SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ojs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA T1260
ILE T1216
LEU T1193
LEU T1214
GLY T1211
 None
 0.98A 1b02A-5ojsT:
undetectable		 1b02A-5ojsT:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ALA T2559
VAL T2561
TRP T2560
 None
 0.89A 1bdwA-5ojsT:
undetectable
1bdwB-5ojsT:
undetectable		 1bdwA-5ojsT:
0.58
1bdwB-5ojsT:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 THR T3647
ASN T3644
GLY T3639
TYR T2676
 None
 0.81A 1bu5A-5ojsT:
undetectable		 1bu5A-5ojsT:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 THR T3647
ASN T3644
GLY T3639
TYR T2676
 None
 0.79A 1bu5B-5ojsT:
undetectable		 1bu5B-5ojsT:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ALA T2951
VAL T2946
TRP T2945
 None
 0.76A 1c4dA-5ojsT:
undetectable
1c4dB-5ojsT:
undetectable		 1c4dA-5ojsT:
0.58
1c4dB-5ojsT:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP T2945
ALA T2951
VAL T2946
 None
 0.94A 1c4dA-5ojsT:
undetectable
1c4dB-5ojsT:
undetectable		 1c4dA-5ojsT:
0.58
1c4dB-5ojsT:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU T2876
ILE T2877
ARG T2885
 None
 0.79A 1cd2A-5ojsT:
undetectable		 1cd2A-5ojsT:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA T2472
LEU T2606
PHE T2564
SER T2582
LEU T2616
 None
 0.85A 1dreA-5ojsT:
undetectable		 1dreA-5ojsT:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA T2472
PHE T2564
SER T2582
ILE T2583
LEU T2616
 None
 1.30A 1dreA-5ojsT:
undetectable		 1dreA-5ojsT:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE T1511
LEU T1463
PHE T1445
LEU T1477
LEU T1473
 None
 1.14A 1dtlA-5ojsT:
undetectable		 1dtlA-5ojsT:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 GLN T1005
ASN T1002
LEU T1001
SER T1009
 None
 1.19A 1hk2A-5ojsT:
undetectable		 1hk2A-5ojsT:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP T1572
LEU T1579
LEU T1575
 None
 0.78A 1ikeA-5ojsT:
undetectable		 1ikeA-5ojsT:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ASN T3010
ASP T3004
LEU T3003
GLY T3002
PHE T3029
 None
 1.41A 1ju6A-5ojsT:
undetectable		 1ju6A-5ojsT:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ASN T3010
ASP T3004
LEU T3003
GLY T3002
PHE T3029
 None
 1.41A 1ju6C-5ojsT:
undetectable		 1ju6C-5ojsT:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ASN T3010
ASP T3004
LEU T3003
GLY T3002
PHE T3029
 None
 1.37A 1jujA-5ojsT:
undetectable		 1jujA-5ojsT:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ASN T3010
ASP T3004
LEU T3003
GLY T3002
PHE T3029
 None
 1.37A 1jujB-5ojsT:
undetectable		 1jujB-5ojsT:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ASN T3010
ASP T3004
LEU T3003
GLY T3002
PHE T3029
 None
 1.37A 1jujC-5ojsT:
undetectable		 1jujC-5ojsT:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ASN T3010
ASP T3004
LEU T3003
GLY T3002
PHE T3029
 None
 1.37A 1jujD-5ojsT:
undetectable		 1jujD-5ojsT:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T2853
LEU T2800
ALA T2915
ALA T2804
VAL T2813
 None
 1.05A 1kt4A-5ojsT:
undetectable		 1kt4A-5ojsT:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG T3439
ARG T2680
ARG T3438
 None
 1.05A 1l7fA-5ojsT:
undetectable		 1l7fA-5ojsT:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG T3439
ARG T2680
ARG T3438
 None
 1.05A 1l7hA-5ojsT:
undetectable		 1l7hA-5ojsT:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ASP T2198
GLU T2204
LEU T2210
LEU T2206
 None
 1.04A 1np1A-5ojsT:
undetectable		 1np1A-5ojsT:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE T3296
PHE T1129
LEU T3288
LEU T3321
LEU T3314
 None
 1.24A 1og5A-5ojsT:
