SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5of4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.74A 1a7yA-5of4D:
undetectable		 1a7yA-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.64A 1a7yB-5of4D:
undetectable		 1a7yB-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.78A 1a7yB-5of4D:
undetectable		 1a7yB-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 5 THR B  31
GLU B  27
THR B 480
LEU B  52
 None
 1.39A 1d4fC-5of4B:
undetectable		 1d4fC-5of4B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.83A 1dscC-5of4D:
undetectable		 1dscC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.79A 1dscC-5of4D:
undetectable		 1dscC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.82A 1fjaC-5of4D:
undetectable		 1fjaC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.83A 1fjaD-5of4D:
undetectable		 1fjaD-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.81A 1i3wE-5of4D:
undetectable		 1i3wE-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.76A 1i3wE-5of4D:
undetectable		 1i3wE-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.73A 1i3wF-5of4D:
undetectable		 1i3wF-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.77A 1i3wG-5of4D:
undetectable		 1i3wG-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.70A 1i3wG-5of4D:
undetectable		 1i3wG-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.71A 1i3wH-5of4D:
undetectable		 1i3wH-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 12 THR E  70
GLY E  67
GLU E  72
SER E 172
ASP E  66
 None
 1.14A 1jdvE-5of4E:
undetectable
1jdvF-5of4E:
undetectable		 1jdvE-5of4E:
19.30
1jdvF-5of4E:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.73A 1mnvD-5of4D:
undetectable		 1mnvD-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.72A 1mnvD-5of4D:
undetectable		 1mnvD-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.83A 1ovfB-5of4D:
undetectable		 1ovfB-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens) 		5 / 10 LEU A 717
ALA A 719
LEU A 532
LEU A 533
ILE A 525
 None
 1.28A 1pcgA-5of4A:
undetectable		 1pcgA-5of4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.74A 1qfiA-5of4D:
undetectable		 1qfiA-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.85A 1qfiB-5of4D:
undetectable		 1qfiB-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B 693
SER B 458
GLU B  27
TYR B  24
SER B  23
 None
 1.46A 1s2aA-5of4B:
undetectable		 1s2aA-5of4B:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.67A 1unjF-5of4D:
undetectable		 1unjF-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.70A 1unjF-5of4D:
undetectable		 1unjF-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.70A 1unjL-5of4D:
undetectable		 1unjL-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.71A 1unjL-5of4D:
undetectable		 1unjL-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.67A 1unjR-5of4D:
undetectable		 1unjR-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.66A 1unjR-5of4D:
undetectable		 1unjR-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.77A 1unjW-5of4D:
undetectable		 1unjW-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.67A 1unjX-5of4D:
undetectable		 1unjX-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.69A 1unjX-5of4D:
undetectable		 1unjX-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.75A 1unmE-5of4D:
undetectable		 1unmE-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.75A 1unmE-5of4D:
undetectable		 1unmE-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.70A 1unmF-5of4D:
undetectable		 1unmF-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.68A 1unmF-5of4D:
undetectable		 1unmF-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 386
THR D 388
PRO D 385
 None
 0.83A 209dC-5of4D:
undetectable		 209dC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 4 GLN B 347
GLU B 419
ILE B 432
PRO B 431
 None
 1.34A 2fcnA-5of4B:
undetectable		 2fcnA-5of4B:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 7 TYR B 625
GLY B 622
THR B 540
ASP B 681
 None
 0.97A 2g70A-5of4B:
undetectable		 2g70A-5of4B:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 7 TYR B 625
GLY B 622
THR B 540
ASP B 681
 None
