SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		5 / 12 MET Z 307
LEU Z 372
ILE Z 285
GLY Z 284
LEU Z 281
 None
 1.15A 1g50B-5oikZ:
undetectable		 1g50B-5oikZ:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		4 / 7 ASP Z 289
GLU Z 392
GLU Z 394
GLU Z 556
 None
 0.92A 1knyA-5oikZ:
undetectable
1knyB-5oikZ:
undetectable		 1knyA-5oikZ:
13.06
1knyB-5oikZ:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		4 / 7 ASP Z 289
GLU Z 392
GLU Z 394
GLU Z 556
 None
 1.21A 1knyA-5oikZ:
undetectable
1knyB-5oikZ:
undetectable		 1knyA-5oikZ:
13.06
1knyB-5oikZ:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		4 / 8 GLU Z 556
ASP Z 289
GLU Z 392
GLU Z 394
 None
 1.14A 1knyA-5oikZ:
undetectable
1knyB-5oikZ:
undetectable		 1knyA-5oikZ:
13.06
1knyB-5oikZ:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Homo
sapiens) 		4 / 4 ASP Y  31
ASP Y  37
ASP Y  26
GLY Y  44
 None
 1.22A 2igtC-5oikY:
undetectable		 2igtC-5oikY:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Homo
sapiens) 		4 / 7 LEU Y  40
LEU Y  93
CYH Y  52
SER Y  54
 None
 1.06A 3lm8B-5oikY:
undetectable
3lm8D-5oikY:
undetectable		 3lm8B-5oikY:
19.09
3lm8D-5oikY:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		5 / 11 SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
ILE Z 201
 None
 1.27A 3rf4A-5oikZ:
undetectable
3rf4C-5oikZ:
undetectable		 3rf4A-5oikZ:
8.19
3rf4C-5oikZ:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		5 / 11 ILE Z 201
SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
 None
 1.29A 3rf4A-5oikZ:
undetectable
3rf4B-5oikZ:
undetectable		 3rf4A-5oikZ:
8.19
3rf4B-5oikZ:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		5 / 11 ILE Z 201
SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
 None
 1.30A 3rf4B-5oikZ:
undetectable
3rf4C-5oikZ:
undetectable		 3rf4B-5oikZ:
8.19
3rf4C-5oikZ:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 HIS Y  12
SER Y  56
ASN Z 301
 None
 0.80A 3s8pB-5oikY:
undetectable		 3s8pB-5oikY:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		4 / 8 SER Z 504
LEU Z 506
ASP Z 505
LYS Z 479
 None
 0.93A 4umjA-5oikZ:
undetectable		 4umjA-5oikZ:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		5 / 12 HIS Z 572
ILE Z 550
GLY Z 633
LEU Z 506
THR Z 507
 None
 1.05A 5byjA-5oikZ:
undetectable		 5byjA-5oikZ:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		5 / 12 ILE Z 550
GLY Z 633
THR Z 569
LEU Z 506
THR Z 507
 None
 1.14A 5byjA-5oikZ:
undetectable		 5byjA-5oikZ:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 HIS Y  12
SER Y  56
ASN Z 301
 None
 0.81A 5cprB-5oikY:
undetectable		 5cprB-5oikY:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		4 / 8 MET Y  64
LEU Z 245
ILE Z 239
LEU Y  10
 None
 0.84A 5ieoA-5oikY:
undetectable		 5ieoA-5oikY:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		5 / 9 MET Y  64
VAL Z 182
LEU Z 245
ILE Z 239
LEU Y  10
 None
 0.86A 5iepA-5oikY:
undetectable		 5iepA-5oikY:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens) 		3 / 3 GLN Z 232
TRP Z 180
VAL Z 227
 None
 0.70A 6auuA-5oikZ:
undetectable		 6auuA-5oikZ:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Homo
sapiens) 		5 / 12 TYR Y  85
CYH Y  33
CYH Y  36
LEU Y  21
GLY Y  83
 None
ZN  Y 201 (-2.3A)
ZN  Y 201 (-2.3A)
None
None
 1.30A 6bp4B-5oikY:
undetectable		 6bp4B-5oikY:
16.09