undetectable		 1og5A-5ojsT:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE T3557
LEU T3645
GLY T3707
TYR T3560
 None
 1.03A 1rmtC-5ojsT:
undetectable		 1rmtC-5ojsT:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.06A 1rxcC-5ojsT:
undetectable		 1rxcC-5ojsT:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.00A 1rxcF-5ojsT:
undetectable		 1rxcF-5ojsT:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.04A 1rxcL-5ojsT:
undetectable		 1rxcL-5ojsT:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 ASP T  16
LEU T  55
LEU T  59
LEU T  54
 None
 1.31A 1u18A-5ojsT:
undetectable		 1u18A-5ojsT:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG T 817
ARG T 813
ILE T 863
 None
 0.83A 1uobA-5ojsT:
undetectable		 1uobA-5ojsT:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE T3641
PHE T3548
LEU T3467
SER T3559
 None
 0.70A 1wrlE-5ojsT:
undetectable		 1wrlE-5ojsT:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU T1219
SER T1227
LEU T1267
LEU T1237
 None
 0.86A 1yajA-5ojsT:
undetectable		 1yajA-5ojsT:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 SER T 818
LEU T 727
LEU T 765
LEU T 744
 None
 0.94A 2bfpD-5ojsT:
undetectable		 2bfpD-5ojsT:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T3171
LEU T3141
ILE T3137
ILE T3159
ALA T3160
 None
 1.00A 2bxqA-5ojsT:
undetectable		 2bxqA-5ojsT:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR T2859
ALA T2908
TYR T2916
ILE T2880
ILE T2877
 None
 1.33A 2dm6A-5ojsT:
undetectable
2dm6B-5ojsT:
undetectable		 2dm6A-5ojsT:
6.18
2dm6B-5ojsT:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 TYR T3388
ASP T3460
THR T3384
GLU T3469
 None
 1.40A 2dttB-5ojsT:
undetectable
2dttC-5ojsT:
undetectable		 2dttB-5ojsT:
2.79
2dttC-5ojsT:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ALA T3081
TYR T3085
ASN T3064
LEU T3107
 None
 0.91A 2hzqA-5ojsT:
undetectable		 2hzqA-5ojsT:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP T3112
GLU T3684
LEU T3688
HIS T3146
 None
 0.95A 2q0iA-5ojsT:
undetectable		 2q0iA-5ojsT:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU T2383
GLN T2418
ARG T2415
 None
 0.99A 2w3bB-5ojsT:
undetectable		 2w3bB-5ojsT:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER T1362
THR T1366
PHE T1338
 None
 0.70A 2x91A-5ojsT:
undetectable		 2x91A-5ojsT:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 THR T3647
VAL T3643
GLU T2672
ASP T2673
ASP T2894
 None
 1.19A 2xinA-5ojsT:
undetectable		 2xinA-5ojsT:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 THR T3647
VAL T3643
GLU T2672
ASP T2673
ASP T2894
 None
 1.11A 2xinB-5ojsT:
undetectable		 2xinB-5ojsT:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 THR T3647
VAL T3643
GLU T2672
ASP T2673
ASP T2894
 None
 1.15A 2xinC-5ojsT:
undetectable		 2xinC-5ojsT:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 THR T3647
VAL T3643
GLU T2672
ASP T2673
ASP T2894
 None
 1.10A 2xinD-5ojsT:
undetectable		 2xinD-5ojsT:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 THR T1667
GLN T1720
SER T1664
TYR T1712
 None
 1.23A 2xz5C-5ojsT:
undetectable
2xz5D-5ojsT:
undetectable		 2xz5C-5ojsT:
4.60
2xz5D-5ojsT:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T1672
THR T1675
PHE T1611
LEU T1636
ILE T1627
 None
 1.26A 2ydoA-5ojsT:
undetectable		 2ydoA-5ojsT:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLN T3718
PHE T3719
LEU T3645
PHE T3641
 None
 1.08A 3ablC-5ojsT:
undetectable
3ablJ-5ojsT:
undetectable		 3ablC-5ojsT:
5.12
3ablJ-5ojsT:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP T1098
SER T1016
LYS T1019
ASP T2543
 None
