SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ohs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5ohs -
(-) 		4 / 6 LEU A 474
HIS A 576
LEU A 622
LEU A 660
 None
 0.93A 1errA-5ohsA:
undetectable		 1errA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.86A 1fbyA-5ohsA:
undetectable		 1fbyA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.86A 1fbyB-5ohsA:
undetectable		 1fbyB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.85A 1fm6A-5ohsA:
undetectable		 1fm6A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.78A 1fm9A-5ohsA:
undetectable		 1fm9A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5ohs -
(-) 		5 / 12 ALA A 106
PHE A 190
ILE A 198
PRO A 130
TYR A 176
 None
 0.97A 1jolB-5ohsA:
undetectable		 1jolB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.81A 1k74A-5ohsA:
undetectable		 1k74A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ohs -
(-) 		5 / 12 ALA A 106
PHE A 190
ILE A 198
PRO A 130
TYR A 176
 None
 1.10A 1rx8A-5ohsA:
undetectable		 1rx8A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 240
ARG A 518
GLN A 530
ARG A 253
 None
 1.47A 1u70A-5ohsA:
undetectable		 1u70A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ohs -
(-) 		4 / 7 LEU A 102
PHE A 188
LEU A  20
SER A 172
 None
 0.79A 1wrlE-5ohsA:
undetectable
1wrlF-5ohsA:
undetectable		 1wrlE-5ohsA:
undetectable
1wrlF-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.88A 1xdkA-5ohsA:
undetectable		 1xdkA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.87A 1xdkE-5ohsA:
undetectable		 1xdkE-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.79A 1xiuA-5ohsA:
undetectable		 1xiuA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.82A 1xlsA-5ohsA:
undetectable		 1xlsA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.82A 1xlsB-5ohsA:
undetectable		 1xlsB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.82A 1xlsC-5ohsA:
undetectable		 1xlsC-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.83A 1xlsD-5ohsA:
undetectable		 1xlsD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.90A 2aclG-5ohsA:
undetectable		 2aclG-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5ohs -
(-) 		5 / 11 ARG A 283
VAL A 138
GLY A 137
LEU A 494
SER A 279
 NSQ  A 709 (-3.3A)
None
None
MPD  A 705 ( 4.5A)
MPD  A 705 ( 3.9A)
 1.14A 2bxeA-5ohsA:
undetectable		 2bxeA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5ohs -
(-) 		5 / 11 ARG A 283
VAL A 138
GLY A 137
LEU A 494
SER A 279
 NSQ  A 709 (-3.3A)
None
None
MPD  A 705 ( 4.5A)
MPD  A 705 ( 3.9A)
 1.13A 2bxgA-5ohsA:
undetectable		 2bxgA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 5ohs -
(-) 		5 / 11 GLY A 454
GLY A 472
THR A 514
PRO A 515
VAL A 516
 None
 0.74A 2nnpA-5ohsA:
undetectable		 2nnpA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5ohs -
(-) 		4 / 7 GLY A 116
GLY A 115
VAL A 444
SER A 476
 None
 0.64A 2oa1B-5ohsA:
undetectable		 2oa1B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5ohs -
(-) 		3 / 3 SER A 559
HIS A 484
ASP A 487
 None
None
NSQ  A 709 ( 4.8A)
 0.74A 2oxtA-5ohsA:
undetectable		 2oxtA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5ohs -
(-) 		4 / 4 LEU A 613
PRO A 614
LEU A 597
ARG A 609
 None
 1.42A 2qd2A-5ohsA:
undetectable		 2qd2A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5ohs -
(-) 		3 / 3 GLN A 570
THR A 468
TRP A 507
 None
 1.18A 2rctA-5ohsA:
undetectable		 2rctA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5ohs -
(-) 		6 / 12 LEU A 538
PHE A 541
ALA A 542
THR A 545
VAL A 264
GLY A 266
 None
 1.24A 2ve3A-5ohsA:
undetectable		 2ve3A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5ohs -
(-) 		4 / 7 SER A 457
ILE A 146
PRO A 136
GLY A 137
 None
 0.94A 2y7kA-5ohsA:
undetectable		 2y7kA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5ohs -
(-) 		3 / 3 MET A 386
GLU A 391
ASN A  44
 NSQ  A 709 (-3.5A)
None
EDO  A 708 ( 4.7A)
 0.83A 3a27A-5ohsA:
undetectable		 3a27A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.99A 3dzyA-5ohsA:
undetectable		 3dzyA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 5ohs -
(-) 		5 / 9 ALA A 387
ASP A 388
GLY A 314
LEU A 313
VAL A 424
