SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oe5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 143
GLN A  42
LEU A 122
VAL A 105
LEU A 103
 None
 0.96A 1df7A-5oe5A:
undetectable		 1df7A-5oe5A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 198
PHE A 252
VAL A 250
LEU A 274
ALA A 189
 None
 1.21A 1e3vA-5oe5A:
undetectable		 1e3vA-5oe5A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 250
SER A 216
ALA A 225
SER A 223
LEU A 195
 None
 1.14A 1eqgB-5oe5A:
undetectable		 1eqgB-5oe5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.18A 1gtnM-5oe5A:
undetectable
1gtnN-5oe5A:
undetectable		 1gtnM-5oe5A:
11.81
1gtnN-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.20A 1gtnU-5oe5A:
undetectable
1gtnV-5oe5A:
undetectable		 1gtnU-5oe5A:
11.81
1gtnV-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 379
THR A 341
VAL A 335
 None
 0.96A 1hxbA-5oe5A:
undetectable		 1hxbA-5oe5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 229
VAL A  76
ILE A  39
MET A 213
 None
 1.07A 1opjB-5oe5A:
undetectable		 1opjB-5oe5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 189
ALA A 187
VAL A 353
LEU A 351
LEU A 311
 None
 1.18A 1rlbF-5oe5A:
undetectable		 1rlbF-5oe5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.19A 1utdT-5oe5A:
undetectable
1utdU-5oe5A:
undetectable		 1utdT-5oe5A:
11.81
1utdU-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 309
LEU A 327
PHE A 252
SER A 223
 3UK  A 900 ( 4.1A)
None
None
None
 1.07A 1wrlB-5oe5A:
undetectable		 1wrlB-5oe5A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 223
VAL A 250
LEU A 201
 None
 0.66A 1yajG-5oe5A:
undetectable		 1yajG-5oe5A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 TRP A 221
GLY A 212
LEU A 229
PRO A 220
 None
 1.00A 2dqyA-5oe5A:
undetectable		 2dqyA-5oe5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 216
THR A 304
GLN A 162
 None
3UK  A 900 (-3.7A)
3UK  A 900 ( 4.8A)
 0.79A 2fk8A-5oe5A:
undetectable		 2fk8A-5oe5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 379
THR A 341
VAL A 335
 None
 0.93A 2qakA-5oe5A:
undetectable		 2qakA-5oe5A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 210
GLY A 300
PHE A 188
PHE A 219
 3UK  A 900 ( 3.2A)
3UK  A 900 (-3.8A)
None
None
 0.87A 2qwxA-5oe5A:
2.1
2qwxB-5oe5A:
2.2		 2qwxA-5oe5A:
19.95
2qwxB-5oe5A:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		6 / 9 PHE A 209
TYR A 211
ALA A 278
GLY A 279
GLY A 302
HIS A 308
 3UK  A 900 (-4.2A)
3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 0.30A 2v7bA-5oe5A:
50.9		 2v7bA-5oe5A:
30.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		6 / 9 PHE A 209
TYR A 211
ALA A 278
GLY A 279
GLY A 302
HIS A 308
 3UK  A 900 (-4.2A)
3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 0.28A 2v7bB-5oe5A:
51.0		 2v7bB-5oe5A:
30.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 276
VAL A 250
PHE A 219
ASN A 215
 None
 1.18A 2wekA-5oe5A:
3.1		 2wekA-5oe5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 276
VAL A 250
PHE A 219
ASN A 215
 None
 1.13A 2wekB-5oe5A:
3.4		 2wekB-5oe5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A 366
GLY A 361
GLY A 173
LYS A 172
 None
 1.47A 2y4nB-5oe5A:
16.5		 2y4nB-5oe5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 393
ASP A 299
SER A 277
GLU A 296
ALA A 318
 None
