SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5odr'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AXW_A_MTXA732_1 (THYMIDYLATE SYNTHASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	ILE A 324 LEU A 537 GLY A 509 VAL A 504 ALA A 501	None	1.14A	1axwA-5odrA: undetectable	1axwA-5odrA: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CBR_A_REAA200_1 (CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	5 / 12	PHE D  55 LEU D  50 ALA D  54 ALA D  59 LEU D 129	None	1.14A	1cbrA-5odrD: undetectable	1cbrA-5odrD: 17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CBR_B_REAB200_1 (CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	5 / 12	PHE D  55 LEU D  50 ALA D  54 ALA D  59 LEU D 129	None	1.13A	1cbrB-5odrD: undetectable	1cbrB-5odrD: 17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DVX_B_DIFB125_1 (TRANSTHYRETIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	4 / 7	LEU B 275 LEU B 277 SER B 283 SER B 278	None	1.07A	1dvxA-5odrB: undetectable	1dvxA-5odrB: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EE2_A_CHDA1150_0 (ALCOHOL DEHYDROGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 11	CYH E 177 MET E 252 CYH E 207 VAL A 589 ILE E 191	SF4  E 304 (-2.4A) None SF4  E 304 (-2.2A) SF4  A 707 ( 4.1A) None	1.34A	1ee2A-5odrE: undetectable	1ee2A-5odrE: 24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EE2_B_CHDB1250_1 (ALCOHOL DEHYDROGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 11	CYH E 177 MET E 252 CYH E 207 VAL A 589 ILE E 191	SF4  E 304 (-2.4A) None SF4  E 304 (-2.2A) SF4  A 707 ( 4.1A) None	1.35A	1ee2B-5odrE: 2.3	1ee2B-5odrE: 24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_E_ACTE3005_0 (BETA-CARBONIC ANHYDRASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	HIS F  69 GLY F 158 GLY F 159 GLN F 172	None	0.91A	1ekjE-5odrF: undetectable 1ekjF-5odrF: undetectable	1ekjE-5odrF: 19.44 1ekjF-5odrF: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_G_ACTG3002_0 (BETA-CARBONIC ANHYDRASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	HIS F  69 GLY F 158 GLY F 159 GLN F 172	None	0.91A	1ekjG-5odrF: undetectable 1ekjH-5odrF: undetectable	1ekjG-5odrF: 19.44 1ekjH-5odrF: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FO4_A_SALA3005_1 (XANTHINE DEHYDROGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 9	LEU B 260 SER B 261 PHE B 122 VAL B  25 LEU B  29	None	1.47A	1fo4A-5odrB: undetectable	1fo4A-5odrB: 12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_B_115B1_1 (HMG-COA REDUCTASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 9	CYH B  42 LEU B  64 ALA B  88 LEU B  92 LEU B  57	9S8  B 301 (-2.0A) None None None None	1.48A	1hwiA-5odrB: undetectable	1hwiA-5odrB: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HXB_A_ROCA100_1 (HIV-1 PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.86A	1hxbA-5odrF: undetectable	1hxbA-5odrF: 11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	5 / 11	LEU D  92 VAL D  62 CYH D 132 GLY D  61 LEU D  52	None	1.43A	1jkhA-5odrD: undetectable 1jkhB-5odrD: undetectable	1jkhA-5odrD: 13.09 1jkhB-5odrD: 16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JR1_B_MOAB1333_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE 2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	4 / 8	GLY E 217 THR E 220 GLY E 249 GLN E 248	SF4  E 304 ( 3.8A) SF4  E 303 (-4.4A) None None	0.87A	1jr1B-5odrE: undetectable	1jr1B-5odrE: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MNV_D_DVAD8_0 (ACTINOMYCIN D)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	THR F 120 THR F 121 PRO F 119	None	0.84A	1mnvD-5odrF: undetectable	1mnvD-5odrF: 3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N6C_A_SAMA402_0 (SET DOMAIN-CONTAINING PROTEIN 7)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 11	ILE A 241 GLU A 295 LYS A 290 TYR A 217 GLU A 243	SF4  A 703 ( 4.6A) None None None None	1.42A	1n6cA-5odrA: undetectable	1n6cA-5odrA: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	PHE E  82 GLY E 148 SER E 239 ALA E  86 ALA E  87	None None SF4  E 303 (-3.4A) None ACT  E 301 (-4.3A)	1.23A	1nw5A-5odrE: undetectable	1nw5A-5odrE: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1O76_B_CAMB1420_0 (CYTOCHROME P450-CAM)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.12A	1o76B-5odrC: undetectable	1o76B-5odrC: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P9G_A_ACTA42_0 (EAFP 2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	CYH F  64 ARG F 375 CYH F  61	NFU  F 501 (-2.2A) NFU  F 501 (-4.2A) NFU  F 501 (-2.2A)	1.47A	1p9gA-5odrF: undetectable	1p9gA-5odrF: 5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SH9_B_RITB301_2 (POL POLYPROTEIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 10	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.93A	1sh9B-5odrF: undetectable	1sh9B-5odrF: 12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UYU_B_CAMB1416_0 (CYTOCHROME P450-CAM)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.08A	1uyuB-5odrC: undetectable	1uyuB-5odrC: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VM1_A_TAZA504_1 (BETA-LACTAMASE SHV-1)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	ASP A 309 TYR A 240 GLU A 295	None	0.68A	1vm1A-5odrA: undetectable	1vm1A-5odrA: 17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WOP_A_FFOA2887_1 (AMINOMETHYLTRANSFERA SE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	3 / 3	ASP E 247 GLU E 138 ARG A 651	None	0.86A	1wopA-5odrE: undetectable	1wopA-5odrE: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_A_ADNA433_2 (ADENOSYLHOMOCYSTEINA SE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	THR A 287 GLU A 263 HIS A 292	None	0.85A	1xwfA-5odrA: 5.1	1xwfA-5odrA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_B_ADNB433_2 (ADENOSYLHOMOCYSTEINA SE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	THR A 287 GLU A 263 HIS A 292	None	0.84A	1xwfB-5odrA: 5.2	