 1.33A 3bc9A-5ojsT:
undetectable		 3bc9A-5ojsT:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG T1618
VAL T1628
THR T1675
 None
 0.82A 3cyxA-5ojsT:
undetectable		 3cyxA-5ojsT:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 GLU T  98
LEU T  56
LEU T 100
LEU T 104
SER T 105
 None
 1.07A 3g2oA-5ojsT:
undetectable		 3g2oA-5ojsT:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA T1260
ILE T1216
LEU T1193
LEU T1214
GLY T1211
 None
 1.06A 3k2hB-5ojsT:
undetectable		 3k2hB-5ojsT:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL T2336
LEU T2333
LEU T2339
SER T2328
SER T2356
 None
 0.95A 3kk6A-5ojsT:
undetectable		 3kk6A-5ojsT:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL T2336
LEU T2333
LEU T2339
SER T2328
SER T2356
 None
 1.15A 3kk6B-5ojsT:
undetectable		 3kk6B-5ojsT:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR T3241
GLU T3243
LEU T3288
LEU T3287
ILE T3292
 None
 1.20A 3kvrA-5ojsT:
undetectable		 3kvrA-5ojsT:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 THR T3241
GLU T3243
LEU T3288
LEU T3287
ILE T3292
 None
 1.21A 3kvrB-5ojsT:
undetectable		 3kvrB-5ojsT:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.12A 3kvvB-5ojsT:
undetectable		 3kvvB-5ojsT:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.10A 3kvvE-5ojsT:
undetectable		 3kvvE-5ojsT:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.03A 3kvvF-5ojsT:
undetectable		 3kvvF-5ojsT:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE T3344
HIS T3340
SER T3228
LEU T1345
LEU T3224
 None
 1.29A 3lcvB-5ojsT:
undetectable		 3lcvB-5ojsT:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU T 705
PHE T 638
PHE T 736
PHE T 698
 None
 1.46A 3m0wB-5ojsT:
undetectable
3m0wJ-5ojsT:
undetectable		 3m0wB-5ojsT:
2.44
3m0wJ-5ojsT:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 VAL T1024
LEU T1027
ILE T2491
ALA T 976
 None
 0.93A 3n8yB-5ojsT:
undetectable		 3n8yB-5ojsT:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 THR T3241
GLU T3243
LEU T3288
LEU T3287
ILE T3292
 None
 1.15A 3nbqA-5ojsT:
undetectable		 3nbqA-5ojsT:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE T1110
ILE T1145
LEU T1106
SER T1032
HIS T1109
 None
 1.21A 3o1cA-5ojsT:
undetectable		 3o1cA-5ojsT:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE T1110
ILE T1145
LEU T1106
SER T1032
HIS T1109
 None
 1.23A 3o1xA-5ojsT:
undetectable		 3o1xA-5ojsT:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.23A 3p4wA-5ojsT:
undetectable		 3p4wA-5ojsT:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.22A 3p4wE-5ojsT:
undetectable		 3p4wE-5ojsT:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE T1110
ILE T1145
LEU T1106
SER T1032
HIS T1109
 None
 1.25A 3qgzA-5ojsT:
undetectable		 3qgzA-5ojsT:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 LEU T2263
LEU T2259
ILE T2217
ALA T2216
VAL T2209
 None
 0.89A 3r9cA-5ojsT:
undetectable		 3r9cA-5ojsT:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS T2091
SER T2005
ASN T  39
 None
 0.90A 3s8pB-5ojsT:
undetectable		 3s8pB-5ojsT:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE T3134
LEU T3105
SER T3143
LEU T3156
ILE T3137
 None
 1.02A 3tq9A-5ojsT:
undetectable		 3tq9A-5ojsT:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 PHE T 294
LYS T 214
SER T 216
 None
 1.31A 3tyeB-5ojsT:
undetectable		 3tyeB-5ojsT:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 VAL T2454
PHE T2579
SER T2609
ILE T2613
ILE T2583
 None
 1.32A 3um5A-5ojsT:
undetectable		 3um5A-5ojsT:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 VAL T2454
PHE T2579
SER T2609
ILE T2613
