SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ofu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 7 PHE A 322
ALA A 285
ILE A 291
ILE A 135
 None
 0.96A 1oniD-5ofuA:
undetectable
1oniF-5ofuA:
undetectable		 1oniD-5ofuA:
20.85
1oniF-5ofuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 VAL A 180
ASP A 121
HIS A 257
LEU A 261
 None
F6P  A 402 (-2.6A)
None
None
 1.23A 1pk2A-5ofuA:
undetectable		 1pk2A-5ofuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.95A 1rxcB-5ofuA:
undetectable		 1rxcB-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 7 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.97A 1rxcC-5ofuA:
undetectable		 1rxcC-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 7 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.88A 1rxcD-5ofuA:
undetectable		 1rxcD-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.92A 1rxcE-5ofuA:
undetectable		 1rxcE-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 7 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.98A 1rxcF-5ofuA:
undetectable		 1rxcF-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.91A 1rxcI-5ofuA:
undetectable		 1rxcI-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.93A 1rxcK-5ofuA:
undetectable		 1rxcK-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 7 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.92A 1rxcL-5ofuA:
undetectable		 1rxcL-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5ofu FBP PROTEIN
(Leishmania
major) 		5 / 11 HIS A 205
LEU A 260
GLY A 189
ILE A 208
ALA A 295
 None
 1.18A 2yy8A-5ofuA:
undetectable
2yy8B-5ofuA:
undetectable		 2yy8A-5ofuA:
19.09
2yy8B-5ofuA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.89A 3kvvA-5ofuA:
undetectable		 3kvvA-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.88A 3kvvB-5ofuA:
undetectable		 3kvvB-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.83A 3kvvC-5ofuA:
undetectable		 3kvvC-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.93A 3kvvD-5ofuA:
undetectable		 3kvvD-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.91A 3kvvE-5ofuA:
undetectable		 3kvvE-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.94A 3kvvF-5ofuA:
undetectable		 3kvvF-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5ofu FBP PROTEIN
(Leishmania
major) 		5 / 12 ALA A 171
LEU A 192
GLY A 174
ALA A  49
LEU A  73
 None
 1.28A 3tm4A-5ofuA:
undetectable		 3tm4A-5ofuA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5ofu FBP PROTEIN
(Leishmania
major) 		5 / 12 ALA A 171
LEU A 192
GLY A 174
ALA A  49
LEU A  73
 None
 1.25A 3tm4B-5ofuA:
undetectable		 3tm4B-5ofuA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.95A 4e1vA-5ofuA:
undetectable		 4e1vA-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 7 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.96A 4e1vB-5ofuA:
undetectable		 4e1vB-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.94A 4e1vC-5ofuA:
undetectable		 4e1vC-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.94A 4e1vD-5ofuA:
undetectable		 4e1vD-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.95A 4e1vE-5ofuA:
undetectable		 4e1vE-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.96A 4e1vF-5ofuA:
undetectable		 4e1vF-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.95A 4e1vG-5ofuA:
undetectable		 4e1vG-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 GLY A 304
ARG A 335
ILE A 306
VAL A 300
 None
 0.97A 4e1vH-5ofuA:
undetectable		 4e1vH-5ofuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5ofu FBP PROTEIN
(Leishmania
major) 		3 / 3 ARG A 325
LYS A 211
LYS A 210
 None
 1.47A 4k50A-5ofuA:
undetectable		 4k50A-5ofuA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5ofu FBP PROTEIN
(Leishmania
major) 		3 / 3 ARG A 325
LYS A 211
LYS A 210
 None
 1.44A 4k50E-5ofuA:
undetectable		 4k50E-5ofuA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5ofu FBP PROTEIN
(Leishmania
major) 		3 / 3 ARG A 325
LYS A 211
LYS A 210
 None
 1.41A 4k50I-5ofuA:
undetectable		 4k50I-5ofuA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 6 TYR A 244
GLU A 327
TYR A 235
PHE A 334
 None
 1.46A 4twdG-5ofuA:
undetectable
4twdH-5ofuA:
undetectable		 4twdG-5ofuA:
23.28
4twdH-5ofuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		5 / 12 GLY A 162
ILE A 249
GLY A 122
LEU A 279
PHE A 322
 None
CL  A 403 (-4.0A)
F6P  A 402 (-3.6A)
None
None
 1.10A 4zdyA-5ofuA:
undetectable		 4zdyA-5ofuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		5 / 10 LEU A 307
ILE A 306
PRO A 287
ALA A 285
PHE A 322
 None
 1.38A 5m0oA-5ofuA:
undetectable		 5m0oA-5ofuA:
22.22