1xwfB-5odrA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_C_ADNC433_2 (ADENOSYLHOMOCYSTEINA SE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	THR A 287 GLU A 263 HIS A 292	None	0.86A	1xwfC-5odrA: undetectable	1xwfC-5odrA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_D_ADND433_2 (ADENOSYLHOMOCYSTEINA SE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	THR A 287 GLU A 263 HIS A 292	None	0.80A	1xwfD-5odrA: 5.2	1xwfD-5odrA: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_B_BEZB12_0 (CES1 PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	GLY A 179 SER A 177 VAL A 206 LEU A 199	None	1.22A	1yajB-5odrA: undetectable	1yajB-5odrA: 22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YRC_A_CAMA420_0 (CYTOCHROME P450-CAM)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.01A	1yrcA-5odrC: undetectable	1yrcA-5odrC: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YRD_A_CAMA420_0 (CYTOCHROME P450-CAM)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.04A	1yrdA-5odrC: undetectable	1yrdA-5odrC: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVV_E_MK1E902_3 (POL POLYPROTEIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.83A	2avvE-5odrF: undetectable	2avvE-5odrF: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_F_SAMF301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	GLY E  95 LEU E 289 GLY E 282 ASP E 279 ALA F  53	None	0.95A	2bm9F-5odrE: undetectable	2bm9F-5odrE: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_F_SAMF301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU F 240 GLY F 376 SER F 293 ALA F 373 ALA F  67	None None None NFU  F 501 (-3.1A) NFU  F 501 ( 4.5A)	1.12A	2br4F-5odrF: undetectable	2br4F-5odrF: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXC_A_P1ZA2001_1 (SERUM ALBUMIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	6 / 12	SER E  13 LEU E  30 LEU E  26 ARG F 147 ALA F 143 ILE F 140	None	1.42A	2bxcA-5odrE: undetectable	2bxcA-5odrE: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DTT_E_H4BE1004_1 (HYPOTHETICAL PROTEIN PH0634)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 11	LEU B 266 VAL B 284 HIS B 280 HIS B 235 THR B 227	None	1.40A	2dttD-5odrB: undetectable 2dttE-5odrB: undetectable	2dttD-5odrB: 23.19 2dttE-5odrB: 23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FEU_B_CAMB1421_0 (CYTOCHROME P450-CAM)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.00A	2feuB-5odrC: undetectable	2feuB-5odrC: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FK8_A_SAMA302_0 (METHOXY MYCOLIC ACID SYNTHASE 4)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY A 155 GLY A 554 GLY A 179 ILE A 325 ALA A 327	None	1.00A	2fk8A-5odrA: undetectable	2fk8A-5odrA: 17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IJ7_A_TPFA2472_1 (CYTOCHROME P450 121)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 11	VAL E 245 ASN E 175 ALA E 255 SER E 258 ARG D  84	None SF4  A 707 (-3.5A) None None None	1.38A	2ij7A-5odrE: undetectable	2ij7A-5odrE: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IJ7_D_TPFD2473_1 (CYTOCHROME P450 121)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 10	VAL E 245 ASN E 175 ALA E 255 SER E 258 ARG D  84	None SF4  A 707 (-3.5A) None None None	1.39A	2ij7D-5odrE: undetectable	2ij7D-5odrE: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IJ7_F_TPFF2474_1 (CYTOCHROME P450 121)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 10	VAL E 245 ASN E 175 ALA E 255 SER E 258 ARG D  84	None SF4  A 707 (-3.5A) None None None	1.40A	2ij7F-5odrE: undetectable	2ij7F-5odrE: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LH8_A_VIBA1_1 (MAJOR PRION PROTEIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 6	PRO F 324 MET F 325 ASP F 440 TYR F 439	None	1.40A	2lh8A-5odrF: undetectable	2lh8A-5odrF: 10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNK_A_ROCA401_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU F  70 GLY F  98 ALA F  99 ILE F  63 PRO F  58	None None None NFU  F 501 ( 4.7A) None	0.99A	2nnkA-5odrF: undetectable	2nnkA-5odrF: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNK_A_ROCA401_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.89A	2nnkA-5odrF: undetectable	2nnkA-5odrF: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNP_A_ROCA401_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 11	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.92A	2nnpA-5odrF: undetectable	2nnpA-5odrF: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_A_H4BA600_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	MET A 519 ARG A  74 ILE A 510 GLU A 520	None	1.46A	2nsiA-5odrA: undetectable 2nsiB-5odrA: undetectable	2nsiA-5odrA: 21.15 2nsiB-5odrA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_B_H4BB601_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	GLU A 520 MET A 519 ARG A  74 ILE A 510	None	1.46A	2nsiA-5odrA: undetectable 2nsiB-5odrA: undetectable	2nsiA-5odrA: 21.15 2nsiB-5odrA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NSI_D_H4BD603_1 (PROTEIN (NITRIC OXIDE SYNTHASE))	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	GLU A 520 MET A 519 ARG A  74 ILE A 510	None	1.48A	2nsiC-5odrA: undetectable 2nsiD-5odrA: undetectable	2nsiC-5odrA: 21.15 2nsiD-5odrA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_B_SAMB300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	6 / 12	GLY A 329 GLY A 554 GLY A 155 GLY A 152 THR A 158 LEU A 162	FAD  A 701 (-3.1A) None None FAD  A 701 (-3.4A) None None	1.27A	2oxtB-5odrA: 3.6	2oxtB-5odrA: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PKK_A_2FAA501_2 (ADENOSINE KINASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	4 / 4	ALA E 250 VAL E 245 PHE E 293 THR A 639	None	1.34A	2pkkA-5odrE: 3.6	2pkkA-5odrE: 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PYM_A_1UNA1001_2 (PROTEASE RETROPEPSIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.88A	2pymB-5odrF: undetectable	2pymB-5odrF: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q6H_A_CXXA802_1 (TRANSPORTER)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	SER A 492 ARG A 431 ILE A 430 PHE A 452	None SF4  A 702 (-4.5A) None GOL  A 709 (-4.4A)	1.09A	2q6hA-5odrA: undetectable	2q6hA-5odrA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEB_B_HSMB145_1 (D7R4 PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	4 / 7	ILE B  74 TYR B   3 ASP B 129 GLU B 124	None	1.16A	2qebB-5odrB: undetectable	2qebB-5odrB: 19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEY_A_EV1A1771_1 (CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	HIS E  16 LEU E  35 VAL E 160 GLU E  57 MET E  72	None None None SF4  E 302 (-3.8A) None	1.28A	2weyA-5odrE: undetectable	2weyA-5odrE: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZWT_A_CAMA422_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.03A	2zwtA-5odrC: undetectable	2zwtA-5odrC: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZWU_A_CAMA422_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.02A	2zwuA-5odrC: undetectable	2zwuA-5odrC: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AI8_A_HNQA255_1 (CATHEPSIN B)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	4 / 7	GLY E  58 HIS F  15 HIS E  16 TRP E   8	SF4  E 302 ( 4.9A) None None None	0.84A	3ai8A-5odrE: undetectable	3ai8A-5odrE: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AX9_B_SALB1340_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	LEU F 332 SER F 198 ALA F 112 ALA F 113	None	0.93A	3ax9B-5odrF: undetectable	3ax9B-5odrF: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY A 151 GLY A 155 ILE A 196 GLY A 180 GLY A 179	FAD  A 701 (-4.5A) None None FAD  A 701 (-3.2A) None	0.93A	3axzA-5odrA: undetectable	3axzA-5odrA: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_B_SVRB512_1 (PHOSPHOLIPASE A2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	VAL F 397 VAL F 396 THR F  57 THR F 399	NFU  F 501 (-4.4A) None None NFU  F 501 (-3.7A)	1.14A	3bjwA-5odrF: undetectable	3bjwA-5odrF: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_B_SVRB512_1 (PHOSPHOLIPASE A2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	4 / 5	VAL F 396 VAL F 397 THR E 114 THR F 377	None NFU  F 501 (-4.4A) None None	1.21A	3bjwA-5odrF: undetectable	3bjwA-5odrF: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_E_SVRE510_3 (PHOSPHOLIPASE A2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	VAL F 397 VAL F 396 THR F  57 THR F 399	NFU  F 501 (-4.4A) None None NFU  F 501 (-3.7A)	1.18A	3bjwG-5odrF: undetectable	3bjwG-5odrF: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_E_SVRE510_3 (PHOSPHOLIPASE A2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	4 / 5	VAL F 396 VAL F 397 THR E 114 THR F 377	None NFU  F 501 (-4.4A) None None	1.23A	3bjwG-5odrF: undetectable	3bjwG-5odrF: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_1 (PHOSPHOLIPASE A2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	VAL F 397 VAL F 396 THR F  57 THR F 399	NFU  F 501 (-4.4A) None None NFU  F 501 (-3.7A)	1.19A	3bjwC-5odrF: undetectable	3bjwC-5odrF: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH511_2 (PHOSPHOLIPASE A2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	VAL F 397 VAL F 396 THR F  57 THR F 399	NFU  F 501 (-4.4A) None None NFU  F 501 (-3.7A)	1.14A	3bjwD-5odrF: undetectable	3bjwD-5odrF: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH511_2 (PHOSPHOLIPASE A2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	4 / 5	VAL F 396 VAL F 397 THR E 114 THR F 377	None NFU  F 501 (-4.4A) None None	1.24A	3bjwD-5odrF: undetectable	3bjwD-5odrF: 13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BUF_A_AEGA394_0 (BETA-SECRETASE 1)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	LEU A 199 ILE A 547 ILE A 196 GLY A 179	None FAD  A 701 (-3.2A) None None	0.92A	3bufA-5odrA: undetectable	3bufA-5odrA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_A_H4BA902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	MET A 519 ARG A  74 ILE A 510 GLU A 520	None	1.45A	3e7gA-5odrA: undetectable 3e7gB-5odrA: undetectable	3e7gA-5odrA: 21.23 3e7gB-5odrA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_B_H4BB1902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	GLU A 520 MET A 519 ARG A  74 ILE A 510	None	1.43A	3e7gA-5odrA: undetectable 3e7gB-5odrA: undetectable	3e7gA-5odrA: 21.23 3e7gB-5odrA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_C_H4BC2902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	MET A 519 ARG A  74 ILE A 510 GLU A 520	None	1.41A	3e7gC-5odrA: undetectable 3e7gD-5odrA: undetectable	3e7gC-5odrA: 21.23 3e7gD-5odrA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E7G_D_H4BD3902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	GLU A 520 MET A 519 ARG A  74 ILE A 510	None	1.46A	3e7gC-5odrA: undetectable 3e7gD-5odrA: undetectable	3e7gC-5odrA: 21.23 3e7gD-5odrA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_A_SAMA300_0 (PUTATIVE RRNA METHYLASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F 376 ASN F 290 ASN F 402 GLY F 369 HIS F 380	None	1.14A	3eeyA-5odrF: undetectable	3eeyA-5odrF: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_B_SAMB300_0 (PUTATIVE RRNA METHYLASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F 376 ASN F 290 ASN F 402 GLY F 369 HIS F 380	None	1.14A	3eeyB-5odrF: undetectable	3eeyB-5odrF: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_H_SAMH300_0 (PUTATIVE RRNA METHYLASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F 376 ASN F 290 ASN F 402 GLY F 369 HIS F 380	None	1.13A	3eeyH-5odrF: undetectable	3eeyH-5odrF: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_I_SAMI300_0 (PUTATIVE RRNA METHYLASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F 376 ASN F 290 ASN F 402 GLY F 369 HIS F 380	None	1.13A	3eeyI-5odrF: undetectable	3eeyI-5odrF: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_A_SAMA301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	