARG A 231
TRP A 229
ILE A  10
ASN A  17
 FMN  A 401 (-2.8A)
None
None
None
 1.47A 4i00A-5ocsA:
undetectable		 4i00A-5ocsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		3 / 3 ARG A  18
PRO A   2
ASN A 316
 None
 0.97A 5jwaA-5ocsA:
undetectable
5jwaH-5ocsA:
undetectable		 5jwaA-5ocsA:
19.56
5jwaH-5ocsA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		5 / 9 ALA A  59
THR A  58
ALA A  57
ALA A 102
GLY A  32
 None
None
FMN  A 401 (-3.3A)
None
None
 1.09A 5l5zK-5ocsA:
undetectable
5l5zL-5ocsA:
undetectable		 5l5zK-5ocsA:
19.63
5l5zL-5ocsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		5 / 9 ALA A  59
THR A  58
ALA A  57
ALA A 102
GLY A  32
 None
None
FMN  A 401 (-3.3A)
None
None
 1.09A 5l5zY-5ocsA:
undetectable
5l5zZ-5ocsA:
undetectable		 5l5zY-5ocsA:
19.63
5l5zZ-5ocsA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		5 / 5 CYH A  25
ILE A  66
HIS A 178
HIS A 181
TYR A 183
 FMN  A 401 (-3.1A)
None
FMN  A 401 ( 3.7A)
ACT  A 402 ( 3.8A)
ACT  A 402 (-4.6A)
 0.00A 5ocsA-5ocsA:
70.3		 5ocsA-5ocsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE
(Cupriavidus
metallidurans) 		5 / 5 CYH A  25
ILE A  66
HIS A 178
HIS A 181
TYR A 183
 FMN  A 401 (-3.1A)
None
FMN  A 401 ( 3.7A)
ACT  A 402 ( 3.8A)
ACT  A 402 (-4.6A)
 0.03A 5ocsC-5ocsA:
68.9		 5ocsC-5ocsA:
100.00