SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ogx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 10 ALA A  72
GLY A  70
HIS A  54
LEU A  62
PRO A  58
 None
 1.39A 1cmcA-5ogxA:
undetectable
1cmcB-5ogxA:
undetectable		 1cmcA-5ogxA:
undetectable
1cmcB-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 12 LEU A 119
LEU A 180
ILE A 111
HIS A 162
LEU A 161
 None
 1.21A 1g50B-5ogxA:
undetectable		 1g50B-5ogxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 11 LEU A 119
LEU A 180
ILE A 111
HIS A 162
LEU A 161
 None
 1.21A 1g50C-5ogxA:
undetectable		 1g50C-5ogxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		4 / 6 ASP A 204
GLY A 205
PRO A 207
SER A 298
 None
 1.00A 1n4fA-5ogxA:
undetectable		 1n4fA-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		3 / 3 ASP A 247
ARG A 164
ASP A 272
 None
 0.71A 1vptA-5ogxA:
4.0		 1vptA-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 11 HIS A  54
ALA A  57
VAL A  52
GLY A  41
VAL A  85
 None
None
None
FES  A 402 (-3.7A)
None
 1.29A 2uxpB-5ogxA:
undetectable		 2uxpB-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		3 / 3 TYR A 133
GLU A 328
THR A  42
 FAD  A 401 ( 3.8A)
FAD  A 401 ( 4.0A)
None
 0.87A 2y7hB-5ogxA:
1.7		 2y7hB-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 12 ALA A 103
LEU A 159
LEU A 120
LEU A 106
LEU A 126
 None
 1.20A 3erdA-5ogxA:
undetectable		 3erdA-5ogxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 12 GLY A  41
GLY A  38
GLN A  76
ASN A  33
LEU A  45
 FES  A 402 (-3.7A)
FES  A 402 (-3.4A)
None
None
NA  A 403 ( 4.9A)
 1.09A 4fr0A-5ogxA:
5.5		 4fr0A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		3 / 3 ASP A 247
ARG A 164
ASP A 272
 None
 0.77A 4fzvA-5ogxA:
undetectable		 4fzvA-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 12 LEU A 119
LEU A 180
ILE A 111
HIS A 162
LEU A 161
 None
 1.21A 4j24B-5ogxA:
undetectable		 4j24B-5ogxA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		4 / 8 LEU A 119
LEU A 180
HIS A 162
LEU A 161
 None
 1.11A 5dxeA-5ogxA:
undetectable		 5dxeA-5ogxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		7 / 9 SER A 148
THR A 215
GLY A 216
ALA A 218
CYH A 302
GLY A 303
GLU A 328
 FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
None
FAD  A 401 ( 4.1A)
None
None
FAD  A 401 ( 4.0A)
 0.69A 5vw4A-5ogxA:
23.6		 5vw4A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		4 / 8 SER A 148
GLY A 216
CYH A 302
GLY A 303
 FAD  A 401 (-3.2A)
None
None
None
 0.47A 5vw5A-5ogxA:
23.4		 5vw5A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		4 / 8 SER A 148
THR A 215
CYH A 302
GLU A 328
 FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
None
FAD  A 401 ( 4.0A)
 0.70A 5vw5A-5ogxA:
23.4		 5vw5A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		4 / 8 SER A 148
THR A 215
GLY A 216
CYH A 302
 FAD  A 401 (-3.2A)
FAD  A 401 (-3.5A)
None
None
 0.41A 5vw5A-5ogxA:
23.4		 5vw5A-5ogxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		4 / 4 PRO A  79
MET A  31
GLY A  92
VAL A  85
 None
NA  A 403 (-2.8A)
None
None
 1.36A 6ak3A-5ogxA:
undetectable		 6ak3A-5ogxA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		4 / 8 LEU A 119
LEU A 180
HIS A 162
LEU A 161
 None
 1.13A 6cbzA-5ogxA:
undetectable		 6cbzA-5ogxA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5ogx CYTOCHROME P450
REDUCTASE
(Amycolatopsis
methanolica) 		5 / 12 LEU A 159
GLU A 135
ALA A 188
LEU A 122
LEU A 126
 None
None
None
BR  A 404 ( 4.1A)
None
 1.00A 6f6iA-5ogxA:
undetectable
6f6iB-5ogxA:
undetectable		 6f6iA-5ogxA:
18.68
6f6iB-5ogxA:
20.45