SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oj7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 LEU A 256
ALA A 282
VAL A 297
VAL A 299
 None
 0.81A 1epbB-5oj7A:
undetectable		 1epbB-5oj7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 12 GLY A  61
SER A  65
SER A 157
LEU A 139
HIS A 124
 AR6  A 401 (-3.3A)
None
EDO  A 406 (-2.6A)
None
None
 0.97A 1ya4A-5oj7A:
undetectable		 1ya4A-5oj7A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 6 ALA A  62
SER A  65
ASN A 143
ASP A 145
 AR6  A 401 (-3.6A)
None
None
None
 0.30A 1yc2A-5oj7A:
24.5		 1yc2A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 7 ALA A  62
SER A  65
ILE A  70
ASN A 143
ASP A 145
 AR6  A 401 (-3.6A)
None
None
None
None
 0.30A 1yc5A-5oj7A:
8.9		 1yc5A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 7 SER A  65
ILE A  70
ASP A  72
ASN A 143
ASP A 145
 None
None
AR6  A 401 (-3.7A)
None
None
 0.76A 1yc5A-5oj7A:
8.9		 1yc5A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 5 ALA A  62
ILE A  70
ASN A 143
ASP A 145
 AR6  A 401 (-3.6A)
None
None
None
 0.26A 2h4jA-5oj7A:
22.9		 2h4jA-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.19A 2obvA-5oj7A:
undetectable		 2obvA-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.16A 2p02A-5oj7A:
undetectable		 2p02A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 5 ILE A  89
ARG A 103
ARG A 107
ASP A 203
 EDO  A 404 ( 4.2A)
None
EDO  A 404 ( 3.9A)
EDO  A 404 (-3.6A)
 1.21A 2rhmB-5oj7A:
undetectable		 2rhmB-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 5 ILE A  89
ARG A 103
ARG A 107
ASP A 203
 EDO  A 404 ( 4.2A)
None
EDO  A 404 ( 3.9A)
EDO  A 404 (-3.6A)
 1.24A 2rhmD-5oj7A:
undetectable		 2rhmD-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 12 ILE A  64
GLY A 259
ALA A 291
ILE A 281
VAL A 140
 None
AR6  A 401 (-3.6A)
None
None
None
 1.17A 3adsB-5oj7A:
undetectable		 3adsB-5oj7A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 12 LEU A 262
GLN A 263
ILE A 281
LEU A 294
TYR A 246
 None
 1.36A 3ia4A-5oj7A:
undetectable		 3ia4A-5oj7A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 12 VAL A 297
GLN A  45
PHE A  49
PRO A  40
ILE A 310
 None
 1.19A 3iw1A-5oj7A:
undetectable		 3iw1A-5oj7A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.20A 4kttC-5oj7A:
undetectable		 4kttC-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.15A 4ndnA-5oj7A:
undetectable		 4ndnA-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 7 ILE A  70
LEU A  80
ASN A 143
ASP A 145
 None
 0.57A 4rmjA-5oj7A:
23.1		 4rmjA-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.15A 5a1iA-5oj7A:
undetectable		 5a1iA-5oj7A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 7 SER A  65
PRO A  71
PHE A 115
ASN A 143
 None
 1.24A 5l1fC-5oj7A:
undetectable		 5l1fC-5oj7A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.17A 6fbnB-5oj7A:
undetectable		 6fbnB-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.16A 6fboA-5oj7A:
undetectable		 6fboA-5oj7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 8 HIS A 160
SER A 157
SER A 244
PHE A 241
 GOL  A 407 ( 3.5A)
EDO  A 406 (-2.6A)
EDO  A 406 (-3.3A)
EDO  A 405 ( 3.7A)
 1.16A 6fcdA-5oj7A:
undetectable		 6fcdA-5oj7A:
21.11