ILE A 149 GLY A 150 VAL A 172 ALA A 327 VAL A 504	FAD  A 701 (-4.9A) FAD  A 701 (-3.2A) None None None	0.46A	3fpjA-5odrA: undetectable	3fpjA-5odrA: 19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_B_SAMB301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	GLY A 150 THR A 158 GLU A 173 ALA A 327	FAD  A 701 (-3.2A) None FAD  A 701 (-2.9A) None	0.73A	3fpjB-5odrA: 5.1	3fpjB-5odrA: 19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_A_ERYA195_1 (REPRESSOR PROTEIN MPHR(A))	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 5	ARG A 100 ASN A  98 HIS A 102 ALA D  21	SF4  A 705 (-4.1A) None None None	1.26A	3frqA-5odrA: undetectable	3frqA-5odrA: 15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_B_ERYB195_1 (REPRESSOR PROTEIN MPHR(A))	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	ARG A 100 ASN A  98 HIS A 102 ALA D  21	SF4  A 705 (-4.1A) None None None	1.28A	3frqB-5odrA: undetectable	3frqB-5odrA: 15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWF_A_CAMA420_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.00A	3fwfA-5odrC: undetectable	3fwfA-5odrC: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWF_B_CAMB420_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.01A	3fwfB-5odrC: undetectable	3fwfB-5odrC: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWJ_A_CAMA420_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.02A	3fwjA-5odrC: undetectable	3fwjA-5odrC: 18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWV_A_RFXA801_1 (TRANSPORTER)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU E  94 GLY E  93 ILE E 281 ALA E 292 LEU D  95	None	0.97A	3gwvA-5odrE: undetectable	3gwvA-5odrE: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJ3_A_MTXA605_1 (CHAIN A, CRYSTAL STRUCTURE OF DHFR)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU A 488 LEU A 355 THR A 421 ILE A 423 THR A 365	None	1.21A	3hj3A-5odrA: undetectable	3hj3A-5odrA: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IB1_A_IMNA701_1 (LACTOTRANSFERRIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	4 / 4	PRO E  39 THR E   6 GLY E  83 THR E  84	None None SF4  E 302 ( 4.2A) SF4  E 302 (-4.6A)	1.07A	3ib1A-5odrE: undetectable	3ib1A-5odrE: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB2_A_SAMA1102_0 (STRUCTURAL PROTEIN VP3)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F 170 GLY F 171 ALA F  88 ALA F  73 VAL F  82	None	0.99A	3jb2A-5odrF: undetectable	3jb2A-5odrF: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZ0_B_CLYB900_1 (LINCOSAMIDE NUCLEOTIDYLTRANSFERA SE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	TYR A 486 TYR A 426 GLU A 422 ILE A 461	None	1.00A	3jz0B-5odrA: undetectable	3jz0B-5odrA: 17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_B_TFPB202_1 (PROTEIN S100-A4)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	3 / 3	GLU B 206 LEU B 209 ASP B 210	None	0.25A	3ko0A-5odrB: undetectable	3ko0A-5odrB: 14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_S_TFPS202_2 (PROTEIN S100-A4)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	3 / 3	GLU B 206 LEU B 209 ASP B 210	None	0.26A	3ko0T-5odrB: undetectable	3ko0T-5odrB: 14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L63_A_CAMA440_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.00A	3l63A-5odrC: undetectable	3l63A-5odrC: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MNE_A_DEXA784_1 (GLUCOCORTICOID RECEPTOR)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	ARG F 375 MET F 110 LEU E  41 ILE E 156 PHE E  82	NFU  F 501 (-4.2A) None None None None	1.45A	3mneA-5odrF: undetectable	3mneA-5odrF: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N58_D_ADND500_1 (ADENOSYLHOMOCYSTEINA SE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU F 443 THR F 399 LEU F 111 MET F 406 PHE F  33	None NFU  F 501 (-3.7A) None None None	1.49A	3n58D-5odrF: undetectable	3n58D-5odrF: 21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8X_A_NIMA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU F 395 ILE F 379 GLY F 369 ALA F  71 SER F  72	None	1.20A	3n8xA-5odrF: undetectable	3n8xA-5odrF: 23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDT_D_ROCD100_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU F  70 GLY F  98 ALA F  99 ILE F  63 PRO F  58	None None None NFU  F 501 ( 4.7A) None	0.95A	3ndtC-5odrF: undetectable	3ndtC-5odrF: 12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDX_A_RITA100_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.82A	3ndxA-5odrF: undetectable	3ndxA-5odrF: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.86A	3oxcA-5odrF: undetectable	3oxcA-5odrF: 13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P4W_C_DSFC320_1 (GLR4197 PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus)	4 / 8	ILE C  74 ILE C  97 VAL C  68 ILE C  58	None None None SF4  C 201 ( 4.8A)	0.84A	3p4wC-5odrC: undetectable	3p4wC-5odrC: 19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWR_A_ROCA401_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU F  70 GLY F  98 ALA F  99 ILE F  63 PRO F  58	None None None NFU  F 501 ( 4.7A) None	0.98A	3pwrA-5odrF: undetectable	3pwrA-5odrF: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWR_A_ROCA401_1 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY F  14 ILE F  60 GLY F  62 ILE E  17 PRO F 374	None None None None NFU  F 501 (-3.5A)	0.88A	3pwrA-5odrF: undetectable	3pwrA-5odrF: 14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R24_A_SAMA302_1 (2'-O-METHYL TRANSFERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	TYR A 486 ASP A 475 ASP A 424	None	0.77A	3r24A-5odrA: 2.7	3r24A-5odrA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RLB_B_VIBB187_1 (THIT)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 12	GLU B 124 TYR B  82 GLY B 152 VAL B 230 ASN B  79	None None 9S8  B 302 ( 3.8A) None 9S8  B 302 (-4.4A)	1.46A	3rlbB-5odrB: undetectable	