 None
NSQ  A 709 (-3.3A)
None
None
None
 0.95A 3em4B-5ohsA:
undetectable		 3em4B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 10 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.87A 3falC-5ohsA:
undetectable		 3falC-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 11 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.93A 3fc6A-5ohsA:
undetectable		 3fc6A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5ohs -
(-) 		3 / 3 CYH A 471
PRO A 572
ASP A 123
 None
 0.87A 3hlwB-5ohsA:
undetectable		 3hlwB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 0.91A 3ln1A-5ohsA:
undetectable		 3ln1A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 0.91A 3ln1B-5ohsA:
undetectable		 3ln1B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 0.89A 3ln1C-5ohsA:
undetectable		 3ln1C-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 0.90A 3nt1A-5ohsA:
undetectable		 3nt1A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 0.90A 3nt1B-5ohsA:
undetectable		 3nt1B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5ohs -
(-) 		4 / 7 VAL A 357
ASN A 420
MET A 377
ILE A 372
 None
 0.94A 3rfmA-5ohsA:
undetectable		 3rfmA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 1.04A 3rr3A-5ohsA:
undetectable		 3rr3A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 1.04A 3rr3C-5ohsA:
undetectable		 3rr3C-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 1.04A 3rr3D-5ohsA:
undetectable		 3rr3D-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ohs -
(-) 		3 / 3 TYR A 161
GLU A 117
TYR A 165
 None
 0.88A 3ug8A-5ohsA:
undetectable		 3ug8A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5ohs -
(-) 		4 / 8 LEU A 551
VAL A 645
TYR A 647
LEU A 660
 None
 0.99A 3v81C-5ohsA:
undetectable		 3v81C-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ohs -
(-) 		5 / 12 LEU A 284
VAL A 138
SER A 153
ASN A 523
TYR A 491
 NSQ  A 709 (-3.6A)
None
MPD  A 705 (-3.0A)
None
NSQ  A 709 (-4.2A)
 1.48A 4amjB-5ohsA:
undetectable		 4amjB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5ohs -
(-) 		5 / 11 THR A 169
PHE A 188
ILE A 198
SER A 186
HIS A 179
 None
 1.44A 4bb2A-5ohsA:
undetectable
4bb2B-5ohsA:
undetectable		 4bb2A-5ohsA:
undetectable
4bb2B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ohs -
(-) 		4 / 6 PHE A 209
LEU A  20
VAL A 104
VAL A 180
 None
 1.05A 4ek1A-5ohsA:
undetectable		 4ek1A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 5ohs -
(-) 		5 / 10 HIS A 463
SER A 120
GLN A 570
HIS A 485
GLY A 453
 None
 1.49A 4lb9A-5ohsA:
1.6		 4lb9A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 5ohs -
(-) 		5 / 12 ALA A 177
ARG A 174
LEU A  20
LEU A 102
ILE A 207
 None
 0.94A 4m2xA-5ohsA:
undetectable		 4m2xA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 5ohs -
(-) 		5 / 12 ALA A 177
ARG A 174
LEU A  20
LEU A 102
ILE A 207
 None
 0.94A 4m2xE-5ohsA:
undetectable		 4m2xE-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5ohs -
(-) 		3 / 3 PRO A 166
ASN A 410
HIS A 409
 None
 0.96A 4ma3H-5ohsA:
2.0
4ma3L-5ohsA:
undetectable		 4ma3H-5ohsA:
undetectable
4ma3L-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.88A 4nqaH-5ohsA:
undetectable		 4nqaH-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ohs -
(-) 		5 / 12 ALA A 106
PHE A 190
ILE A 198
PRO A 130
TYR A 176
 None
 1.03A 4p3qA-5ohsA:
undetectable		 4p3qA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5ohs -
(-) 		3 / 3 CYH A 471
PRO A 572
ASP A 123
 None
 0.96A 4pm5A-5ohsA:
undetectable		 4pm5A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 5ohs -
(-) 		4 / 5 ASP A 234
VAL A 236
TRP A 235
GLU A 432
 None
 1.40A 4qzuA-5ohsA:
0.9
4qzuD-5ohsA:
0.1		 4qzuA-5ohsA:
undetectable
4qzuD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5ohs -
(-) 		4 / 7 GLU A 580
ARG A 632
GLY A 630
GLY A 615
 None
None
SCN  A 702 ( 4.3A)
SCN  A 702 ( 3.8A)
 0.90A 4rdxA-5ohsA:
undetectable		 4rdxA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 5ohs -
(-) 		4 / 4 VAL A 569
ALA A 482
ASN A 481
GLN A 229
 None
 1.44A 4zgfA-5ohsA:
undetectable		 4zgfA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ohs -
(-) 		4 / 6 SER A 120
