SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ofk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 ALA A  21
THR A 295
PHE A  73
 None
 0.77A 2c6nB-5ofkA:
undetectable		 2c6nB-5ofkA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 HIS A 211
GLU A 243
HIS A 245
 None
 0.85A 3ba0A-5ofkA:
undetectable		 3ba0A-5ofkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 MET A  49
THR A  88
VAL A 137
VAL A  74
ILE A  84
 None
None
None
MPD  A 405 ( 3.5A)
None
 1.14A 3em0A-5ofkA:
undetectable		 3em0A-5ofkA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 7 VAL A 124
TYR A 120
GLU A  52
PRO A  51
 None
None
XYP  A 408 ( 4.9A)
None
 1.29A 3hs4A-5ofkA:
undetectable		 3hs4A-5ofkA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 ARG A  17
ALA A 134
GLU A 243
HIS A 245
 None
 0.87A 3mbgB-5ofkA:
undetectable
3mbgC-5ofkA:
undetectable		 3mbgB-5ofkA:
15.90
3mbgC-5ofkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 GLU A 243
HIS A 245
ARG A  17
ALA A 134
 None
 0.87A 3mbgB-5ofkA:
undetectable
3mbgC-5ofkA:
undetectable		 3mbgB-5ofkA:
15.90
3mbgC-5ofkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 12 THR A  44
ILE A 242
PHE A 236
ILE A 142
ALA A 141
 None
 1.18A 3nxuB-5ofkA:
undetectable		 3nxuB-5ofkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		4 / 5 TYR A 185
ASN A 183
TYR A 182
ILE A 196
 XYP  A 412 (-3.6A)
None
None
None
 1.33A 4o0oA-5ofkA:
undetectable		 4o0oA-5ofkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 SER A 304
ASP A 301
GLN A 273
 None
 0.79A 4oltA-5ofkA:
undetectable
4oltB-5ofkA:
undetectable		 4oltA-5ofkA:
21.51
4oltB-5ofkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		3 / 3 GLN A 273
SER A 304
ASP A 301
 None
 0.73A 4qwpA-5ofkA:
undetectable
4qwpB-5ofkA:
undetectable		 4qwpA-5ofkA:
20.90
4qwpB-5ofkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 10 LEU A 299
GLY A 298
ASP A 302
TYR A 303
SER A 304
 None
 1.09A 4xj7C-5ofkA:
undetectable
4xj7D-5ofkA:
undetectable		 4xj7C-5ofkA:
22.13
4xj7D-5ofkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5ofk GLYCOSIDE HYDROLASE
FAMILY 48
(Caldicellulosiru
ptor
bescii) 		5 / 11 THR A 282
LEU A 249
ALA A 335
PHE A  16
VAL A 291
 None
 1.19A 6dryA-5ofkA:
undetectable		 6dryA-5ofkA:
21.35