3rlbB-5odrB: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQ4_A_SAMA500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	GLU E  57 GLY E  58 SER E  18 CYH F 442 CYH F 445	SF4  E 302 (-3.8A) SF4  E 302 ( 4.9A) None NFU  F 501 (-2.2A) NFU  F 501 (-2.4A)	1.23A	3rq4A-5odrE: undetectable	3rq4A-5odrE: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S8P_B_SAMB500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	GLU E  57 GLY E  58 SER E  18 CYH F 442 CYH F 445	SF4  E 302 (-3.8A) SF4  E 302 ( 4.9A) None NFU  F 501 (-2.2A) NFU  F 501 (-2.4A)	1.28A	3s8pB-5odrE: undetectable	3s8pB-5odrE: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SFU_A_RBVA601_1 (RNA POLYMERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 9	THR A 169 ASN A 211 GLY A 163 ASP A 164 ASP A 161	None	1.34A	3sfuA-5odrA: undetectable	3sfuA-5odrA: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SFU_B_RBVB601_1 (RNA POLYMERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 9	THR A 169 ASN A 211 GLY A 163 ASP A 164 ASP A 161	None	1.33A	3sfuB-5odrA: undetectable	3sfuB-5odrA: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKG_B_ROCB801_2 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	LEU F  70 GLY F  98 ALA F  99 ILE F  63 PRO F  58	None None None NFU  F 501 ( 4.7A) None	0.97A	3tkgB-5odrF: undetectable	3tkgB-5odrF: 13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TMZ_A_06XA503_1 (CYTOCHROME P450 2B4)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 11	ILE A 423 PHE A 383 ILE A 359 GLU A 416 PRO A 378	None	1.05A	3tmzA-5odrA: undetectable	3tmzA-5odrA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNC_A_SALA1338_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 9	LEU B 260 SER B 261 PHE B 122 VAL B  25 LEU B  29	None	1.48A	3uncA-5odrB: undetectable	3uncA-5odrB: 12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNC_B_SALB1338_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 9	LEU B 260 SER B 261 PHE B 122 VAL B  25 LEU B  29	None	1.46A	3uncB-5odrB: undetectable	3uncB-5odrB: 12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V8V_A_SAMA801_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY B  17 SER B 278 VAL B 284 PRO B 272 LEU B 288	None	1.15A	3v8vA-5odrB: undetectable	3v8vA-5odrB: 17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V8V_B_SAMB801_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE L)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 11	GLY B  17 SER B 278 VAL B 284 PRO B 272 LEU B 288	None	1.16A	3v8vB-5odrB: undetectable	3v8vB-5odrB: 17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRH_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.01A	3wrhA-5odrC: undetectable	3wrhA-5odrC: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRJ_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.02A	3wrjA-5odrC: undetectable	3wrjA-5odrC: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRL_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.00A	3wrlA-5odrC: undetectable	3wrlA-5odrC: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRL_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.00A	3wrlE-5odrC: undetectable	3wrlE-5odrC: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRM_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	0.98A	3wrmA-5odrC: undetectable	3wrmA-5odrC: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	TYR C  52 LEU B 207 GLY B 198 ILE C  97 ALA B 196	SF4  C 202 (-4.9A) None COM  B 303 (-4.0A) None 9S8  B 302 ( 4.2A)	1.15A	4a6dA-5odrC: undetectable	4a6dA-5odrC: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AC9_B_DXCB1473_0 (MJ0495-LIKE PROTEIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 11	ILE E 277 ASP E 279 GLY E 282 SER D  49 GLY E 249	None	0.87A	4ac9B-5odrE: 6.4 4ac9C-5odrE: 6.4	4ac9B-5odrE: 23.32 4ac9C-5odrE: 23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AFG_C_QMRC1214_1 (CAPITELLA TELETA ACHBP)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus)	4 / 8	TYR C  84 CYH C  83 ILE C  58 ILE C  97	None SF4  C 202 (-2.3A) SF4  C 201 ( 4.8A) None	1.06A	4afgD-5odrC: undetectable 4afgE-5odrC: undetectable	4afgD-5odrC: 22.73 4afgE-5odrC: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AFG_D_QMRD1214_1 (CAPITELLA TELETA ACHBP)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	5 / 9	VAL D  62 CYH D  12 ILE D   9 ILE D  35 PHE D 115	None	1.47A	4afgC-5odrD: 0.0 4afgD-5odrD: 0.0	4afgC-5odrD: 18.42 4afgD-5odrD: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BUP_A_SAMA500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	GLU E  57 GLY E  58 SER E  18 CYH F 442 CYH F 445	SF4  E 302 (-3.8A) SF4  E 302 ( 4.9A) None NFU  F 501 (-2.2A) NFU  F 501 (-2.4A)	1.26A	4bupA-5odrE: undetectable	4bupA-5odrE: 24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D39_B_ACTB860_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	4 / 6	GLY B 241 ILE B 243 GLN B 281 VAL B 257	None	1.08A	4d39B-5odrB: undetectable	4d39B-5odrB: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7B_A_TCWA1126_1 (TRANSTHYRETIN)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 6	LEU F 326 ALA F 330 SER F 293 THR F 291	None	1.21A	4d7bB-5odrF: undetectable	4d7bB-5odrF: 14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DRI_A_RAPA201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 11	ASP B  35 ARG B  23 VAL B  75 ILE B  74 ILE B  66	None	1.14A	4driA-5odrB: undetectable	4driA-5odrB: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F4D_A_CHDA506_0 (FERROCHELATASE, MITOCHONDRIAL)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 4	PRO E 295 LEU E 289 ILE E 281 ARG F  48	None	1.16A	4f4dA-5odrE: undetectable	4f4dA-5odrE: 22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_B_CQAB301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	GLY F  14 LEU F 443 VAL F  36 GLU F  37	None	0.92A	4fgzB-5odrF: undetectable	4fgzB-5odrF: 20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_B_CQAB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	