SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ocy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN
(Homo
sapiens) 		4 / 4 THR H 124
PRO H 154
THR H 123
PRO H 125
 None
 1.34A 1dsdC-5ocyH:
undetectable		 1dsdC-5ocyH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN
(Homo
sapiens) 		4 / 4 THR H 124
PRO H 154
THR H 123
PRO H 125
 None
 1.34A 1dsdC-5ocyH:
undetectable		 1dsdC-5ocyH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN
ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 4 LEU L  47
VAL L  48
ILE L  49
TRP H 106
 None
 1.04A 1s9qB-5ocyL:
undetectable		 1s9qB-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.92A 1zzrA-5ocyL:
undetectable
1zzrB-5ocyL:
undetectable		 1zzrA-5ocyL:
16.84
1zzrB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.92A 1zzrA-5ocyL:
undetectable
1zzrB-5ocyL:
undetectable		 1zzrA-5ocyL:
16.84
1zzrB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.93A 1zzuA-5ocyL:
undetectable
1zzuB-5ocyL:
undetectable		 1zzuA-5ocyL:
16.84
1zzuB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.93A 1zzuA-5ocyL:
undetectable
1zzuB-5ocyL:
undetectable		 1zzuA-5ocyL:
16.84
1zzuB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		5 / 11 GLY L  82
GLN L  80
ILE L  76
GLN L  38
PHE L  63
 None
 1.50A 2dr2A-5ocyL:
undetectable		 2dr2A-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN
(Homo
sapiens) 		4 / 5 LEU H  81
ILE H  99
TRP H 110
TYR H  60
 None
 1.32A 2zlcA-5ocyH:
undetectable		 2zlcA-5ocyH:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 ASP L 214
SER L 211
SER L 196
GLU L 207
 None
 1.34A 3bc9A-5ocyL:
6.3		 3bc9A-5ocyL:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.92A 3dqrA-5ocyL:
undetectable
3dqrB-5ocyL:
undetectable		 3dqrA-5ocyL:
16.84
3dqrB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.96A 3dqrA-5ocyL:
undetectable
3dqrB-5ocyL:
undetectable		 3dqrA-5ocyL:
16.84
3dqrB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		5 / 11 GLN L  39
VAL L  40
PRO L  41
ILE L  59
ILE L  76
 None
 1.48A 3ganA-5ocyL:
undetectable		 3ganA-5ocyL:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.91A 3jx2A-5ocyL:
undetectable
3jx2B-5ocyL:
undetectable		 3jx2A-5ocyL:
16.84
3jx2B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.91A 3jx2A-5ocyL:
undetectable
3jx2B-5ocyL:
undetectable		 3jx2A-5ocyL:
16.84
3jx2B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.96A 3jx3A-5ocyL:
undetectable
3jx3B-5ocyL:
undetectable		 3jx3A-5ocyL:
16.84
3jx3B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.91A 3jx3A-5ocyL:
undetectable
3jx3B-5ocyL:
undetectable		 3jx3A-5ocyL:
16.84
3jx3B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.92A 3jx4A-5ocyL:
undetectable
3jx4B-5ocyL:
undetectable		 3jx4A-5ocyL:
16.84
3jx4B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.92A 3jx5A-5ocyL:
undetectable
3jx5B-5ocyL:
undetectable		 3jx5A-5ocyL:
16.84
3jx5B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.92A 3jx5A-5ocyL:
undetectable
3jx5B-5ocyL:
undetectable		 3jx5A-5ocyL:
16.84
3jx5B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.88A 3jx6A-5ocyL:
undetectable
3jx6B-5ocyL:
undetectable		 3jx6A-5ocyL:
16.84
3jx6B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.89A 3jx6A-5ocyL:
undetectable
3jx6B-5ocyL:
undetectable		 3jx6A-5ocyL:
16.84
3jx6B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN
ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		5 / 12 PHE H 173
VAL L 199
VAL L 148
PRO L 117
PHE L 143
 None
 1.39A 3nbrA-5ocyH:
undetectable		 3nbrA-5ocyH:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.87A 3nljA-5ocyL:
undetectable
3nljB-5ocyL:
undetectable		 3nljA-5ocyL:
16.84
3nljB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.88A 3nljA-5ocyL:
undetectable
3nljB-5ocyL:
undetectable		 3nljA-5ocyL:
16.84
3nljB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.89A 3nlpA-5ocyL:
undetectable
3nlpB-5ocyL:
undetectable		 3nlpA-5ocyL:
16.84
3nlpB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.91A 3nlpA-5ocyL:
