SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.47A 1d4fA-5okoA:
undetectable
1d4fA-5okoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.44A 1d4fB-5okoA:
undetectable
1d4fB-5okoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.48A 1d4fD-5okoA:
undetectable
1d4fD-5okoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 PHE A 557
GLY A 545
LEU A 583
PHE A 605
None
0.92A 1gsfA-5okoA:
undetectable
1gsfA-5okoA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 PHE A 557
GLY A 545
LEU A 583
PHE A 605
None
0.92A 1gsfB-5okoA:
undetectable
1gsfB-5okoA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 PHE A 557
GLY A 545
LEU A 583
PHE A 605
None
0.92A 1gsfD-5okoA:
undetectable
1gsfD-5okoA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 GLY A 542
HIS A 561
THR A 532
ILE A 579
None
0.90A 1gtnF-5okoA:
undetectable
1gtnG-5okoA:
undetectable
1gtnF-5okoA:
11.36
1gtnG-5okoA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 SER A 716
VAL A 436
SER A 435
ASN A 507
None
1.17A 1hwiB-5okoA:
undetectable
1hwiB-5okoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 SER A 716
VAL A 436
SER A 435
ASN A 507
None
1.22A 1hwkA-5okoA:
undetectable
1hwkA-5okoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 SER A 716
VAL A 436
SER A 435
ASN A 507
None
1.23A 1hwkC-5okoA:
undetectable
1hwkC-5okoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 SER A 716
VAL A 436
SER A 435
ASN A 507
None
1.23A 1hwkD-5okoA:
undetectable
1hwkD-5okoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 LEU A 637
GLY A 606
TYR A 610
GLU A 652
None
1.07A 1jlfA-5okoA:
undetectable
1jlfB-5okoA:
undetectable
1jlfA-5okoA:
22.65
1jlfB-5okoA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 GLU A 642
ARG A 691
LEU A 639
ASP A 635
None
1.24A 1n13B-5okoA:
undetectable
1n13C-5okoA:
undetectable
1n13B-5okoA:
13.00
1n13C-5okoA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 TRP A 688
THR A 660
TYR A 663
LEU A 451
None
1.47A 1uw6A-5okoA:
undetectable
1uw6B-5okoA:
undetectable
1uw6A-5okoA:
23.04
1uw6B-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 TRP A 688
THR A 660
TYR A 671
LEU A 451
None
1.12A 1uw6A-5okoA:
undetectable
1uw6B-5okoA:
undetectable
1uw6A-5okoA:
23.04
1uw6B-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 TRP A 688
THR A 660
TYR A 671
LEU A 451
None
1.14A 1uw6D-5okoA:
undetectable
1uw6E-5okoA:
undetectable
1uw6D-5okoA:
23.04
1uw6E-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 TRP A 688
THR A 660
TYR A 663
LEU A 451
None
1.48A 1uw6G-5okoA:
undetectable
1uw6H-5okoA:
undetectable
1uw6G-5okoA:
23.04
1uw6H-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 TRP A 688
THR A 660
TYR A 671
LEU A 451
None
1.13A 1uw6G-5okoA:
undetectable
1uw6H-5okoA:
undetectable
1uw6G-5okoA:
23.04
1uw6H-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 TRP A 688
THR A 660
TYR A 671
LEU A 451
None
1.14A 1uw6P-5okoA:
undetectable
1uw6Q-5okoA:
undetectable
1uw6P-5okoA:
23.04
1uw6Q-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 LEU A 451
TRP A 688
THR A 660
TYR A 663
None
1.44A 1uw6P-5okoA:
undetectable
1uw6T-5okoA:
undetectable
1uw6P-5okoA:
23.04
1uw6T-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 LEU A 451
TRP A 688
THR A 660
TYR A 671
None
1.10A 1uw6P-5okoA:
undetectable
1uw6T-5okoA:
undetectable
1uw6P-5okoA:
23.04
1uw6T-5okoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.24A 2eikN-5okoA:
undetectable
2eikP-5okoA:
undetectable
2eikN-5okoA:
22.94
2eikP-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 6 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.26A 2eimN-5okoA:
undetectable
2eimP-5okoA:
undetectable
2eimN-5okoA:
22.94
2eimP-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 PHE A 603
PHE A 557
PHE A 548
VAL A 727
None
1.13A 2lh6A-5okoA:
undetectable
2lh6A-5okoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 LEU A 803
PHE A 766
PHE A 769
ILE A 753
None
0.96A 2opxA-5okoA:
undetectable
2opxA-5okoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.24A 3abmN-5okoA:
undetectable
3abmP-5okoA:
undetectable
3abmN-5okoA:
22.94
3abmP-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.40A 3g1uA-5okoA:
undetectable
3g1uA-5okoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.42A 3g1uC-5okoA:
undetectable
3g1uC-5okoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.42A 3glqA-5okoA:
undetectable
3glqA-5okoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.38A 3glqB-5okoA:
undetectable
3glqB-5okoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.41A 3n58D-5okoA:
undetectable
3n58D-5okoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 10 PHE A 555
PHE A 603
VAL A 468
PHE A 557
ILE A 522
None
1.47A 3t3qA-5okoA:
undetectable
3t3qA-5okoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 10 PHE A 555
PHE A 603
VAL A 468
PHE A 557