SER C  51 GLU B 204 GLU B 206 GLY B 195	None	1.03A	4fgzA-5odrC: undetectable 4fgzB-5odrC: undetectable	4fgzA-5odrC: 22.18 4fgzB-5odrC: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUB_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	TYR F 439 ARG F 331 HIS F 328	None	1.26A	4fubA-5odrF: undetectable	4fubA-5odrF: 17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HIV_D_DVAD2_0 (ACTINOMYCIN D)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	THR F 121 PRO F 119 THR F 120	None	0.87A	4hivD-5odrF: undetectable	4hivD-5odrF: 3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J4V_D_SVRD301_1 (NUCLEOCAPSID PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 11	GLY B 223 ASN B 146 ALA B 182 VAL B 185 ILE B 220	None	1.43A	4j4vD-5odrB: undetectable 4j4vE-5odrB: undetectable	4j4vD-5odrB: 22.19 4j4vE-5odrB: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J5J_B_478B401_2 (PROTEASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 10	ALA A 631 GLY A 626 PRO A 599 VAL A 612 VAL A 579	SF4  A 707 ( 4.4A) None SF4  A 706 ( 4.2A) None SF4  A 707 ( 4.5A)	1.07A	4j5jB-5odrA: undetectable	4j5jB-5odrA: 10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JKS_A_ADNA401_2 (PROBABLE SUGAR KINASE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.43A	4jksA-5odrA: 5.4	4jksA-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JKS_B_ADNB401_2 (PROBABLE SUGAR KINASE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.44A	4jksB-5odrA: 4.7	4jksB-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JKU_A_ADNA500_2 (PROBABLE SUGAR KINASE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.43A	4jkuA-5odrA: 5.1	4jkuA-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JX1_F_CAMF502_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 4	TYR C  52 THR C  79 VAL B 200 ILE C  74	SF4  C 202 (-4.9A) None None None	0.88A	4jx1F-5odrC: undetectable	4jx1F-5odrC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_B_ACTB701_0 (RNA (33-MER) RNA POLYMERASE 3D-POL)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	3 / 3	HIS F 102 GLY F  62 ILE E  17	None	0.64A	4k50A-5odrF: undetectable	4k50A-5odrF: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_J_ACTJ701_0 (RNA (33-MER) RNA POLYMERASE 3D-POL)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	3 / 3	HIS F 102 GLY F  62 ILE E  17	None	0.61A	4k50I-5odrF: undetectable	4k50I-5odrF: 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	3 / 3	GLU B  87 TRP B  56 LYS B 157	None	1.35A	4k7aA-5odrB: undetectable	4k7aA-5odrB: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K8C_B_ADNB401_2 (SUGAR KINASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.43A	4k8cB-5odrA: 5.0	4k8cB-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K8K_A_ADNA401_2 (SUGAR KINASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.42A	4k8kA-5odrA: 5.4	4k8kA-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K8K_B_ADNB403_2 (SUGAR KINASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.43A	4k8kB-5odrA: 4.7	4k8kB-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KAL_A_ADNA401_2 (PROBABLE SUGAR KINASE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.43A	4kalA-5odrA: 4.6	4kalA-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KAL_B_ADNB401_2 (PROBABLE SUGAR KINASE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.44A	4kalB-5odrA: 5.4	4kalB-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_A_ACTA803_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	4 / 6	GLY B 241 ILE B 243 GLN B 281 VAL B 257	None	1.04A	4kcnA-5odrB: undetectable	4kcnA-5odrB: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KQ8_A_ASDA602_1 (CYTOCHROME P450 19A1)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 10	ILE E 156 ALA E 157 VAL E  33 MET F 130 LEU E  35	None	1.27A	4kq8A-5odrE: undetectable	4kq8A-5odrE: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4B_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.01A	4l4bA-5odrC: undetectable	4l4bA-5odrC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4C_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	0.97A	4l4cB-5odrC: undetectable	4l4cB-5odrC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4D_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.04A	4l4dA-5odrC: undetectable	4l4dA-5odrC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4E_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.02A	4l4eA-5odrC: undetectable	4l4eA-5odrC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4F_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.01A	4l4fA-5odrC: undetectable	4l4fA-5odrC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LCA_A_ADNA401_2 (PROBABLE SUGAR KINASE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.43A	4lcaA-5odrA: 5.2	4lcaA-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LCA_B_ADNB401_2 (PROBABLE SUGAR KINASE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	SER A 492 LEU A 185 TYR A 406 PRO A 335	None FAD  A 701 (-4.4A) FAD  A 701 (-3.7A) None	1.42A	4lcaB-5odrA: 5.0	4lcaB-5odrA: 19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LNW_A_T3A501_2 (THYROID HORMONE RECEPTOR ALPHA)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	ILE F 379 MET F 227 ARG F 294	None	0.80A	4lnwA-5odrF: undetectable	4lnwA-5odrF: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LNX_A_T3A502_2 (THYROID HORMONE RECEPTOR ALPHA)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	ILE F 379 MET F 227 ARG F 294	None	0.78A	4lnxA-5odrF: undetectable	4lnxA-5odrF: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_2 (PROSTAGLANDIN G/H SYNTHASE 2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	LEU F 335 ARG F 331 MET F 434	None	0.95A	4m11C-5odrF: undetectable	4m11C-5odrF: 20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NOS_C_H4BC2011_1 (INDUCIBLE NITRIC OXIDE SYNTHASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 7	MET A 519 ARG A  74 ILE A 510 GLU A 520	