undetectable
3nlpB-5ocyL:
undetectable		 3nlpA-5ocyL:
16.84
3nlpB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 8 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.87A 3nlqA-5ocyL:
undetectable
3nlqB-5ocyL:
undetectable		 3nlqA-5ocyL:
16.84
3nlqB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.89A 3nlqA-5ocyL:
undetectable
3nlqB-5ocyL:
undetectable		 3nlqA-5ocyL:
16.84
3nlqB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.89A 3nlrA-5ocyL:
undetectable
3nlrB-5ocyL:
undetectable		 3nlrA-5ocyL:
16.84
3nlrB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 8 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.88A 3nlrA-5ocyL:
undetectable
3nlrB-5ocyL:
undetectable		 3nlrA-5ocyL:
16.84
3nlrB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.94A 4cx3A-5ocyL:
undetectable
4cx3B-5ocyL:
undetectable		 4cx3A-5ocyL:
16.84
4cx3B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.91A 4cx3A-5ocyL:
undetectable
4cx3B-5ocyL:
undetectable		 4cx3A-5ocyL:
16.84
4cx3B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.94A 4cx4A-5ocyL:
undetectable
4cx4B-5ocyL:
undetectable		 4cx4A-5ocyL:
16.84
4cx4B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.91A 4cx4A-5ocyL:
undetectable
4cx4B-5ocyL:
undetectable		 4cx4A-5ocyL:
16.84
4cx4B-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.86A 5addA-5ocyL:
undetectable
5addB-5ocyL:
undetectable		 5addA-5ocyL:
16.84
5addB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.84A 5adeA-5ocyL:
undetectable
5adeB-5ocyL:
undetectable		 5adeA-5ocyL:
16.84
5adeB-5ocyL:
16.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 8 SER L  35
TRP L  92
SER L  97
PHE L 101
 None
 0.59A 5alcL-5ocyL:
18.6		 5alcL-5ocyL:
72.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5ocy ACPA E4 FAB FRAGMENT
- HEAVY CHAIN
ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 6 ALA L  44
SER L  43
ASP H 108
PRO H 109
 None
 1.20A 5c6pA-5ocyL:
undetectable		 5c6pA-5ocyL:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 6 GLY L 156
THR L 157
SER L 194
HIS L 192
 None
 0.99A 5ewuA-5ocyL:
undetectable		 5ewuA-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 6 GLY L 156
THR L 157
SER L 194
HIS L 192
 None
 0.86A 5ewuB-5ocyL:
undetectable		 5ewuB-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL L 109
ARG L  62
VAL L  18
GLU L  84
 None
 0.92A 5g0pA-5ocyL:
undetectable
5g0pB-5ocyL:
undetectable		 5g0pA-5ocyL:
16.84
5g0pB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 7 GLU L  84
VAL L 109
ARG L  62
VAL L  18
 None
 0.94A 5g0pA-5ocyL:
undetectable
5g0pB-5ocyL:
undetectable		 5g0pA-5ocyL:
16.84
5g0pB-5ocyL:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR L  73
SER L  66
THR L  71
SER L  68
 None
 1.02A 5l4eA-5ocyL:
undetectable
5l4eB-5ocyL:
undetectable
5l4eC-5ocyL:
undetectable
5l4eD-5ocyL:
undetectable
5l4eE-5ocyL:
undetectable		 5l4eA-5ocyL:
13.38
5l4eB-5ocyL:
13.38
5l4eC-5ocyL:
13.38
5l4eD-5ocyL:
13.38
5l4eE-5ocyL:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR L  19
SER L  64
ALA L  72
ASP L  52
 None
 1.08A 5l5fY-5ocyL:
undetectable
5l5fZ-5ocyL:
undetectable		 5l5fY-5ocyL:
15.82
5l5fZ-5ocyL:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		5 / 9 THR L  19
THR L  73
SER L  66
THR L  71
SER L  68
 None
 1.30A 5muoA-5ocyL:
undetectable
5muoB-5ocyL:
undetectable
5muoC-5ocyL:
undetectable
5muoD-5ocyL:
undetectable
5muoE-5ocyL:
undetectable		 5muoA-5ocyL:
27.96
5muoB-5ocyL:
27.96
5muoC-5ocyL:
27.96
5muoD-5ocyL:
27.96
5muoE-5ocyL:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		5 / 9 VAL L  10
LEU L 107
GLY L  78
LEU L  79
GLN L  16
 None
 1.35A 6czmA-5ocyL:
undetectable
6czmB-5ocyL:
undetectable		 6czmA-5ocyL:
undetectable
6czmB-5ocyL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens) 		5 / 10 VAL L  10
LEU L 107
GLY L  78
LEU L  79
GLN L  16
 None
 1.32A 6czmE-5ocyL:
undetectable
6czmF-5ocyL:
undetectable		 6czmE-5ocyL:
undetectable
6czmF-5ocyL:
undetectable