SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5odb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		5 / 9 VAL B  96
LEU B  46
TRP A 114
VAL A  99
GLY A 110
 None
 1.19A 1pxxB-5odbB:
undetectable		 1pxxB-5odbB:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		5 / 10 VAL B  96
LEU B  46
TRP A 114
VAL A  99
GLY A 110
 None
 1.19A 1pxxD-5odbB:
undetectable		 1pxxD-5odbB:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		5 / 12 GLY B  99
GLY B 100
ASP B  92
ASP B  30
GLY B  29
 None
 0.84A 1sqfA-5odbB:
undetectable		 1sqfA-5odbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR A 107
ASP A  33
SER A  52
TYR A  53
 None
 1.30A 2bteA-5odbA:
undetectable		 2bteA-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR A 107
ASP A  33
SER A  52
TYR A  53
 None
 1.25A 2bteD-5odbA:
undetectable		 2bteD-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER A 189
THR B 180
GLN A 182
 None
 0.60A 2fk8A-5odbA:
undetectable		 2fk8A-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  95
TYR B  36
PRO B  44
TYR B  87
 None
 0.72A 2oldA-5odbA:
13.0
2oldB-5odbA:
17.5		 2oldA-5odbA:
undetectable
2oldB-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  36
PRO B  44
TYR B  87
TYR A  95
 None
 0.67A 2oldA-5odbB:
26.1
2oldB-5odbB:
19.8		 2oldA-5odbB:
undetectable
2oldB-5odbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 TYR B 192
ARG B 209
SER B 190
 None
 0.58A 4dr2I-5odbB:
undetectable
4dr2J-5odbB:
undetectable		 4dr2I-5odbB:
17.56
4dr2J-5odbB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 TYR B 192
ARG B 209
SER B 190
 None
 1.09A 4khpI-5odbB:
undetectable
4khpJ-5odbB:
undetectable		 4khpI-5odbB:
17.69
4khpJ-5odbB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 TYR B 192
ARG B 209
SER B 190
 None
 0.54A 4lf7I-5odbB:
undetectable
4lf7J-5odbB:
undetectable		 4lf7I-5odbB:
17.56
4lf7J-5odbB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 TYR B 192
ARG B 209
SER B 190
 None
 0.54A 4lf8I-5odbB:
undetectable
4lf8J-5odbB:
undetectable		 4lf8I-5odbB:
17.56
4lf8J-5odbB:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 TYR B  32
TYR B  36
TYR B  49
PRO B  55
 None
None
None
SO4  B 301 (-4.6A)
 0.55A 5aclA-5odbB:
20.4		 5aclA-5odbB:
56.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 GLY B 153
THR B 154
SER B 191
HIS B 189
 None
 0.98A 5ewuA-5odbB:
undetectable		 5ewuA-5odbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		4 / 6 GLY B 153
THR B 154
SER B 191
HIS B 189
 None
 0.85A 5ewuB-5odbB:
undetectable		 5ewuB-5odbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.89A 5jsdB-5odbA:
undetectable		 5jsdB-5odbA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		5 / 8 THR B  18
SER B  76
SER B  63
THR B  72
SER B  65
 None
 1.47A 5l4eA-5odbB:
undetectable
5l4eB-5odbB:
undetectable
5l4eC-5odbB:
undetectable
5l4eD-5odbB:
undetectable
5l4eE-5odbB:
undetectable		 5l4eA-5odbB:
14.39
5l4eB-5odbB:
14.39
5l4eC-5odbB:
14.39
5l4eD-5odbB:
14.39
5l4eE-5odbB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens) 		4 / 8 PRO A 178
THR B 162
THR B 163
PRO B 114
 None
 1.34A 5x2sI-5odbA:
undetectable
5x2sJ-5odbA:
undetectable
5x2sK-5odbA:
undetectable		 5x2sI-5odbA:
21.43
5x2sJ-5odbA:
21.58
5x2sK-5odbA:
21.43