None	1.39A	4nosC-5odrA: undetectable 4nosD-5odrA: undetectable	4nosC-5odrA: 21.60 4nosD-5odrA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYQ_A_3CJA607_1 (LACTOPEROXIDASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	GLN F  65 HIS F 163 ARG F  59	None SF4  E 302 (-4.5A) None	1.25A	4qyqA-5odrF: undetectable	4qyqA-5odrF: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RYA_A_MTLA501_0 (ABC TRANSPORTER SUBSTRATE BINDING PROTEIN (SORBITOL))	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY A 539 ALA A 540 PHE A 518 ALA A 501 VAL A 504	FAD  A 701 (-3.2A) FAD  A 701 (-3.8A) None None None	1.43A	4ryaA-5odrA: undetectable	4ryaA-5odrA: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TVT_A_ASCA303_0 (THAUMATIN-1)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	LEU D  50 GLU D  47 SER D  49 VAL E 245	None	1.23A	4tvtA-5odrD: undetectable	4tvtA-5odrD: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_K_CHDK103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 11	GLU F 179 LEU F 176 LEU F 184 LEU F 346 LEU F  94	None	1.22A	4wg0I-5odrF: undetectable 4wg0J-5odrF: undetectable 4wg0K-5odrF: undetectable	4wg0I-5odrF: 4.64 4wg0J-5odrF: 4.64 4wg0K-5odrF: 4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YHA_B_MZMB303_1 (ALPHA-CARBONIC ANHYDRASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	5 / 10	ASP B 285 HIS B 280 HIS B 235 VAL B 284 LEU B 275	None	1.46A	4yhaB-5odrB: undetectable	4yhaB-5odrB: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY A 151 GLY A 155 ILE A 196 GLY A 180 GLY A 179	FAD  A 701 (-4.5A) None None FAD  A 701 (-3.2A) None	0.96A	4yvgA-5odrA: undetectable	4yvgA-5odrA: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJZ_A_BEZA1001_0 (BENZOATE-COENZYME A LIGASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	ALA A 154 GLY A 539 ALA A 540 GLY A 329	FAD  A 701 (-3.4A) FAD  A 701 (-3.2A) FAD  A 701 (-3.8A) FAD  A 701 (-3.1A)	0.51A	4zjzA-5odrA: 3.2	4zjzA-5odrA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJZ_A_BEZA1001_0 (BENZOATE-COENZYME A LIGASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	VAL A  68 PHE A  80 ALA A  47 GLY A  50	None	0.66A	4zjzA-5odrA: 3.2	4zjzA-5odrA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CPR_B_SAMB402_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	GLU E  57 GLY E  58 SER E  18 CYH F 442 CYH F 445	SF4  E 302 (-3.8A) SF4  E 302 ( 4.9A) None NFU  F 501 (-2.2A) NFU  F 501 (-2.4A)	1.29A	5cprB-5odrE: undetectable	5cprB-5odrE: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0Y_A_FOLA201_1 (CONSERVED HYPOTHETICAL MEMBRANE PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	ARG A 651 LYS A 644 GLU A 647	None	0.76A	5d0yA-5odrA: undetectable	5d0yA-5odrA: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E5K_B_017B201_2 (HIV-1 PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY D  58 ALA D  59 ASP D  60 ILE D  38 ILE D   9	GOL  D 203 (-3.8A) None GOL  D 203 (-3.0A) None None	0.84A	5e5kB-5odrD: undetectable	5e5kB-5odrD: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ENT_C_MIYC901_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB,MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 9	PHE E  82 GLY E  58 ASN E  65 ILE E  56 ALA E  81	None SF4  E 302 ( 4.9A) None None ACT  E 301 ( 4.5A)	1.39A	5entC-5odrE: undetectable	5entC-5odrE: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G5G_B_ACTB1321_0 (PUTATIVE XANTHINE DEHYDROGENASE YAGR MOLYBDENUM-BINDING SU SUBUNIT)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	3 / 3	THR E 242 ASP E 243 ALA E 244	None	0.09A	5g5gB-5odrE: undetectable	5g5gB-5odrE: 22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWZ_D_010D6_0 (N-[(5-METHYLISOXAZOL -3-YL)CARBONYL]ALANY L-L-VALYL-N~1~-((1R, 2Z)-4-(BENZYLOXY)-4- OXO-1-{[(3R)-2-OXOPY RROLIDIN-3-YL]METHYL }BUT-2-ENYL)-L-LEUCI NAMIDE PEDV MAIN PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	MET F  95 HIS F  69 GLY F 159	None	0.87A	5gwzB-5odrF: undetectable	5gwzB-5odrF: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1P_F_DVAF9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	3 / 3	ALA B  60 ASN B  63 LEU B  64	None	0.38A	5i1pA-5odrB: undetectable	5i1pA-5odrB: 9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGJ_A_CTYA402_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	ILE E   4 VAL E  79 ALA E  87 ALA E  81 GLY E 148	None None ACT  E 301 (-4.3A) ACT  E 301 ( 4.5A) None	0.89A	5igjA-5odrE: undetectable	5igjA-5odrE: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGV_A_ZITA404_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	5 / 12	ILE D  37 GLY D  10 ASP D  22 HIS A 102 ILE D 107	None	1.19A	5igvA-5odrD: undetectable	5igvA-5odrD: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_C_FUAC1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	VAL F 228 HIS F 224 VAL F 243	None	0.66A	5jmnC-5odrF: undetectable	5jmnC-5odrF: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_B_6V8B304_0 (PROTEASOME SUBUNIT BETA TYPE-6 PROTEASOME SUBUNIT BETA TYPE-7)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	THR E  84 THR E 288 ALA E 292 SER E 239 THR E 220	SF4  E 302 (-4.6A) None None SF4  E 303 (-3.4A) SF4  E 303 (-4.4A)	1.20A	5lf7V-5odrE: undetectable 5lf7b-5odrE: undetectable	5lf7V-5odrE: 20.06 5lf7b-5odrE: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LF7_N_6V8N305_0 (PROTEASOME SUBUNIT BETA TYPE-6 PROTEASOME SUBUNIT BETA TYPE-7)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	THR E  84 THR E 288 ALA E 292 SER E 239 THR E 220	SF4  E 302 (-4.6A) None None SF4  E 303 (-3.4A) SF4  E 303 (-4.4A)	1.20A	5lf7H-5odrE: undetectable 5lf7N-5odrE: undetectable	5lf7H-5odrE: 20.06 5lf7N-5odrE: 20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNA_D_BZMD301_0 (ISATIN HYDROLASE A)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	ILE D  46 LEU D  50 SER E 258 GLY D  44 GLY A 626	None	1.02A	5nnaD-5odrD: undetectable	5nnaD-5odrD: 