SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ohx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 11 ILE A  81
GLY A 218
THR A 219
HIS A 191
GLY A 215
 None
PLP  A 702 (-3.6A)
PLP  A 702 (-4.1A)
None
PLP  A 702 (-3.4A)
 1.04A 1i7qA-5ohxA:
undetectable		 1i7qA-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 10 ILE A  81
GLY A 218
THR A 219
HIS A 191
GLY A 215
 None
PLP  A 702 (-3.6A)
PLP  A 702 (-4.1A)
None
PLP  A 702 (-3.4A)
 1.06A 1i7qC-5ohxA:
undetectable		 1i7qC-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 12 ALA A 319
LEU A 332
GLY A  59
TYR A  58
LEU A  51
 None
 1.13A 1qabF-5ohxA:
undetectable		 1qabF-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 9 GLY A 112
ALA A  82
LEU A 113
TYR A 122
LEU A 179
 None
 1.23A 1y7iA-5ohxA:
undetectable		 1y7iA-5ohxA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		4 / 8 ILE A 199
ILE A 223
LYS A  67
GLU A  69
 None
 0.97A 2j9dJ-5ohxA:
undetectable
2j9dK-5ohxA:
undetectable
2j9dL-5ohxA:
undetectable		 2j9dJ-5ohxA:
undetectable
2j9dK-5ohxA:
undetectable
2j9dL-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		4 / 8 ARG A 298
GLN A 360
GLU A 463
GLU A 350
 None
 1.35A 3dh0A-5ohxA:
undetectable		 3dh0A-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		4 / 6 GLN A 181
TYR A 182
PHE A 268
PRO A   6
 None
 1.39A 3tgvD-5ohxA:
undetectable		 3tgvD-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		4 / 6 GLU A  69
ASP A  79
ASN A 338
ARG A 337
 None
 1.42A 4ntxA-5ohxA:
undetectable
4ntxC-5ohxA:
undetectable		 4ntxA-5ohxA:
10.89
4ntxC-5ohxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 12 ARG A 225
GLY A 213
GLY A 224
GLY A 217
PRO A 333
 HEM  A 701 (-4.0A)
None
None
PLP  A 702 (-3.6A)
PLP  A 702 (-4.0A)
 0.93A 4q5mA-5ohxA:
undetectable		 4q5mA-5ohxA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		4 / 6 ALA A 238
GLY A 215
ILE A 278
VAL A 272
 None
PLP  A 702 (-3.4A)
None
HEM  A 701 (-4.1A)
 0.82A 4r21A-5ohxA:
undetectable		 4r21A-5ohxA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		4 / 7 ALA A  42
THR A  41
TYR A  83
VAL A 119
 None
 1.20A 5ecnA-5ohxA:
undetectable		 5ecnA-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		3 / 3 ASP A  79
ASN A 187
GLN A 181
 None
PLP  A 702 ( 4.1A)
None
 0.73A 5k7uA-5ohxA:
undetectable		 5k7uA-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 12 GLU A 262
VAL A 261
ALA A 310
SER A 289
GLY A 243
 None
 1.13A 5syeB-5ohxA:
undetectable		 5syeB-5ohxA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 11 ASP A 180
GLY A 263
SER A 307
ALA A 310
ASN A 187
 None
PLP  A 702 (-3.7A)
PLP  A 702 (-3.0A)
None
PLP  A 702 ( 4.1A)
 0.94A 6hu9A-5ohxA:
undetectable
6hu9E-5ohxA:
undetectable
6hu9I-5ohxA:
undetectable		 6hu9A-5ohxA:
undetectable
6hu9E-5ohxA:
undetectable
6hu9I-5ohxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5ohx CYSTATHIONINE
BETA-SYNTHASE
(Apis
mellifera) 		5 / 11 ASP A 180
GLY A 263
SER A 307
ALA A 311
ASN A 187
 None
PLP  A 702 (-3.7A)
PLP  A 702 (-3.0A)
None
PLP  A 702 ( 4.1A)
 1.41A 6hu9A-5ohxA:
undetectable
6hu9E-5ohxA:
undetectable
6hu9I-5ohxA:
undetectable		 6hu9A-5ohxA:
undetectable
6hu9E-5ohxA:
undetectable
6hu9I-5ohxA:
undetectable