SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ojl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.50A 1p93B-5ojlA:
undetectable		 1p93B-5ojlA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		6 / 10 ILE A 137
ALA A 135
ALA A 125
ALA A 132
ILE A  68
CYH A  70
 None
None
9X5  A 301 ( 4.8A)
None
None
None
 1.26A 2aclC-5ojlA:
undetectable		 2aclC-5ojlA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		6 / 11 ILE A 137
ALA A 135
ALA A 125
ALA A 132
ILE A  68
CYH A  70
 None
None
9X5  A 301 ( 4.8A)
None
None
None
 1.22A 2aclE-5ojlA:
undetectable		 2aclE-5ojlA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		6 / 10 ILE A 137
ALA A 135
ALA A 125
ALA A 132
ILE A  68
CYH A  70
 None
None
9X5  A 301 ( 4.8A)
None
None
None
 1.25A 3falA-5ojlA:
undetectable		 3falA-5ojlA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		6 / 10 ILE A 137
ALA A 135
ALA A 125
ALA A 132
ILE A  68
CYH A  70
 None
None
9X5  A 301 ( 4.8A)
None
None
None
 1.28A 3falC-5ojlA:
undetectable		 3falC-5ojlA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		4 / 5 LEU A 107
GLN A  79
LEU A  81
GLU A  78
 None
TXP  A 302 (-3.9A)
None
None
 1.13A 3h5gA-5ojlA:
undetectable
3h5gB-5ojlA:
undetectable		 3h5gA-5ojlA:
undetectable
3h5gB-5ojlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 GLY A 122
LEU A 138
ALA A 168
ASP A 167
SER A 140
 None
 0.98A 3tbgB-5ojlA:
undetectable		 3tbgB-5ojlA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 GLY A 122
LEU A 138
ALA A 168
ASP A 167
SER A 140
 None
 1.00A 3tbgD-5ojlA:
undetectable		 3tbgD-5ojlA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ALA A  43
GLY A  16
GLY A  14
LEU A  72
LEU A  71
 None
TXP  A 302 (-3.3A)
TXP  A 302 (-3.6A)
TXP  A 302 (-4.1A)
TXP  A 302 (-4.2A)
 0.99A 4lg1A-5ojlA:
4.5		 4lg1A-5ojlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ALA A  43
GLY A  16
GLY A  14
LEU A  72
LEU A  71
 None
TXP  A 302 (-3.3A)
TXP  A 302 (-3.6A)
TXP  A 302 (-4.1A)
TXP  A 302 (-4.2A)
 0.98A 4lg1B-5ojlA:
4.7		 4lg1B-5ojlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		6 / 12 LEU A 158
LEU A  66
ILE A  68
LEU A  10
ILE A 123
PHE A  26
 None
None
None
None
TXP  A 302 (-4.3A)
None
 1.50A 4odrA-5ojlA:
undetectable
4odrB-5ojlA:
undetectable		 4odrA-5ojlA:
19.23
4odrB-5ojlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.46A 4p6xA-5ojlA:
undetectable		 4p6xA-5ojlA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.50A 4p6xE-5ojlA:
undetectable		 4p6xE-5ojlA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ASN A  98
GLY A  99
GLN A 103
LEU A 107
ILE A 123
 TXP  A 302 (-3.3A)
None
None
None
TXP  A 302 (-4.3A)
 1.48A 4p6xI-5ojlA:
undetectable		 4p6xI-5ojlA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 11 GLY A 122
LEU A 138
ALA A 168
ASP A 167
SER A 140
 None
 1.16A 4wnuC-5ojlA:
undetectable		 4wnuC-5ojlA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 GLY A 122
LEU A 138
ALA A 168
ASP A 167
SER A 140
 None
 0.88A 4wnwB-5ojlA:
undetectable		 4wnwB-5ojlA:
9.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 TRP A 215
MET A 219
TYR A 222
SER A 240
GLN A 245
 None
 1.06A 5g6sB-5ojlA:
31.6
5g6sC-5ojlA:
31.7		 5g6sB-5ojlA:
50.57
5g6sC-5ojlA:
50.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ojl IMINE REDUCTASE
(Aspergillus
terreus) 		5 / 12 ALA A  60
ILE A  68
ALA A  63
CYH A  70
LEU A  71
 None
None
None
None
TXP  A 302 (-4.2A)
 1.02A 6a5zD-5ojlA:
undetectable		 6a5zD-5ojlA:
23.53