SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5okz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 ALA H 117
VAL H 119
TRP H 124
 None
 0.87A 1av2A-5okzH:
undetectable
1av2B-5okzH:
undetectable		 1av2A-5okzH:
5.08
1av2B-5okzH:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.84A 1av2C-5okzH:
undetectable
1av2D-5okzH:
undetectable		 1av2C-5okzH:
5.08
1av2D-5okzH:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5okz EXOSOME COMPLEX
COMPONENT MTR3
(Saccharomyces
cerevisiae) 		4 / 6 ALA F  60
LEU F  61
ILE F  74
SER F 175
 None
 1.03A 1sbrA-5okzF:
undetectable
1sbrB-5okzF:
undetectable		 1sbrA-5okzF:
23.02
1sbrB-5okzF:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 ALA H 117
VAL H 119
TRP H 124
 None
 0.82A 1w5uA-5okzH:
undetectable
1w5uB-5okzH:
undetectable		 1w5uA-5okzH:
5.08
1w5uB-5okzH:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.78A 1w5uA-5okzH:
undetectable
1w5uB-5okzH:
undetectable		 1w5uA-5okzH:
5.08
1w5uB-5okzH:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5okz EXOSOME COMPLEX
COMPONENT MTR3
(Saccharomyces
cerevisiae) 		4 / 7 ARG F  81
SER F  94
PHE F 138
GLN F  96
 None
 1.15A 2c8aA-5okzF:
undetectable		 2c8aA-5okzF:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 194
LEU H 169
ARG H 187
SER H 140
 None
 1.05A 2hc4A-5okzH:
undetectable		 2hc4A-5okzH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5okz EXOSOME COMPLEX
COMPONENT MTR3
(Saccharomyces
cerevisiae) 		4 / 5 ILE F 173
PRO F 170
PHE F 116
VAL F 201
 None
 1.35A 2hjhB-5okzF:
undetectable		 2hjhB-5okzF:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 ALA H 117
VAL H 119
TRP H 124
 None
 0.83A 2izqA-5okzH:
undetectable
2izqB-5okzH:
undetectable		 2izqA-5okzH:
5.08
2izqB-5okzH:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.77A 2izqC-5okzH:
undetectable
2izqD-5okzH:
undetectable		 2izqC-5okzH:
5.08
2izqD-5okzH:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5okz EXOSOME COMPLEX
COMPONENT MTR3
(Saccharomyces
cerevisiae) 		5 / 10 ILE F  53
ALA F 179
LEU F  73
ILE F  74
PHE F  52
 None
 1.10A 2w9sD-5okzF:
undetectable		 2w9sD-5okzF:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		4 / 6 SER H 343
VAL H 328
TYR H 329
ASP H 347
 None
 1.28A 2x45A-5okzH:
undetectable		 2x45A-5okzH:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		5 / 12 ILE H 128
GLY H 129
GLY H 229
PHE H 199
ARG H 115
 None
None
None
None
CL  H 401 (-3.9A)
 1.01A 2y7kC-5okzH:
undetectable		 2y7kC-5okzH:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5okz EXOSOME COMPLEX
COMPONENT MTR3
(Saccharomyces
cerevisiae) 		4 / 7 LEU F  48
ARG F 236
GLY F 192
MET F 190
 None
 1.07A 3hcrB-5okzF:
undetectable		 3hcrB-5okzF:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5okz EXOSOME COMPLEX
COMPONENT MTR3
(Saccharomyces
cerevisiae) 		5 / 10 LEU F 127
ILE F 135
PRO F  80
SER F  82
GLY F 134
 None
 1.37A 3ijxB-5okzF:
undetectable
3ijxD-5okzF:
undetectable		 3ijxB-5okzF:
20.96
3ijxD-5okzF:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.93A 3l8lA-5okzH:
undetectable
3l8lB-5okzH:
undetectable		 3l8lA-5okzH:
5.08
3l8lB-5okzH:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		3 / 3 TRP H 124
ALA H 117
VAL H 119
 None
 0.83A 3l8lC-5okzH:
undetectable
3l8lD-5okzH:
undetectable		 3l8lC-5okzH:
5.08
3l8lD-5okzH:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		5 / 10 ASN H 228
VAL H 227
VAL H 113
TYR H 191
GLY H 226
 None
 1.48A 3lp1A-5okzH:
undetectable		 3lp1A-5okzH:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5okz EXOSOME COMPLEX
COMPONENT RRP4
(Saccharomyces
cerevisiae) 		5 / 9 ALA H 308
GLY H 345
ILE H 344
ILE H 319
ILE H 314
 None
 1.04A 3s45A-5okzH:
undetectable		 3s45A-5okzH:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5okz EXOSOME COMPLEX
COMPONENT MTR3
(Saccharomyces
cerevisiae) 		3 / 3 LYS F 163
GLU F 109
TRP F 214
 None
 1.37A 3v4tH-5okzF:
undetectable		 3v4tH-5okzF:
21.53