3UK  A 900 (-2.6A)
None
None
None
 1.15A 3axtA-5oe5A:
undetectable		 3axtA-5oe5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 393
SER A 277
GLU A 296
ALA A 318
ASP A 321
 None
 1.14A 3axtA-5oe5A:
undetectable		 3axtA-5oe5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 382
VAL A 353
GLY A 302
PHE A 209
ILE A 301
 3UK  A 900 (-2.0A)
None
3UK  A 900 (-3.4A)
3UK  A 900 (-4.2A)
3UK  A 900 (-4.0A)
 1.14A 3k13A-5oe5A:
undetectable		 3k13A-5oe5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 216
GLY A 224
ALA A 225
SER A 223
LEU A 195
 None
 1.08A 4coxA-5oe5A:
undetectable		 4coxA-5oe5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 216
GLY A 224
ALA A 225
SER A 223
LEU A 195
 None
 1.10A 4coxB-5oe5A:
undetectable		 4coxB-5oe5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 216
GLY A 224
ALA A 225
SER A 223
LEU A 195
 None
 1.08A 4coxC-5oe5A:
undetectable		 4coxC-5oe5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 216
GLY A 224
ALA A 225
SER A 223
LEU A 195
 None
 1.09A 4coxD-5oe5A:
undetectable		 4coxD-5oe5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 7 TYR A 211
ALA A 278
GLY A 279
ILE A 301
GLY A 302
 3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-4.0A)
3UK  A 900 (-3.4A)
 0.38A 4eatA-5oe5A:
49.3		 4eatA-5oe5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		6 / 9 TYR A 211
ALA A 278
GLY A 279
ILE A 301
GLY A 302
HIS A 308
 3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-4.0A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 0.34A 4eatB-5oe5A:
49.4		 4eatB-5oe5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 243
ARG A 247
LEU A 295
LEU A 240
LEU A 251
 None
 1.29A 4or0A-5oe5A:
undetectable		 4or0A-5oe5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 188
ALA A 278
TYR A 258
VAL A 309
GLY A 300
 None
3UK  A 900 ( 2.9A)
None
3UK  A 900 ( 4.1A)
3UK  A 900 (-3.8A)
 1.24A 4xnxA-5oe5A:
undetectable		 4xnxA-5oe5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 302
TYR A 211
SER A 280
ALA A 303
TYR A 378
 3UK  A 900 (-3.4A)
3UK  A 900 (-4.0A)
PEG  A 901 (-3.8A)
3UK  A 900 (-3.4A)
None
 1.36A 4ymgA-5oe5A:
undetectable		 4ymgA-5oe5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 177
ARG A 354
GLY A 355
GLU A 331
 None
 1.14A 5cdqA-5oe5A:
undetectable
5cdqB-5oe5A:
undetectable
5cdqC-5oe5A:
undetectable		 5cdqA-5oe5A:
21.71
5cdqB-5oe5A:
18.61
5cdqC-5oe5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 177
ARG A 354
GLY A 355
GLU A 331
 None
 1.15A 5cdqR-5oe5A:
undetectable
5cdqS-5oe5A:
undetectable
5cdqT-5oe5A:
undetectable		 5cdqR-5oe5A:
21.71
5cdqS-5oe5A:
18.61
5cdqT-5oe5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 157
GLY A  77
HIS A 151
ALA A 158
ILE A  79
 None
 1.14A 5eeuI-5oe5A:
undetectable
5eeuJ-5oe5A:
undetectable		 5eeuI-5oe5A:
11.81
5eeuJ-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.16A 5eeuO-5oe5A:
undetectable
5eeuP-5oe5A:
undetectable		 5eeuO-5oe5A:
11.81
5eeuP-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 157
GLY A  53
HIS A 151
ALA A 158
ILE A  79
 None
 1.20A 5eevF-5oe5A:
undetectable
5eevG-5oe5A:
undetectable		 5eevF-5oe5A:
11.81
5eevG-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 157
GLY A  77
HIS A 151
ALA A 158
ILE A  79
 None
 1.14A 5eevI-5oe5A:
undetectable
5eevJ-5oe5A:
undetectable		 5eevI-5oe5A:
