SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		4 / 8 VAL C 208
ASN C 236
GLY C 169
LEU C 180
 None
 0.91A 1dzmA-5okiC:
undetectable		 1dzmA-5okiC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		4 / 5 GLY C 175
PRO C 123
VAL C 122
ILE C 144
 None
 1.01A 2aoiA-5okiC:
undetectable		 2aoiA-5okiC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 494
VAL A 261
TRP A  78
 None
 0.80A 2cc8A-5okiA:
undetectable		 2cc8A-5okiA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 494
VAL A 261
TRP A  78
 None
 0.81A 2ccbA-5okiA:
undetectable		 2ccbA-5okiA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		4 / 5 LEU C 185
ILE C 230
SER C 171
GLY C 170
 None
 1.01A 2otfA-5okiC:
undetectable		 2otfA-5okiC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 494
VAL A 261
TRP A  78
 None
 0.79A 2vx9A-5okiA:
undetectable		 2vx9A-5okiA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 332
PHE C 333
ARG C 368
THR C 375
 None
 1.00A 3ag4N-5okiC:
undetectable
3ag4W-5okiC:
undetectable		 3ag4N-5okiC:
undetectable
3ag4W-5okiC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 4 PRO A 137
TYR A 135
GLY A 116
THR A  85
 None
 1.22A 3ib0A-5okiA:
undetectable		 3ib0A-5okiA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 121
TYR A 265
VAL A 117
PHE A 272
 None
 1.24A 3ltwA-5okiA:
undetectable		 3ltwA-5okiA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 234
ILE C 231
ILE C 254
HIS C 190
VAL C 215
 None
 1.02A 4a97B-5okiC:
undetectable
4a97C-5okiC:
undetectable		 4a97B-5okiC:
13.42
4a97C-5okiC:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 120
MET A  82
ILE A 500
 None
 0.90A 4c8bB-5okiA:
undetectable		 4c8bB-5okiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 496
CYH A 497
PRO A 491
ASP A 421
MET A 420
 None
 1.15A 4j7xF-5okiA:
undetectable		 4j7xF-5okiA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		5 / 9 VAL C 143
GLY C 175
PRO C 123
VAL C 122
ILE C 144
 None
 1.19A 4ll3B-5okiC:
undetectable		 4ll3B-5okiC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 468
LEU A 321
THR A 323
THR A 481
 None
 1.14A 4mbsA-5okiA:
undetectable		 4mbsA-5okiA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 193
LEU C 201
VAL C 215
ALA C 214
ILE C 231
 None
 1.17A 4x1kD-5okiC:
undetectable		 4x1kD-5okiC:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 515
GLY A 511
ILE A 493
MET A 420
THR A 507
 None
 1.46A 4x3mA-5okiA:
undetectable		 4x3mA-5okiA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 121
ASP A 123
PHE A 129
VAL A 267
 None
 1.14A 5a1rA-5okiA:
undetectable		 5a1rA-5okiA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5oki SISTER CHROMATID
COHESION PROTEIN
DCC1
(Saccharomyces
cerevisiae) 		3 / 3 THR C 104
HIS C  65
ASN C  67
 None
 0.97A 5n4tA-5okiC:
undetectable		 5n4tA-5okiC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 431
PRO A 433
LEU A 432
 None
 0.91A 6beoA-5okiA:
undetectable		 6beoA-5okiA:
undetectable