ILE A 522
None
1.43A 3t3qB-5okoA:
undetectable
3t3qB-5okoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 10 PHE A 555
PHE A 603
VAL A 468
PHE A 557
ILE A 522
None
1.45A 3t3qC-5okoA:
undetectable
3t3qC-5okoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 10 PHE A 555
PHE A 603
VAL A 468
PHE A 557
ILE A 522
None
1.45A 3t3qD-5okoA:
undetectable
3t3qD-5okoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 11 LEU A 856
THR A 863
VAL A 757
GLU A 836
PHE A 766
None
1.40A 3tbgA-5okoA:
undetectable
3tbgA-5okoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 TRP A 688
THR A 660
TYR A 671
LEU A 451
None
1.04A 3wipG-5okoA:
undetectable
3wipH-5okoA:
undetectable
3wipG-5okoA:
23.29
3wipH-5okoA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 LEU A 451
TRP A 688
THR A 660
TYR A 671
None
1.05A 3wipF-5okoA:
undetectable
3wipJ-5okoA:
undetectable
3wipF-5okoA:
23.29
3wipJ-5okoA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 HIS A 718
SER A 716
SER A 435
VAL A 436
None
1.20A 4a99D-5okoA:
undetectable
4a99D-5okoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 HIS A 858
GLU A 836
ALA A 755
SER A 596
ASP A 594
None
1.32A 4aqlA-5okoA:
undetectable
4aqlA-5okoA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 SER A 716
PHE A 605
GLY A 606
ALA A 543
VAL A 544
None
1.18A 4dx5B-5okoA:
undetectable
4dx5B-5okoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 SER A 687
TYR A 661
ARG A 662
VAL A 685
None
1.18A 4l64A-5okoA:
undetectable
4l64A-5okoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 LEU A 803
SER A 780
ILE A 767
VAL A 825
None
1.03A 4tvtA-5okoA:
undetectable
4tvtA-5okoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 SER A 716
PHE A 605
GLY A 606
ALA A 543
VAL A 544
None
1.15A 4u95B-5okoA:
undetectable
4u95B-5okoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 631
LEU A 612
ILE A 619
LEU A 620
ILE A 616
None
1.03A 4y0rA-5okoA:
undetectable
4y0rA-5okoA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.25A 5b1aN-5okoA:
undetectable
5b1aP-5okoA:
undetectable
5b1aN-5okoA:
22.94
5b1aP-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 GLY A 556
ILE A 595
LEU A 583
GLY A 586
GLY A 552
None
None
None
EDO  A 904 (-3.5A)
None
1.14A 5d4uA-5okoA:
undetectable
5d4uA-5okoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 GLY A 556
ILE A 595
LEU A 583
GLY A 586
GLY A 552
None
None
None
EDO  A 904 (-3.5A)
None
1.12A 5d4uB-5okoA:
undetectable
5d4uB-5okoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 TYR A 707
GLY A 723
THR A 724
GLY A 860
None
0.93A 5jlcA-5okoA:
undetectable
5jlcA-5okoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 THR A 430
ASP A 478
VAL A 546
GLY A 545
None
0.79A 5nzyA-5okoA:
undetectable
5nzyA-5okoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.28A 5vooA-5okoA:
undetectable
5vooA-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.26A 5vooB-5okoA:
undetectable
5vooB-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.28A 5vooC-5okoA:
undetectable
5vooC-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.27A 5vooD-5okoA:
undetectable
5vooD-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 5 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.30A 5vooE-5okoA:
undetectable
5vooE-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 4 ASP A 607
ASN A 432
ASP A 717
ASN A 684
None
1.27A 5vooF-5okoA:
undetectable
5vooF-5okoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 6 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.26A 5x1bN-5okoA:
undetectable
5x1bP-5okoA:
undetectable
5x1bN-5okoA:
22.94
5x1bP-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.28A 5x1fN-5okoA:
undetectable
5x1fP-5okoA:
undetectable
5x1fN-5okoA:
22.94
5x1fP-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 7 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.27A 5zcqN-5okoA:
undetectable
5zcqP-5okoA:
undetectable
5zcqN-5okoA:
22.94
5zcqP-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
3 / 3 VAL A 514
TYR A 497
GLU A 519
None
0.99A 5zmqD-5okoA:
undetectable
5zmqE-5okoA:
undetectable
5zmqD-5okoA:
18.48
5zmqE-5okoA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
5 / 12 LEU A 823
LEU A 774
LEU A 806
MET A 870
PHE A 852
None
1.48A 6gbnC-5okoA:
undetectable
6gbnC-5okoA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 8 ASP A 587
HIS A 858
GLU A 836
GLU A 768
None
1.21A 6mn4A-5okoA:
undetectable
6mn4A-5okoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 6 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.25A 6nknA-5okoA:
undetectable
6nknC-5okoA:
undetectable
6nknA-5okoA:
22.94
6nknC-5okoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo
sapiens)
4 / 6 HIS A 674
ASP A 669
THR A 670
TYR A 671
None
1.24A 6nmpA-5okoA:
undetectable
6nmpC-5okoA:
undetectable
6nmpA-5okoA:
22.94
6nmpC-5okoA:
19.78