11.81
5eevJ-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5eevO-5oe5A:
undetectable
5eevP-5oe5A:
undetectable		 5eevO-5oe5A:
11.81
5eevP-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 157
GLY A  77
HIS A 151
ALA A 158
ILE A  79
 None
 1.14A 5eewI-5oe5A:
undetectable
5eewJ-5oe5A:
undetectable		 5eewI-5oe5A:
11.81
5eewJ-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5eewO-5oe5A:
undetectable
5eewP-5oe5A:
undetectable		 5eewO-5oe5A:
11.81
5eewP-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5eexO-5oe5A:
undetectable
5eexP-5oe5A:
undetectable		 5eexO-5oe5A:
11.81
5eexP-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5eeyO-5oe5A:
undetectable
5eeyP-5oe5A:
undetectable		 5eeyO-5oe5A:
11.81
5eeyP-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5eezO-5oe5A:
undetectable
5eezP-5oe5A:
undetectable		 5eezO-5oe5A:
11.81
5eezP-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 157
GLY A  53
HIS A 151
ALA A 158
ILE A  79
 None
 1.20A 5ef0F-5oe5A:
undetectable
5ef0G-5oe5A:
undetectable		 5ef0F-5oe5A:
11.81
5ef0G-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5ef0O-5oe5A:
undetectable
5ef0P-5oe5A:
undetectable		 5ef0O-5oe5A:
11.81
5ef0P-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5ef1O-5oe5A:
undetectable
5ef1P-5oe5A:
undetectable		 5ef1O-5oe5A:
11.81
5ef1P-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5ef2O-5oe5A:
undetectable
5ef2P-5oe5A:
undetectable		 5ef2O-5oe5A:
11.81
5ef2P-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  77
HIS A 151
ALA A 158
ILE A  79
ALA A 157
 None
 1.17A 5ef3O-5oe5A:
undetectable
5ef3P-5oe5A:
undetectable		 5ef3O-5oe5A:
11.81
5ef3P-5oe5A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 CYH A 332
ALA A 312
GLY A 300
THR A 323
ASP A 382
 None
None
3UK  A 900 (-3.8A)
3UK  A 900 ( 4.5A)
3UK  A 900 (-2.0A)
 1.37A 5l5zH-5oe5A:
undetectable
5l5zI-5oe5A:
undetectable		 5l5zH-5oe5A:
19.51
5l5zI-5oe5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 CYH A 332
ALA A 312
GLY A 300
THR A 323
ASP A 382
 None
None
3UK  A 900 (-3.8A)
3UK  A 900 ( 4.5A)
3UK  A 900 (-2.0A)
 1.38A 5l5zV-5oe5A:
undetectable
5l5zW-5oe5A:
undetectable		 5l5zV-5oe5A:
19.51
5l5zW-5oe5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 209
GLY A 279
GLY A 302
HIS A 308
 3UK  A 900 (-4.2A)
3UK  A 900 (-3.2A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 1.03A 5n9xA-5oe5A:
40.9		 5n9xA-5oe5A:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 127
GLN A  42
TYR A  38
ASP A 109
 None
 1.07A 5vlmE-5oe5A:
undetectable		 5vlmE-5oe5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.14A 5vooA-5oe5A:
undetectable		 5vooA-5oe5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.09A 5vooB-5oe5A:
undetectable		 5vooB-5oe5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.13A 5vooC-5oe5A:
undetectable		 5vooC-5oe5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.14A 5vooD-5oe5A:
undetectable		 5vooD-5oe5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.12A 5vooE-5oe5A:
undetectable		 5vooE-5oe5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.09A 5vooF-5oe5A:
undetectable		 5vooF-5oe5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 239
LEU A 243
GLY A 253
SER A 277
ILE A 257
 None
 1.07A 5vopB-5oe5A:
undetectable		 5vopB-5oe5A:
23.15