ILE T2583
 None
 1.36A 3um5B-5ojsT:
undetectable		 3um5B-5ojsT:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE T 776
LEU T 727
PRO T 734
GLU T 730
 None
 1.41A 3vlnA-5ojsT:
undetectable		 3vlnA-5ojsT:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU T 681
TYR T 685
SER T 592
 None
 0.84A 4at0A-5ojsT:
undetectable		 4at0A-5ojsT:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.04A 4e1vB-5ojsT:
undetectable		 4e1vB-5ojsT:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY T1681
ARG T1731
ILE T1678
VAL T1677
 None
 1.01A 4e1vF-5ojsT:
undetectable		 4e1vF-5ojsT:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ILE T2610
LEU T2451
SER T2570
PRO T2572
ILE T2613
 None
 1.25A 4g8zX-5ojsT:
undetectable		 4g8zX-5ojsT:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 SER T 942
LEU T 932
PHE T2846
PRO T 934
 None
 1.16A 4j7uD-5ojsT:
undetectable		 4j7uD-5ojsT:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 ILE T1556
PHE T1592
LEU T1538
ILE T1552
THR T1594
 None
 1.18A 4km0A-5ojsT:
undetectable		 4km0A-5ojsT:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ASN T1077
GLU T1084
GLU T 971
TYR T1207
 None
 1.23A 4mj8A-5ojsT:
undetectable
4mj8C-5ojsT:
undetectable		 4mj8A-5ojsT:
4.25
4mj8C-5ojsT:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU T2469
ASN T2470
LEU T2476
ILE T2546
 None
 1.11A 4okxA-5ojsT:
undetectable		 4okxA-5ojsT:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 SER T2611
ASP T2608
GLN T3537
 None
 0.95A 4oltA-5ojsT:
undetectable
4oltB-5ojsT:
undetectable		 4oltA-5ojsT:
5.22
4oltB-5ojsT:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 ALA T1148
ALA T1152
LEU T1200
SER T1143
LEU T1144
 None
 1.39A 4or0A-5ojsT:
undetectable		 4or0A-5ojsT:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T2973
GLY T2939
GLN T2924
GLN T2910
ILE T2943
 None
 1.29A 4p6xA-5ojsT:
undetectable		 4p6xA-5ojsT:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T2973
GLY T2939
GLN T2924
GLN T2910
ILE T2943
 None
 1.32A 4p6xE-5ojsT:
undetectable		 4p6xE-5ojsT:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T2973
GLY T2939
GLN T2924
GLN T2910
ILE T2943
 None
 1.26A 4p6xI-5ojsT:
undetectable		 4p6xI-5ojsT:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE T1782
GLN T1779
THR T1810
ILE T1807
 None
 1.08A 4pcuA-5ojsT:
undetectable		 4pcuA-5ojsT:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ASN T1287
VAL T1284
LEU T1311
LEU T1242
ASN T1239
 None
 1.24A 4qckA-5ojsT:
undetectable		 4qckA-5ojsT:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 THR T1271
ILE T1292
LEU T1241
ILE T1216
 None
 0.74A 4r38A-5ojsT:
undetectable		 4r38A-5ojsT:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 THR T3568
TRP T3743
THR T3257
ASN T3250
HIS T3570
 None
 1.29A 4s0vA-5ojsT:
undetectable		 4s0vA-5ojsT:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 GLU T2094
ARG T2102
LYS T2139
TYR T2142
 None
 1.21A 4uciB-5ojsT:
undetectable		 4uciB-5ojsT:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU T3140
LEU T3141
LEU T3156
ALA T3166
LEU T3167
 None
 0.84A 4wg0B-5ojsT:
undetectable
4wg0C-5ojsT:
undetectable
4wg0D-5ojsT:
undetectable		 4wg0B-5ojsT:
0.35
4wg0C-5ojsT:
0.35
4wg0D-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU T3140
LEU T3141
LEU T3156
ALA T3166
LEU T3167
 None
 0.85A 4wg0D-5ojsT:
undetectable
4wg0E-5ojsT:
undetectable
4wg0F-5ojsT:
undetectable		 4wg0D-5ojsT:
0.35
4wg0E-5ojsT:
0.35
4wg0F-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA T3166
LEU T3167
LEU T3156
LEU T3140
LEU T3141
 None
 0.80A 4wg0C-5ojsT:
undetectable
