SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oed'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5oed RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		5 / 12 ILE B  82
PHE B 103
ILE B 136
PRO B 137
LEU B 124
 None
 1.14A 1dhfA-5oedB:
undetectable		 1dhfA-5oedB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5oed GTGE
(Salmonella
enterica) 		5 / 11 ILE A 155
GLY A 157
ILE A  25
PRO A 175
VAL A  52
 None
 1.04A 2nnpB-5oedA:
undetectable		 2nnpB-5oedA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5oed RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		4 / 8 ILE B  82
ILE B  31
ALA B 102
TRP B  80
 None
 0.97A 4ou1A-5oedB:
undetectable		 4ou1A-5oedB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5oed RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens) 		4 / 7 ASP B  81
ILE B  82
GLY B  32
THR B  39
 MG  A 901 ( 3.7A)
None
None
MG  A 901 ( 3.2A)
 0.96A 4zxiA-5oedB:
4.2		 4zxiA-5oedB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5oed GTGE
RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens;
Salmonella
enterica) 		4 / 6 PHE B  88
ARG B  87
GLU B  86
GLU A 198
 None
None
GDP  B 900 (-4.0A)
None
 1.21A 5h4dA-5oedB:
3.2		 5h4dA-5oedB:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5oed GTGE
RAS-RELATED PROTEIN
RAB-32
(Salmonella
enterica;
Homo
sapiens) 		4 / 8 TYR A  42
ASP A  35
THR A  37
VAL B  66
 None
None
None
MLY  B  65 ( 3.1A)
 1.12A 5ov9B-5oedA:
undetectable		 5ov9B-5oedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5oed GTGE
RAS-RELATED PROTEIN
RAB-32
(Salmonella
enterica;
Homo
sapiens) 		4 / 4 TYR B  54
ARG B  55
THR B  57
LEU A 150
 None
 1.44A 5wauj-5oedB:
undetectable		 5wauj-5oedB:
undetectable