15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZX_A_9F2A1102_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 8	THR A 653 GLN A 645 ILE A 646 GLY A 648	None	0.79A	5nzxA-5odrA: undetectable	5nzxA-5odrA: 19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODC_F_ACTF503_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE SUBUNIT A)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	ARG F 241 VAL F 249 ASP F 299 LYS F 319	None	0.45A	5odcF-5odrF: 72.0	5odcF-5odrF: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODC_G_ACTG704_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	ALA A 556 GLN A 542 LYS A 545 GLN A 553	None	1.19A	5odcA-5odrA: 63.7 5odcG-5odrA: 64.1	5odcA-5odrA: 100.00 5odcG-5odrA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODH_G_ACTG710_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	ARG A 145 ILE A 170 TYR A 215 ILE A 317	None	0.38A	5odhG-5odrA: 63.9	5odhG-5odrA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODI_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	3 / 3	HIS D 104 GLU D 105 TRP D 106	ACT  D 202 (-3.8A) ACT  D 202 (-3.8A) ACT  D 202 (-4.6A)	0.16A	5odiD-5odrD: 28.4	5odiD-5odrD: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODI_G_ACTG702_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	GLY A 141 THR A 143 ASN A 229	None	0.10A	5odiG-5odrA: 63.0	5odiG-5odrA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODQ_A_ACTA702_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	LYS A 368 VAL A 369 LYS A 377 SER A 418	None	0.98A	5odqA-5odrA: 66.2	5odqA-5odrA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODQ_A_ACTA703_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	6 / 6	ARG A  81 ARG A  82 ALA A  85 PRO A  91 PHE A 137 GLU A 571	None	0.17A	5odqA-5odrA: 66.2	5odqA-5odrA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODQ_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	3 / 3	HIS D 104 GLU D 105 TRP D 106	ACT  D 202 (-3.8A) ACT  D 202 (-3.8A) ACT  D 202 (-4.6A)	0.18A	5odqD-5odrD: 29.0	5odqD-5odrD: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ODR_D_ACTD202_0 (METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	3 / 3	HIS D 104 GLU D 105 TRP D 106	ACT  D 202 (-3.8A) ACT  D 202 (-3.8A) ACT  D 202 (-4.6A)	0.03A	5odrD-5odrD: 30.1	5odrD-5odrD: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WK9_A_CAMA503_0 (CAMPHOR 5-MONOOXYGENASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 7	THR C  50 LEU B 207 VAL B 200 ASP C  73	None	1.04A	5wk9A-5odrC: undetectable	5wk9A-5odrC: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X23_A_LSNA503_1 (CYTOCHROME P450 2C9)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	PRO A 190 THR A 188 ASN A 192 LYS A 187	None FAD  A 701 (-4.6A) None None	1.23A	5x23A-5odrA: undetectable	5x23A-5odrA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XXI_A_LSNA502_1 (CYTOCHROME P450 2C9)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 6	PRO A 190 THR A 188 ASN A 192 LYS A 187	None FAD  A 701 (-4.6A) None None	1.11A	5xxiA-5odrA: undetectable	5xxiA-5odrA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6APH_A_ADNA501_2 (ADENOSYLHOMOCYSTEINA SE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 5	THR F 303 THR F 100 HIS F  96 LEU F 345	None	1.43A	6aphA-5odrF: undetectable	6aphA-5odrF: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AZ3_1_PAR11801_1 (RRNA ALPHA RIBOSOMAL PROTEIN EL18)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	4 / 4	ARG A 338 ARG A 456 GLY A 455 ARG A 454	GOL  A 708 ( 4.5A) None None None	1.49A	6az3P-5odrA: 0.8	6az3P-5odrA: 9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BEO_A_DHIA4_0 ((DPR)PY(DHI)PKDL(DGN ))	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	3 / 3	TYR F 258 PRO F 255 LEU F 240	None	0.87A	6beoA-5odrF: undetectable	6beoA-5odrF: 8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DH3_A_017A101_0 (PROTEASE)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus)	5 / 12	GLY D  58 ALA D  59 ASP D  60 ILE D  38 ILE D   9	GOL  D 203 (-3.8A) None GOL  D 203 (-3.0A) None None	0.92A	6dh3A-5odrD: undetectable	6dh3A-5odrD: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	4 / 8	ASP E 279 VAL F 363 ARG F  92 GLN F 172	None	1.17A	6fbvD-5odrE: undetectable	6fbvD-5odrE: 12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G2P_A_TRPA502_0 (FLAVIN-DEPENDENT L-TRYPTOPHAN OXIDASE VIOA)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B (Methanothermococ cus thermolithotroph icus)	4 / 7	TYR B  15 HIS B 235 LEU B 277 VAL B 284	None	1.00A	6g2pA-5odrB: undetectable	6g2pA-5odrB: 20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNF_C_QPSC602_2 (-)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT G (Methanothermococ cus thermolithotroph icus)	5 / 12	ASP F  52 ASN E 197 ARG F 357 PRO E 234 GLY E 232	None	1.48A	6gnfC-5odrF: undetectable	6gnfC-5odrF: 23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_C_PCFC607_0 (CYTOCHROME B)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT B HETERODISULFIDE REDUCTASE, SUBUNIT C (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 10	MET C 119 ALA C 118 THR B  58 PHE B  48 VAL B  47	None	1.42A	6hu9C-5odrC: undetectable	6hu9C-5odrC: 16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MA6_A_MYTA603_0 (CYTOCHROME P450 3A4)	5odr	METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT A (Methanothermococ cus thermolithotroph icus)	5 / 6	ARG F 288 SER F 293 ARG F 331 ALA F 330 ALA F 438	None	1.41A	6ma6A-5odrF: undetectable	6ma6A-5odrF: 10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_B_FK5B201_0 (PEPTIDYLPROLYL ISOMERASE)	5odr	HETERODISULFIDE REDUCTASE, SUBUNIT A METHYL-VIOLOGEN REDUCING HYDROGENASE, SUBUNIT D (Methanothermococ cus thermolithotroph icus; Methanothermococ cus thermolithotroph icus)	5 / 12	TYR D  18 ASP D  22 ILE D  35 TYR D  31 ILE A  17	None	1.15A	6mkeB-5odrD: undetectable 6mkeC-5odrD: undetectable	6mkeB-5odrD: 15.28 6mkeC-5odrD: 15.28