ASP A 189
ARG A 191
GLY A 126
 None
 0.93A 5cdnC-5ohsA:
undetectable
5cdnD-5ohsA:
undetectable		 5cdnC-5ohsA:
undetectable
5cdnD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ohs -
(-) 		4 / 6 SER A 120
ASP A 189
ARG A 191
GLY A 126
 None
 0.92A 5cdnT-5ohsA:
undetectable
5cdnU-5ohsA:
undetectable		 5cdnT-5ohsA:
undetectable
5cdnU-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5ohs -
(-) 		4 / 4 ARG A 438
TRP A 452
ASP A 487
ARG A 518
 NSQ  A 709 (-3.8A)
NSQ  A 709 (-4.9A)
NSQ  A 709 ( 4.8A)
None
 0.87A 5iefA-5ohsA:
28.0		 5iefA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ohs -
(-) 		5 / 12 LEU A 450
VAL A 469
GLY A 472
ALA A 473
SER A 476
 None
 1.04A 5jvzA-5ohsA:
undetectable		 5jvzA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ohs -
(-) 		5 / 12 GLU A 270
ASP A 487
ALA A 439
ASN A 164
PHE A 389
 NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
None
None
NSQ  A 709 ( 4.8A)
 1.35A 5kc4E-5ohsA:
undetectable		 5kc4E-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 5ohs -
(-) 		4 / 6 TYR A 592
TYR A 590
ASP A 595
HIS A 576
 None
 1.49A 5ov9A-5ohsA:
undetectable		 5ov9A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.89A 5uanA-5ohsA:
undetectable		 5uanA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 5ohs -
(-) 		5 / 12 MET A 544
ALA A 512
LEU A 660
VAL A 598
ASP A 595
 None
 1.47A 5vlmD-5ohsA:
undetectable		 5vlmD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5ohs -
(-) 		4 / 8 GLY A 440
ILE A 451
TRP A 452
GLN A 456
 None
None
NSQ  A 709 (-4.9A)
None
 0.97A 5vlmD-5ohsA:
undetectable		 5vlmD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5ohs -
(-) 		4 / 8 GLY A 440
ILE A 451
TRP A 452
GLN A 456
 None
None
NSQ  A 709 (-4.9A)
None
 0.95A 5vlmH-5ohsA:
undetectable		 5vlmH-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.35A 5x7pA-5ohsA:
22.2		 5x7pA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.31A 5x7pB-5ohsA:
22.1		 5x7pB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.34A 5x7qA-5ohsA:
18.8		 5x7qA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.37A 5x7qB-5ohsA:
22.2		 5x7qB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.32A 5x7rA-5ohsA:
21.9		 5x7rA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ohs -
(-) 		4 / 6 TRP A 452
HIS A 520
GLU A 270
TYR A 315
 NSQ  A 709 (-4.9A)
NSQ  A 709 (-3.9A)
NSQ  A 709 (-2.6A)
NSQ  A 709 ( 4.8A)
 1.31A 5x7rB-5ohsA:
22.3		 5x7rB-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.83A 5z12B-5ohsA:
undetectable		 5z12B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.81A 5z12C-5ohsA:
undetectable		 5z12C-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.79A 6a5yD-5ohsA:
undetectable		 6a5yD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.82A 6a5zD-5ohsA:
undetectable		 6a5zD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ohs -
(-) 		5 / 12 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.83A 6a5zL-5ohsA:
undetectable		 6a5zL-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5ohs -
(-) 		5 / 12 HIS A 653
PHE A 657
GLY A 593
TYR A 483
LEU A 555
 None
 1.03A 6b3aA-5ohsA:
undetectable		 6b3aA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 5ohs -
(-) 		5 / 12 VAL A 138
GLY A 137
SER A 150
LEU A 494
SER A 279
 None
None
None
MPD  A 705 ( 4.5A)
MPD  A 705 ( 3.9A)
 1.30A 6ci6A-5ohsA:
undetectable		 6ci6A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5ohs -
(-) 		4 / 6 ASP A 292
ASN A 376
LEU A 382
PHE A 312
 None
 1.19A 6ekuA-5ohsA:
undetectable		 6ekuA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5ohs -
(-) 		5 / 12 ASP A 487
HIS A 520
GLU A 391
GLU A 117
GLY A 472
 NSQ  A 709 ( 4.8A)
NSQ  A 709 (-3.9A)
None
None
None
 1.48A 6gnfC-5ohsA:
undetectable		 6gnfC-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5ohs -
(-) 		5 / 10 TYR A 483
TYR A 237
TYR A 592
VAL A 569
ALA A 482
 None
 1.45A 6gz9A-5ohsA:
undetectable		 6gz9A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ohs -
(-) 		4 / 5 ILE A  12
LEU A  20
THR A  91
LEU A  90
 None
 0.85A 6nmpN-5ohsA:
undetectable
6nmpW-5ohsA:
undetectable		 6nmpN-5ohsA:
undetectable
6nmpW-5ohsA:
undetectable