SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ol0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 6 LEU A  62
GLU A  68
ASP A  69
PRO A  70
 None
 0.96A 1ditH-5ol0A:
undetectable
1ditP-5ol0A:
undetectable		 1ditH-5ol0A:
16.13
1ditP-5ol0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 12 LEU A 342
LEU A 111
LEU A 112
MET A 240
ILE A 215
 None
 1.05A 1g50B-5ol0A:
undetectable		 1g50B-5ol0A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 11 LEU A 342
LEU A 111
LEU A 112
MET A 240
ILE A 215
 None
 1.06A 1g50C-5ol0A:
undetectable		 1g50C-5ol0A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 6 ALA A  40
SER A  43
ASN A 125
ILE A 126
ASP A 127
 None
 0.23A 1yc2A-5ol0A:
20.7		 1yc2A-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 6 SER A  43
PHE A  51
ILE A 126
ASP A 127
 None
 0.74A 1yc2A-5ol0A:
20.7		 1yc2A-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 5 ALA A  40
ASN A 125
ILE A 126
ASP A 127
 None
 0.26A 1yc2D-5ol0A:
23.3		 1yc2D-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 7 ILE A  48
ASN A 125
ILE A 126
ASP A 127
 None
 0.21A 1yc2E-5ol0A:
21.1		 1yc2E-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 7 ILE A  48
PHE A  51
ILE A 126
ASP A 127
 None
 0.88A 1yc2E-5ol0A:
21.1		 1yc2E-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		6 / 7 ALA A  40
SER A  43
ILE A  48
ASN A 125
ILE A 126
ASP A 127
 None
 0.28A 1yc5A-5ol0A:
9.4		 1yc5A-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 5 ALA A  40
ILE A  48
ASN A 125
ILE A 126
ASP A 127
 None
 0.37A 2h4jA-5ol0A:
21.7		 2h4jA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 5 ILE A  48
PRO A  49
PHE A  51
ILE A 126
 None
 0.70A 2hjhA-5ol0A:
28.0		 2hjhA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 12 LEU A  95
PHE A 147
ILE A  89
SER A  43
VAL A  38
 None
 1.23A 2hrcA-5ol0A:
undetectable		 2hrcA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 5 LEU A  19
LEU A 342
LEU A 111
MET A 240
 None
 1.14A 2oaxF-5ol0A:
undetectable		 2oaxF-5ol0A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		3 / 3 LEU A 118
ARG A 120
ILE A  34
 None
 0.68A 2xn5B-5ol0A:
undetectable		 2xn5B-5ol0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 8 ALA A  46
HIS A 106
GLY A  47
ILE A  48
 None
 0.84A 2zm9A-5ol0A:
undetectable		 2zm9A-5ol0A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 11 LEU A  95
PHE A 147
ILE A  89
SER A  43
VAL A  38
 None
 1.21A 3aqiA-5ol0A:
undetectable		 3aqiA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 8 ALA A 150
ILE A 161
ASN A 164
PRO A  97
 None
 0.97A 3fxrA-5ol0A:
undetectable		 3fxrA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 4 PRO A 102
THR A 103
GLY A 216
THR A 217
 None
 1.09A 3ib1A-5ol0A:
undetectable		 3ib1A-5ol0A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 4 PRO A 236
LEU A 211
ILE A  34
ARG A 117
 None
 1.46A 3w1wA-5ol0A:
undetectable		 3w1wA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 4 ASN A 125
ALA A  40
GLY A  39
THR A 217
 None
 1.13A 4bboC-5ol0A:
undetectable		 4bboC-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 9 ILE A  26
LEU A 211
VAL A 238
VAL A  13
LEU A  14
 None
 1.12A 4g1bC-5ol0A:
4.1		 4g1bC-5ol0A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 5 PHE A  74
HIS A 144
LEU A 194
PRO A 223
 None
 0.95A 4o8zA-5ol0A:
31.1		 4o8zA-5ol0A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 7 ILE A  48
ASN A 125
ILE A 126
ASP A 127
 None
 0.27A 4rmjA-5ol0A:
33.9		 4rmjA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 7 VAL A 231
MET A 219
ARG A 332
ILE A 215
 None
 0.73A 4uxqA-5ol0A:
undetectable		 4uxqA-5ol0A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		4 / 8 LEU A 129
GLU A 142
LEU A 140
HIS A 107
 None
 1.26A 5dxeA-5ol0A:
undetectable		 5dxeA-5ol0A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 12 ALA A 150
PHE A 147
ALA A 149
ILE A  89
LEU A  79
 None
 0.96A 6a5zL-5ol0A:
undetectable		 6a5zL-5ol0A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2
(Leishmania
infantum) 		5 / 12 LEU A  93
ILE A 126
HIS A 144
ALA A  73
TYR A  87
 None
 0.99A 6djzA-5ol0A:
undetectable		 6djzA-5ol0A:
undetectable