SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oes'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		5 / 12 VAL A  80
ALA A  81
PHE A  84
LEU A 154
ILE A 437
 None
 1.02A 2h42C-5oesA:
undetectable		 2h42C-5oesA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		4 / 7 LEU A 435
LEU A 482
ILE A 190
MET A 458
 None
 0.94A 2qqdA-5oesA:
undetectable
2qqdE-5oesA:
undetectable		 2qqdA-5oesA:
26.39
2qqdE-5oesA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		4 / 8 SER A 138
VAL A  88
TYR A 140
ASN A 451
 None
 1.26A 2wekA-5oesA:
undetectable		 2wekA-5oesA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		4 / 8 SER A 138
VAL A  88
TYR A 140
ASN A 451
 None
 1.24A 2wekB-5oesA:
undetectable		 2wekB-5oesA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		3 / 3 TYR A 438
GLY A 436
ASP A 139
 None
None
MG  A 504 (-3.7A)
 0.71A 3ou6C-5oesA:
undetectable		 3ou6C-5oesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		4 / 4 LEU A 457
GLY A 436
LEU A 435
GLU A 434
 None
None
None
ADP  A 501 ( 2.7A)
 0.87A 3tgvB-5oesA:
undetectable		 3tgvB-5oesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		4 / 6 MET A 458
LEU A 435
GLN A  76
TYR A 140
 None
 1.32A 3vkxA-5oesA:
undetectable		 3vkxA-5oesA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		3 / 3 LYS A 372
PRO A 373
LYS A 318
 ADP  A 501 (-2.9A)
None
ADP  A 501 (-3.9A)
 1.47A 4dr5L-5oesA:
undetectable		 4dr5L-5oesA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		3 / 3 LYS A 372
PRO A 373
LYS A 318
 ADP  A 501 (-2.9A)
None
ADP  A 501 (-3.9A)
 1.44A 4dr6L-5oesA:
undetectable		 4dr6L-5oesA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		3 / 3 LYS A 372
PRO A 373
LYS A 318
 ADP  A 501 (-2.9A)
None
ADP  A 501 (-3.9A)
 1.46A 4duzL-5oesA:
undetectable		 4duzL-5oesA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		3 / 3 LYS A 372
PRO A 373
LYS A 318
 ADP  A 501 (-2.9A)
None
ADP  A 501 (-3.9A)
 1.44A 4dv7L-5oesA:
undetectable		 4dv7L-5oesA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		4 / 5 LEU A 350
GLY A 349
ILE A 152
GLN A 151
 None
None
ADP  A 501 (-3.9A)
None
 1.15A 4ma8C-5oesA:
undetectable		 4ma8C-5oesA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		5 / 12 ILE A  83
GLU A  86
ARG A  90
CYH A 346
LEU A 330
 None
 1.25A 5fhzD-5oesA:
undetectable		 5fhzD-5oesA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		3 / 3 HIS A  16
ASP A  14
HIS A 417
 None
 0.78A 5n1tW-5oesA:
undetectable		 5n1tW-5oesA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5oes GLUTATHIONE
SYNTHETASE
(Solanum
tuberosum) 		4 / 7 HIS A 136
THR A 156
ARG A 443
ASP A  89
 None
 1.34A 6mn4E-5oesA:
undetectable		 6mn4E-5oesA:
undetectable