SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ofq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 5 LEU A 226
GLU A 224
ALA A 219
LEU A 216
 None
 1.17A 1eta1-5ofqA:
undetectable		 1eta1-5ofqA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 5 LEU A 226
GLU A 224
ALA A 219
LEU A 216
 None
 1.10A 1eta2-5ofqA:
undetectable		 1eta2-5ofqA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 ARG A 255
GLY A 253
LEU A 282
PRO A 287
ALA A 138
 None
None
None
HEM  A 501 ( 4.2A)
None
 1.19A 1gseA-5ofqA:
undetectable		 1gseA-5ofqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 GLU A 360
LEU A 356
LEU A 150
GLY A 151
 None
HEM  A 501 ( 4.8A)
None
None
 0.86A 1n13H-5ofqA:
undetectable
1n13K-5ofqA:
undetectable		 1n13H-5ofqA:
14.46
1n13K-5ofqA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 7 LEU A 356
LEU A 150
GLY A 151
GLU A 360
 HEM  A 501 ( 4.8A)
None
None
None
 0.88A 1n13G-5ofqA:
undetectable
1n13J-5ofqA:
undetectable		 1n13G-5ofqA:
11.46
1n13J-5ofqA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ5_A_ACTA2145_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 5 ARG A 255
TYR A 256
TYR A 284
TYR A 285
 None
1PE  A 502 ( 4.7A)
None
None
 0.90A 1pj5A-5ofqA:
0.0		 1pj5A-5ofqA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 7 ALA A 138
PHE A 391
PRO A 286
THR A 281
 None
 1.08A 2q6oA-5ofqA:
undetectable		 2q6oA-5ofqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 8 ILE A 133
PHE A 374
LEU A 368
ARG A 255
 None
 0.85A 2vdbA-5ofqA:
1.0		 2vdbA-5ofqA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ALA A 241
THR A 245
CYH A 351
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.2A)
 0.44A 3e4eA-5ofqA:
30.4		 3e4eA-5ofqA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ALA A 241
THR A 245
CYH A 351
 HEM  A 501 (-3.5A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.2A)
 0.45A 3e4eB-5ofqA:
30.3		 3e4eB-5ofqA:
25.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		5 / 12 SER A  72
LEU A  94
VAL A  98
LEU A 237
LEU A 352
 None
None
None
HEM  A 501 (-4.5A)
HEM  A 501 ( 4.3A)
 0.90A 3r9cA-5ofqA:
42.8		 3r9cA-5ofqA:
34.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 6 ARG A 293
HIS A  91
ARG A  95
ILE A 348
 HEM  A 501 (-2.9A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.8A)
None
 1.50A 5a06A-5ofqA:
undetectable		 5a06A-5ofqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ASP A 260
LEU A 369
ARG A 268
 1PE  A 502 ( 3.9A)
None
None
 0.77A 5e8qA-5ofqA:
undetectable		 5e8qA-5ofqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ARG A  49
PHE A  55
ARG A  44
 None
 1.14A 5y9yA-5ofqA:
undetectable		 5y9yA-5ofqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ASN A 252
PRO A 287
GLN A 289
 None
HEM  A 501 ( 4.2A)
None
 0.94A 6jogA-5ofqA:
undetectable		 6jogA-5ofqA:
21.13