SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ok4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		4 / 8 ALA A 329
PHE A 336
THR A 334
ASP A 321
 None
 1.27A 2kotB-5ok4A:
undetectable		 2kotB-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 11 VAL A  59
GLY A  47
ILE A  37
LEU A 123
THR A  40
 None
 1.36A 3bexC-5ok4A:
undetectable
3bexD-5ok4A:
undetectable		 3bexC-5ok4A:
undetectable
3bexD-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 10 LEU A 123
THR A  40
VAL A  59
GLY A  47
ILE A  37
 None
 1.37A 3bexC-5ok4A:
undetectable
3bexD-5ok4A:
undetectable		 3bexC-5ok4A:
undetectable
3bexD-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 10 VAL A  59
GLY A  47
ILE A  37
LEU A 123
THR A  40
 None
 1.37A 3bexE-5ok4A:
undetectable
3bexF-5ok4A:
undetectable		 3bexE-5ok4A:
undetectable
3bexF-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 11 LEU A 123
THR A  40
VAL A  59
GLY A  47
ILE A  37
 None
 1.37A 3bexE-5ok4A:
undetectable
3bexF-5ok4A:
undetectable		 3bexE-5ok4A:
undetectable
3bexF-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 11 VAL A  59
GLY A  47
ILE A  37
LEU A 123
THR A  40
 None
 1.38A 3bf1A-5ok4A:
undetectable
3bf1B-5ok4A:
undetectable		 3bf1A-5ok4A:
undetectable
3bf1B-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 11 VAL A  59
GLY A  47
ILE A  37
LEU A 123
THR A  40
 None
 1.40A 3bf1C-5ok4A:
undetectable
3bf1D-5ok4A:
undetectable		 3bf1C-5ok4A:
undetectable
3bf1D-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 11 LEU A 123
THR A  40
VAL A  59
GLY A  47
ILE A  37
 None
 1.41A 3bf1C-5ok4A:
undetectable
3bf1D-5ok4A:
undetectable		 3bf1C-5ok4A:
undetectable
3bf1D-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 11 VAL A  59
GLY A  47
ILE A  37
LEU A 123
THR A  40
 None
 1.38A 3bf1E-5ok4A:
undetectable
3bf1F-5ok4A:
undetectable		 3bf1E-5ok4A:
undetectable
3bf1F-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 11 LEU A 123
THR A  40
VAL A  59
GLY A  47
ILE A  37
 None
 1.39A 3bf1E-5ok4A:
undetectable
3bf1F-5ok4A:
undetectable		 3bf1E-5ok4A:
undetectable
3bf1F-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		4 / 6 PHE A 145
HIS A 170
THR A 169
VAL A 168
 FEG  A 404 (-4.9A)
None
None
None
 1.23A 3lb3A-5ok4A:
undetectable		 3lb3A-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		4 / 6 THR A  45
GLY A  47
ILE A   5
LEU A 123
 None
 1.21A 4ac9C-5ok4A:
2.9		 4ac9C-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		4 / 6 THR A  45
GLY A  47
ILE A   5
LEU A 123
 None
 1.21A 4acaC-5ok4A:
undetectable		 4acaC-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		3 / 3 PRO A 108
LEU A 107
HIS A 116
 None
 0.64A 4pevA-5ok4A:
2.9		 4pevA-5ok4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 12 TYR A 202
GLY A 233
GLU A 231
LEU A 243
HIS A 203
 None
None
None
None
FE  A 401 ( 3.2A)
 1.24A 4wcxC-5ok4A:
undetectable		 4wcxC-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU A 123
THR A  40
VAL A  59
GLY A  47
ILE A  37
 None
 1.27A 5b8hA-5ok4A:
undetectable
5b8hB-5ok4A:
undetectable		 5b8hA-5ok4A:
undetectable
5b8hB-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 12 PHE A 117
ILE A  73
PHE A  22
THR A  45
ALA A  84
 None
 1.20A 5vcgA-5ok4A:
undetectable		 5vcgA-5ok4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 12 ALA A  62
GLU A 121
TYR A 202
VAL A  59
ASP A 122
 FEG  A 404 (-4.2A)
None
None
None
None
 1.38A 5vlmC-5ok4A:
undetectable		 5vlmC-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 12 PRO A  35
ALA A  29
GLU A 121
VAL A  72
PHE A  70
 None
 1.26A 5x6yA-5ok4A:
undetectable		 5x6yA-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 12 PHE A  70
ILE A 127
VAL A  65
PHE A  66
HIS A  41
 None
None
FEG  A 404 ( 4.9A)
None
None
 1.08A 6ap6A-5ok4A:
undetectable		 6ap6A-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE
(Methanothermobac
ter
marburgensis) 		5 / 12 PHE A  70
ILE A 127
VAL A  65
PHE A  66
HIS A  41
 None
None
FEG  A 404 ( 4.9A)
None
None
 1.07A 6ap6B-5ok4A:
undetectable		 6ap6B-5ok4A:
undetectable