4wg0D-5ojsT:
undetectable
4wg0E-5ojsT:
undetectable		 4wg0C-5ojsT:
0.35
4wg0D-5ojsT:
0.35
4wg0E-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA T3166
LEU T3167
LEU T3156
LEU T3140
LEU T3141
 None
 0.80A 4wg0E-5ojsT:
undetectable
4wg0F-5ojsT:
undetectable
4wg0G-5ojsT:
undetectable		 4wg0E-5ojsT:
0.35
4wg0F-5ojsT:
0.35
4wg0G-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU T3140
LEU T3141
LEU T3156
ALA T3166
LEU T3167
 None
 0.86A 4wg0H-5ojsT:
undetectable
4wg0I-5ojsT:
undetectable
4wg0J-5ojsT:
undetectable		 4wg0H-5ojsT:
0.35
4wg0I-5ojsT:
0.35
4wg0J-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU T3140
LEU T3141
LEU T3156
ALA T3166
LEU T3167
 None
 0.86A 4wg0J-5ojsT:
undetectable
4wg0K-5ojsT:
undetectable
4wg0L-5ojsT:
undetectable		 4wg0J-5ojsT:
0.35
4wg0K-5ojsT:
0.35
4wg0L-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA T3166
LEU T3167
LEU T3156
LEU T3140
LEU T3141
 None
 0.86A 4wg0I-5ojsT:
undetectable
4wg0J-5ojsT:
undetectable
4wg0K-5ojsT:
undetectable		 4wg0I-5ojsT:
0.35
4wg0J-5ojsT:
0.35
4wg0K-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA T3166
LEU T3167
LEU T3156
LEU T3140
LEU T3141
 None
 0.85A 4wg0K-5ojsT:
undetectable
4wg0L-5ojsT:
undetectable
4wg0M-5ojsT:
undetectable		 4wg0K-5ojsT:
0.35
4wg0L-5ojsT:
0.35
4wg0M-5ojsT:
0.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 MET T3489
ASP T3737
PHE T3740
 None
 1.05A 4xeyA-5ojsT:
undetectable		 4xeyA-5ojsT:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU T3314
ARG T3315
ARG T3318
 None
 0.94A 4yiaB-5ojsT:
undetectable		 4yiaB-5ojsT:
1.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS T2589
ARG T2594
HIS T2592
 None
 1.22A 4zbrA-5ojsT:
undetectable		 4zbrA-5ojsT:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE T3544
LEU T3543
ASP T3540
THR T3577
ASP T 965
 None
 1.18A 5cg6A-5ojsT:
undetectable		 5cg6A-5ojsT:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS T2091
SER T2005
ASN T  39
 None
 0.88A 5cprB-5ojsT:
undetectable		 5cprB-5ojsT:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASN T 695
ALA T 696
ARG T1585
 None
 0.52A 5cvtB-5ojsT:
undetectable		 5cvtB-5ojsT:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU T1261
ASP T1258
VAL T1303
ALA T1306
 None
 1.42A 5dl9A-5ojsT:
undetectable		 5dl9A-5ojsT:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU T1638
ALA T1637
GLU T1641
ASN T1680
 None
 1.44A 5dwkC-5ojsT:
undetectable		 5dwkC-5ojsT:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU T3391
ILE T3393
PRO T3355
LEU T3229
 None
 1.16A 5eb3A-5ojsT:
undetectable		 5eb3A-5ojsT:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU T 744
LEU T 741
PHE T 736
LEU T 706
 None
 0.80A 5gs4A-5ojsT:
undetectable		 5gs4A-5ojsT:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ASP T1108
HIS T1109
GLY T2525
ALA T2528
 None
 0.90A 5hwaA-5ojsT:
undetectable		 5hwaA-5ojsT:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 ASN T3732
ILE T3720
TYR T3560
PHE T3555
 None
 1.38A 5igvA-5ojsT:
undetectable		 5igvA-5ojsT:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA T3549
ALA T3636
ILE T3632
LEU T3631
 None
 0.79A 5jncD-5ojsT:
undetectable		 5jncD-5ojsT:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 VAL T3047
LEU T3086
SER T3083
ILE T3104
 None
 0.94A 5jw1A-5ojsT:
undetectable		 5jw1A-5ojsT:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG T2445
ILE T 982
PHE T2480
 None
 0.75A 5kirA-5ojsT:
undetectable		 5kirA-5ojsT:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE T 363
TYR T 359
LEU T 367
PRO T 326
TYR T 321
 None
 1.21A 5ljcA-5ojsT:
