SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5okl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5okl AFAMIN
(Homo
sapiens) 		5 / 9 TYR A  33
GLY A 251
PHE A  30
GLN A  32
ILE A  77
 None
 1.06A 1oltA-5oklA:
undetectable		 1oltA-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5okl AFAMIN
(Homo
sapiens) 		5 / 12 LEU A 426
LEU A 411
GLY A 430
ARG A 524
ILE A 417
 None
 1.47A 1p93A-5oklA:
undetectable		 1p93A-5oklA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5okl AFAMIN
(Homo
sapiens) 		3 / 3 SER A 242
HIS A 201
ASP A 451
 None
 0.72A 2oxtA-5oklA:
undetectable		 2oxtA-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5okl AFAMIN
(Homo
sapiens) 		4 / 6 ILE A 219
SER A 223
ARG A 339
ARG A 340
 None
 0.99A 2q72A-5oklA:
undetectable		 2q72A-5oklA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5okl AFAMIN
(Homo
sapiens) 		4 / 7 PRO A  84
GLY A  82
LEU A  45
PHE A  30
 None
 1.04A 2vl2B-5oklA:
undetectable		 2vl2B-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 5okl AFAMIN
(Homo
sapiens) 		4 / 5 LYS A  53
ASP A  54
ARG A  55
GLU A  51
 None
 1.35A 2x8oA-5oklA:
undetectable		 2x8oA-5oklA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5okl AFAMIN
(Homo
sapiens) 		5 / 12 LEU A 388
PHE A 447
ALA A 448
ILE A 346
ALA A 220
 None
 1.03A 3nxuA-5oklA:
undetectable		 3nxuA-5oklA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5okl AFAMIN
(Homo
sapiens) 		5 / 12 LEU A 388
PHE A 447
ALA A 448
ILE A 346
ALA A 220
 None
 1.06A 3nxuB-5oklA:
undetectable		 3nxuB-5oklA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5okl AFAMIN
(Homo
sapiens) 		5 / 9 PRO A 419
TYR A 498
VAL A 534
THR A 415
ILE A 412
 None
 1.21A 3p4wB-5oklA:
3.6		 3p4wB-5oklA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 5okl AFAMIN
(Homo
sapiens) 		4 / 6 GLU A 239
ASP A 240
ASP A 259
LYS A 262
 None
 1.27A 3pocB-5oklA:
undetectable		 3pocB-5oklA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5okl AFAMIN
(Homo
sapiens) 		5 / 12 LEU A 530
LEU A 414
GLY A 405
LEU A 406
PHE A 437
 None
 1.34A 3tbgA-5oklA:
3.2		 3tbgA-5oklA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5okl AFAMIN
(Homo
sapiens) 		4 / 4 ILE A  22
ASN A  21
ILE A 257
VAL A 254
 None
 1.30A 4uy87-5oklA:
undetectable		 4uy87-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5okl AFAMIN
(Homo
sapiens) 		4 / 6 LEU A 349
SER A 223
PRO A 227
PHE A 226
 None
 1.19A 5b8iA-5oklA:
undetectable		 5b8iA-5oklA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 5okl AFAMIN
(Homo
sapiens) 		3 / 3 GLU A 144
ARG A 147
TYR A 143
 None
 0.62A 5trqB-5oklA:
undetectable		 5trqB-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5okl AFAMIN
(Homo
sapiens) 		4 / 6 ASN A 554
ALA A 553
PRO A 574
VAL A 555
 None
 1.16A 5umd2-5oklA:
undetectable
5umdF-5oklA:
undetectable		 5umd2-5oklA:
21.43
5umdF-5oklA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5okl AFAMIN
(Homo
sapiens) 		4 / 8 ASP A 455
ARG A 486
GLU A 460
ARG A 524
 None
 1.26A 6fbvD-5oklA:
undetectable		 6fbvD-5oklA:
undetectable