SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5of3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		5 / 12 THR B 236
ILE B 235
VAL B 260
ASN B 256
LEU B 226
 None
 1.23A 1wsvB-5of3B:
undetectable		 1wsvB-5of3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5of3 UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 11 VAL C  79
LEU C  64
TYR C  83
VAL C  87
TYR C  57
 None
 1.36A 3mbhA-5of3C:
undetectable		 3mbhA-5of3C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5of3 UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 VAL C  79
LEU C  64
TYR C  83
VAL C  87
TYR C  57
 None
 1.35A 3mbhB-5of3C:
undetectable		 3mbhB-5of3C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5of3 UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 VAL C  79
LEU C  64
TYR C  83
VAL C  87
TYR C  57
 None
 1.33A 3mbhC-5of3C:
undetectable		 3mbhC-5of3C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5of3 UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 VAL C  79
LEU C  64
TYR C  83
VAL C  87
TYR C  57
 None
 1.35A 3mbhD-5of3C:
undetectable		 3mbhD-5of3C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5of3 UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 VAL C  79
LEU C  64
TYR C  83
VAL C  87
TYR C  57
 None
 1.36A 3mbhE-5of3C:
undetectable		 3mbhE-5of3C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5of3 UNCHARACTERIZED
PROTEIN
(Sulfolobus
solfataricus) 		5 / 11 VAL C  79
LEU C  64
TYR C  83
VAL C  87
TYR C  57
 None
 1.41A 3mbhF-5of3C:
undetectable		 3mbhF-5of3C:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		5 / 9 LEU B  14
TYR B  68
ILE B  76
ARG B  85
VAL B 188
 None
 1.45A 3oxzA-5of3B:
undetectable		 3oxzA-5of3B:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		4 / 7 ASN B 105
GLU B 103
GLU B 104
ARG B 119
 None
 1.10A 4mi4B-5of3B:
undetectable
4mi4C-5of3B:
undetectable		 4mi4B-5of3B:
16.84
4mi4C-5of3B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		4 / 8 ASN B 105
GLU B 103
GLU B 104
ARG B 119
 None
 1.10A 4mj8B-5of3B:
undetectable
4mj8C-5of3B:
undetectable		 4mj8B-5of3B:
19.19
4mj8C-5of3B:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		4 / 7 ILE B 191
LEU B  72
ASN B  78
ILE B  76
 None
 0.81A 4rmjA-5of3B:
undetectable		 4rmjA-5of3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		3 / 3 GLU B  90
ALA B  91
PHE B  94
 None
 0.64A 4v1fA-5of3B:
undetectable		 4v1fA-5of3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		4 / 8 THR B  70
TYR B  60
PRO B   9
TYR B  86
 None
 1.00A 5v4vA-5of3B:
undetectable		 5v4vA-5of3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5of3 DNA PRIMASE LARGE
SUBUNIT PRIL
(Sulfolobus
solfataricus) 		4 / 8 THR B  70
TYR B  60
PRO B   9
TYR B  86
 None
 1.00A 5v4vB-5of3B:
undetectable		 5v4vB-5of3B:
undetectable