 0.90A 2g70B-5of4B:
undetectable		 2g70B-5of4B:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
 None
 1.15A 2q72A-5of4B:
1.5		 2q72A-5of4B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
 None
 1.12A 2qb4A-5of4B:
undetectable		 2qb4A-5of4B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 11 LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
 None
 1.14A 2qjuA-5of4B:
0.7		 2qjuA-5of4B:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		4 / 7 TYR E 219
ILE E 199
ILE E 169
HIS E 235
 None
 1.10A 2zm7A-5of4E:
undetectable		 2zm7A-5of4E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.85A 316dC-5of4D:
undetectable		 316dC-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 12 LEU E  81
THR E  82
ASP E 136
ALA E 134
ILE E 106
 None
 1.12A 3a35A-5of4E:
undetectable		 3a35A-5of4E:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 12 LEU E  81
THR E  82
ASP E 136
ALA E 134
ILE E 106
 None
 1.13A 3a35B-5of4E:
undetectable		 3a35B-5of4E:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 12 LEU E 145
ALA E 203
VAL E 221
THR E 215
ILE E 182
 None
 0.97A 3czhB-5of4E:
undetectable		 3czhB-5of4E:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
 None
 1.19A 3gwuA-5of4B:
0.9		 3gwuA-5of4B:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B 567
ILE B 535
SER B 528
LEU B 524
LEU B 597
 None
 1.15A 3k2hA-5of4B:
undetectable		 3k2hA-5of4B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 6 ALA B 236
ILE B 239
VAL B 454
HIS B  37
 None
 0.84A 3nneG-5of4B:
undetectable		 3nneG-5of4B:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		4 / 5 GLU E 119
LEU E 120
HIS E 127
GLY E 105
 None
 1.07A 3pp1A-5of4E:
undetectable		 3pp1A-5of4E:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens) 		4 / 8 PHE A 541
ILE A 626
LEU A 575
PHE A 606
 None
 0.83A 3rqwI-5of4A:
undetectable
3rqwJ-5of4A:
undetectable		 3rqwI-5of4A:
18.26
3rqwJ-5of4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 5 ASP B 257
LEU B 256
ILE B 432
PRO B 431
 None
 0.98A 3s3vA-5of4B:
undetectable		 3s3vA-5of4B:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 5 THR B 457
GLY B 459
PRO B  43
TYR B  24
 None
 1.06A 3u8qA-5of4B:
undetectable		 3u8qA-5of4B:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 11 THR E  70
GLY E  67
GLU E  72
SER E 172
ASP E  66
 None
 1.15A 3uawA-5of4E:
2.6		 3uawA-5of4E:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 9 ILE E 169
LEU E 145
ILE E 182
TYR B 614
ILE E 186
 None
 1.27A 3zosB-5of4E:
undetectable		 3zosB-5of4E:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE B 432
GLN B 347
ILE B 417
PHE B 357
TYR B 339
 None
 1.28A 4a79A-5of4B:
undetectable		 4a79A-5of4B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE B 432
GLN B 347
ILE B 417
PHE B 357
TYR B 339
 None
 1.28A 4a79B-5of4B:
undetectable		 4a79B-5of4B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 11 ILE B 432
GLN B 347
ILE B 417
PHE B 357
TYR B 339
 None
 1.23A 4a7aA-5of4B:
undetectable		 4a7aA-5of4B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		4 / 7 ILE E 170
PHE E  91
TYR E 228
HIS E 227
 None
 0.98A 4a97A-5of4E:
undetectable		 4a97A-5of4E:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		4 / 6 ILE E 170
PHE E  91
TYR E 228
HIS E 227
 None
 1.06A 4a97I-5of4E:
undetectable		 4a97I-5of4E:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B 567
LEU B 597
ILE B 561
SER B 541
THR B 540
 None
 1.13A 4f4dB-5of4B:
undetectable		 4f4dB-5of4B:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 11 ARG A 325
SER E 202
ASP E  75
ARG E  80
GLU B 712
 None
 1.44A 4feuB-5of4A:
0.0
4feuE-5of4A:
0.0		 4feuB-5of4A:
20.36
4feuE-5of4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 THR D 388
PRO D 385
THR D 386
 None
 0.77A 4hivD-5of4D:
undetectable		 4hivD-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 ASP B 131
CYH B 134
ALA B 139
PHE B 193
LEU B 107
 None
SF4  B1000 (-2.3A)
None
SF4  B1000 (-4.9A)
None
 1.45A 4iaqA-5of4B:
2.3		 4iaqA-5of4B:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 12 PHE E  91
TYR E  95
ASN E 123
LEU E 120
LEU E 168
 None
 1.35A 4k39A-5of4E:
undetectable		 4k39A-5of4E:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 325