undetectable		 5ljcA-5ojsT:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.15A 5mvnB-5ojsT:
undetectable		 5mvnB-5ojsT:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.15A 5mvnD-5ojsT:
undetectable		 5mvnD-5ojsT:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.26A 5mzrA-5ojsT:
undetectable		 5mzrA-5ojsT:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.26A 5mzrC-5ojsT:
undetectable		 5mzrC-5ojsT:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.27A 5mzrD-5ojsT:
undetectable		 5mzrD-5ojsT:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T2027
ALA T2032
ILE T2029
ALA T2028
ILE T2123
 None
 1.33A 5nm5B-5ojsT:
undetectable		 5nm5B-5ojsT:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU T1989
LEU T1931
TRP T1969
 None
 0.91A 5nwuA-5ojsT:
undetectable		 5nwuA-5ojsT:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS T2827
TRP T2828
SER T2830
 None
 1.39A 5nwwA-5ojsT:
undetectable		 5nwwA-5ojsT:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU T1153
ILE T1149
GLY T1215
LEU T1166
ALA T1167
 None
 0.95A 5o96A-5ojsT:
undetectable
5o96B-5ojsT:
undetectable		 5o96A-5ojsT:
5.15
5o96B-5ojsT:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 LEU T1153
ILE T1149
GLY T1215
LEU T1166
ALA T1167
 None
 1.02A 5o96C-5ojsT:
undetectable
5o96D-5ojsT:
undetectable		 5o96C-5ojsT:
5.15
5o96D-5ojsT:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 PRO T 326
LEU T 328
PHE T 324
LEU T 367
 None
 1.22A 5tl8A-5ojsT:
undetectable		 5tl8A-5ojsT:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 SER T2636
ILE T2639
LEU T2640
LEU T2665
 None
 0.97A 5u4sB-5ojsT:
undetectable		 5u4sB-5ojsT:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR T 418
ALA T 391
TYR T 392
 None
 0.84A 5uunB-5ojsT:
undetectable		 5uunB-5ojsT:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T1107
PHE T1087
ILE T1145
ILE T1216
GLY T1211
 None
 0.89A 5veuB-5ojsT:
undetectable		 5veuB-5ojsT:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU T1803
ALA T1786
LEU T1744
ASN T1741
ILE T1766
 None
 1.20A 5xiwD-5ojsT:
undetectable		 5xiwD-5ojsT:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR T 710
PRO T 707
LEU T 706
 None
 0.94A 6beoA-5ojsT:
undetectable		 6beoA-5ojsT:
0.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE T1770
VAL T1806
ALA T1786
THR T1787
 None
 0.85A 6cduC-5ojsT:
undetectable
6cduD-5ojsT:
undetectable		 6cduC-5ojsT:
6.75
6cduD-5ojsT:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 TRP T2729
ILE T2690
THR T2686
TYR T2685
 None
 1.05A 6cduG-5ojsT:
undetectable
6cduH-5ojsT:
undetectable		 6cduG-5ojsT:
6.75
6cduH-5ojsT:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ASP T2552
PHE T2549
ILE T2548
LEU T2545
MET T2605
 None
 1.32A 6fgcA-5ojsT:
undetectable		 6fgcA-5ojsT:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS T 353
ARG T 311
ILE T 310
 None
 0.79A 6fgdA-5ojsT:
undetectable		 6fgdA-5ojsT:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU T1596
VAL T1607
LEU T1620
LEU T1636
 None
 0.74A 6g9bA-5ojsT:
undetectable
6g9bB-5ojsT:
undetectable		 6g9bA-5ojsT:
2.21
6g9bB-5ojsT:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 ILE T 141
ILE T 143
GLU T 226
ILE T 144
MET T  97
 None
 1.24A 6hloA-5ojsT:
undetectable		 6hloA-5ojsT:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ILE T 485
THR T 484
PRO T 579
 None
 0.64A 6ncsA-5ojsT:
undetectable		 6ncsA-5ojsT:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 GLN T1726
PHE T1725
LEU T1703
PHE T1752
 None
 1.23A 6nmpC-5ojsT:
undetectable
6nmpJ-5ojsT:
undetectable		 6nmpC-5ojsT:
5.12
6nmpJ-5ojsT:
1.71