SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ofn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		4 / 5 MET A  94
ALA A 189
TYR A 185
ASP A  32
 None
 1.16A 1upfC-5ofnA:
undetectable		 1upfC-5ofnA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		6 / 12 LEU A  98
ASP A 101
ILE A 102
ILE A 159
PRO A 168
VAL A 182
 None
 1.49A 2nnkB-5ofnA:
undetectable		 2nnkB-5ofnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		4 / 6 SER A 256
ARG A 320
ILE A 146
PHE A 269
 None
 1.13A 2qeiA-5ofnA:
undetectable		 2qeiA-5ofnA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 ARG B  84
SER B 185
LEU B  74
ARG B 192
 None
 1.10A 3ln1C-5ofnB:
undetectable		 3ln1C-5ofnB:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		5 / 12 VAL A 325
LEU A 322
ILE A 313
VAL A 294
LEU A 295
 None
 1.12A 3w68A-5ofnA:
undetectable		 3w68A-5ofnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		4 / 8 ASP A  97
SER A  96
ARG A  36
GLY A 186
 None
 0.84A 4af0A-5ofnA:
undetectable		 4af0A-5ofnA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU B  31
LEU B  37
ILE B 199
ILE B  76
LEU B 206
 None
 1.10A 4j24A-5ofnB:
undetectable		 4j24A-5ofnB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU B  31
LEU B  37
ILE B 199
ILE B  76
LEU B 206
 None
 1.12A 4j24B-5ofnB:
undetectable		 4j24B-5ofnB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5ofn DNA PRIMASE LARGE
SUBUNIT PRIL,PRIL-X
FUSION PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 ILE B 117
PHE B 138
GLU B 137
CYH B 120
 None
 1.19A 5dqyA-5ofnB:
undetectable		 5dqyA-5ofnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		5 / 12 GLY A 231
VAL A 170
LEU A 266
GLY A 149
ILE A 102
 None
 1.09A 5vooB-5ofnA:
undetectable		 5vooB-5ofnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		5 / 12 GLY A 231
VAL A 170
LEU A 266
GLY A 149
ILE A 102
 None
 1.10A 5vooC-5ofnA:
undetectable		 5vooC-5ofnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		3 / 3 TYR A 138
LEU A 110
ASP A 105
 None
 0.88A 5zv2B-5ofnA:
undetectable		 5zv2B-5ofnA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5ofn DNA PRIMASE SMALL
SUBUNIT PRIS
(Sulfolobus
solfataricus) 		4 / 8 GLY A 149
ILE A 102
ASP A 105
HIS A 106
 None
 1.00A 6ag0C-5ofnA:
undetectable		 6ag0C-5ofnA:
21.43