LYS A 326
LYS A 322
 None
 1.27A 4k50A-5of4A:
undetectable		 4k50A-5of4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 325
LYS A 326
LYS A 322
 None
 1.34A 4k50I-5of4A:
undetectable		 4k50I-5of4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		4 / 6 VAL E 167
VAL E  64
ILE E 107
LEU E 120
 None
 1.00A 4l1wB-5of4E:
undetectable		 4l1wB-5of4E:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 10 ARG B 196
VAL B 205
TYR B 211
ALA B 195
SER B 198
 None
 1.08A 4ph9A-5of4B:
undetectable		 4ph9A-5of4B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 10 ARG B 196
VAL B 205
TYR B 211
ALA B 195
SER B 198
 None
 1.05A 4ph9B-5of4B:
undetectable		 4ph9B-5of4B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		4 / 5 TYR E 228
ILE E 170
THR E  84
TYR E 219
 None
 1.00A 4qwpB-5of4E:
undetectable		 4qwpB-5of4E:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG B 666
GLN B 662
GLU B 235
 None
 0.79A 4tvtA-5of4B:
undetectable		 4tvtA-5of4B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		3 / 3 MET B 657
ASP B 681
PHE B 621
 None
 1.07A 4xeyA-5of4B:
undetectable		 4xeyA-5of4B:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B 597
ILE B 595
ILE B 535
ILE B 619
LEU B 558
 None
 0.93A 4y0pA-5of4B:
undetectable		 4y0pA-5of4B:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 324
ARG A 325
ARG B 497
 None
 0.96A 4yiaB-5of4A:
undetectable		 4yiaB-5of4A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens) 		4 / 7 ASN A 576
LYS A 577
TYR A 579
PHE A 561
 None
 1.19A 4yv5B-5of4A:
undetectable		 4yv5B-5of4A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens) 		4 / 8 ASN A 539
PRO A 538
PHE A 703
SER A 704
 None
 1.38A 5amiB-5of4A:
undetectable		 5amiB-5of4A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 9 TYR B 584
ILE B 595
GLY B 593
ILE B 535
ALA B 537
 None
 1.37A 5cf9B-5of4B:
undetectable		 5cf9B-5of4B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 10 GLY E 200
SER E 202
LEU E 201
LEU E  76
ARG E  80
 None
 1.20A 5hwkA-5of4E:
undetectable		 5hwkA-5of4E:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 10 GLY E 200
SER E 202
LEU E 201
LEU E  76
ARG E  80
 None
 1.20A 5hwkB-5of4E:
undetectable		 5hwkB-5of4E:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		3 / 3 VAL E  92
SER E 121
MET E  58
 None
 0.82A 5ikqA-5of4E:
undetectable		 5ikqA-5of4E:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 11 VAL B  83
THR B  76
GLU B  79
TYR B  72
LEU B  53
 None
 1.39A 5jh7B-5of4B:
undetectable		 5jh7B-5of4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 11 VAL B  83
THR B  76
GLU B  79
TYR B  72
LEU B  53
 None
 1.42A 5jh7D-5of4B:
undetectable		 5jh7D-5of4B:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 ARG B 196
VAL B 205
TYR B 211
ALA B 195
SER B 198
 None
 1.08A 5jvzB-5of4B:
undetectable		 5jvzB-5of4B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 6 TYR B 674
PHE B 728
ARG B 487
GLY B 675
 None
 0.98A 5mraA-5of4B:
undetectable
5mraB-5of4B:
undetectable		 5mraA-5of4B:
12.24
5mraB-5of4B:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 9 SER B  23
THR B 482
THR B  46
ILE B  17
SER B  51
 None
 1.32A 5muoA-5of4B:
2.5
5muoB-5of4B:
2.5
5muoC-5of4B:
undetectable
5muoD-5of4B:
undetectable
5muoE-5of4B:
2.5		 5muoA-5of4B:
7.76
5muoB-5of4B:
7.76
5muoC-5of4B:
7.76
5muoD-5of4B:
7.76
5muoE-5of4B:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A 441
THR A 467
LEU A 466
VAL A 351
 None
 1.01A 5ov9A-5of4A:
undetectable		 5ov9A-5of4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens) 		5 / 12 ASP E 178
PHE E 171
VAL E 167
LEU E 211
VAL E 207
 None
 1.16A 5tudD-5of4E:
undetectable		 5tudD-5of4E:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B  52
THR B 457
ARG B 666
TYR B 207
GLU B  79
 None
 1.37A 5v1tA-5of4B:
undetectable		 5v1tA-5of4B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		4 / 6 ILE B  71
TYR B 207
ARG B 450
SER B 222
 None
 0.87A 6f6jA-5of4B:
undetectable		 6f6jA-5of4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE B  71
ALA B 218
LEU B 109
ASP B 219
LEU B 220
 None
 1.31A 6ie8A-5of4B:
undetectable		 6ie8A-5of4B:
14.17