SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ol2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
4 / 4 HIS A 280
LEU A 251
LEU A 225
LEU A 317
FAD  A 401 (-3.7A)
None
None
None
1.16A 1a4lD-5ol2A:
undetectable
1a4lD-5ol2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
5 / 12 GLY B  46
VAL B 160
ILE B 118
THR B 153
ILE B 151
None
0.83A 1c6zA-5ol2B:
undetectable
1c6zA-5ol2B:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
5 / 12 GLY B  46
VAL B 160
ILE B 118
THR B 153
ILE B 151
None
0.81A 1c6zB-5ol2B:
undetectable
1c6zB-5ol2B:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 8 ILE C 245
ASN C 158
GLY C 241
LEU C 238
None
None
None
COS  C 402 (-4.4A)
0.87A 1dzmA-5ol2C:
undetectable
1dzmA-5ol2C:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 GLY C 244
VAL C 298
ALA C  88
GLY C 251
SER C  76
None
1.10A 1kiaA-5ol2C:
undetectable
1kiaA-5ol2C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 5 GLU B 206
THR B  65
LEU B  89
LEU B  88
None
1.09A 1u18B-5ol2B:
undetectable
1u18B-5ol2B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 10 GLY C  51
HIS C  89
ALA C  71
THR C  90
ILE C  52
None
1.36A 1utdQ-5ol2C:
undetectable
1utdR-5ol2C:
undetectable
1utdQ-5ol2C:
11.38
1utdR-5ol2C:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 6 ASP B  98
SER A 109
LEU A 116
GLY A 115
FAD  B 300 (-3.9A)
None
None
None
0.93A 2j2pA-5ol2B:
undetectable
2j2pC-5ol2B:
undetectable
2j2pA-5ol2B:
23.51
2j2pC-5ol2B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 6 ASP B  98
SER A 109
LEU A 116
GLY A 115
FAD  B 300 (-3.9A)
None
None
None
0.91A 2j2pD-5ol2B:
undetectable
2j2pF-5ol2B:
undetectable
2j2pD-5ol2B:
23.51
2j2pF-5ol2B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
6 / 12 ARG A 107
GLY B 121
ALA B 120
ILE B  64
ILE B 117
ILE B 136
None
FAD  B 300 (-3.2A)
FAD  B 300 (-3.0A)
None
None
None
1.47A 2nmyA-5ol2A:
undetectable
2nmyA-5ol2A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
4 / 7 ILE A 246
ARG A 243
PRO A 266
GLY A 283
None
FAD  A 401 (-3.6A)
None
None
1.24A 2pnjB-5ol2A:
2.1
2pnjB-5ol2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT
ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile;
Clostridioides
difficile)
5 / 12 GLY B 194
ILE C  52
ALA C 114
ASP C  64
GLU B 201
None
1.27A 2vdvE-5ol2B:
undetectable
2vdvE-5ol2B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT
ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile;
Clostridioides
difficile)
5 / 11 GLY B 194
ILE C  52
ALA C 114
ASP C  64
GLU B 201
None
1.26A 2vdvF-5ol2B:
undetectable
2vdvF-5ol2B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 7 TYR C   8
TYR C  15
ILE C  52
ASP C  64
None
1.21A 2x45B-5ol2C:
undetectable
2x45B-5ol2C:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 7 TYR C   8
TYR C  15
ILE C  52
ASP C  64
None
1.21A 2x45C-5ol2C:
undetectable
2x45C-5ol2C:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 7 LEU B 140
ILE B 118
ALA B  74
ILE B  39
None
0.80A 2xkwA-5ol2B:
undetectable
2xkwA-5ol2B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 7 GLY A 115
HIS B 139
HIS A 113
TRP B 100
None
1.13A 3ai8A-5ol2A:
undetectable
3ai8A-5ol2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
3 / 3 LEU B 142
VAL B 132
ARG A 107
None
FAD  B 300 (-3.8A)
None
0.89A 3b0wB-5ol2B:
undetectable
3b0wB-5ol2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
3 / 3 THR C  28
GLU C 349
HIS C 337
None
0.83A 3g1uB-5ol2C:
undetectable
3g1uB-5ol2C:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 8 GLY B 253
ILE A 270
CYH A 272
PHE A 302
None
0.88A 3ko0B-5ol2B:
undetectable
3ko0J-5ol2B:
undetectable
3ko0B-5ol2B:
18.60
3ko0J-5ol2B:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 8 GLY B 253
ILE A 270
CYH A 272
PHE A 302
None
0.95A 3ko0K-5ol2B:
undetectable
3ko0S-5ol2B:
undetectable
3ko0K-5ol2B:
18.60
3ko0S-5ol2B:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
4 / 7 GLU A  28
VAL A 125
VAL A   4
ALA A  30
None
1.05A 3kp6B-5ol2A:
undetectable
3kp6B-5ol2A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 8 TYR C  68
VAL C  72
GLY C 244
GLY C  83
None
0.77A 3n9jB-5ol2C:
undetectable
3n9jB-5ol2C:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
6 / 11 ARG A 107
GLY B 121
ALA B 120
ILE B  64
ILE B 117
ILE B 136
None
FAD  B 300 (-3.2A)
FAD  B 300 (-3.0A)
None
None
None
1.37A 3ndxB-5ol2A:
undetectable
3ndxB-5ol2A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 TYR C  68
VAL C  84
ALA C  88
SER C  91
LEU C  92
None
1.09A 3pghD-5ol2C:
undetectable
3pghD-5ol2C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
3 / 3 PHE B 164
CYH B 167
HIS B 169
None
1.10A 3u9fF-5ol2B:
undetectable
3u9fF-5ol2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
3 / 3 PHE B 164
CYH B 167
HIS B 169
None
1.07A 3u9fG-5ol2B:
undetectable
3u9fG-5ol2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
3 / 3 PHE B 164
CYH B 167
HIS B 169
None
1.08A 3u9fL-5ol2B:
undetectable
3u9fL-5ol2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
3 / 3 PHE B 164
CYH B 167
HIS B 169
None
1.04A 3u9fS-5ol2B:
undetectable
3u9fS-5ol2B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 7 SER C 134
GLY C 130
THR C 131
PHE C 231
COS  C 402 (-3.2A)
FAD  C 401 (-3.3A)
FAD  C 401 ( 3.2A)
COS  C 402 (-4.6A)
0.95A 4ac9C-5ol2C:
undetectable
4ac9C-5ol2C:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 TYR C  68
VAL C  84
ALA C  88
SER C  91
LEU C  92
None
1.10A 4coxA-5ol2C:
undetectable
4coxA-5ol2C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 TYR C  68
VAL C  84
ALA C  88
SER C  91
LEU C  92
None
1.08A 4coxB-5ol2C:
undetectable
4coxB-5ol2C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 TYR C  68
VAL C  84
ALA C  88
SER C  91
LEU C  92
None
1.09A 4coxC-5ol2C:
undetectable
4coxC-5ol2C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 TYR C  68
VAL C  84
ALA C  88
SER C  91
LEU C  92
None
1.08A 4coxD-5ol2C:
undetectable
4coxD-5ol2C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 7 TYR B 147
ARG B 162
THR A  98
ILE A 100
None
0.94A 4eq4A-5ol2B:
undetectable
4eq4A-5ol2B:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 7 TYR B 147
ARG B 162
THR A  98
ILE A 100
None
0.96A 4eqlB-5ol2B:
undetectable
4eqlB-5ol2B:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile;
Clostridioides
difficile)
4 / 4 ASP A 103
LEU A 104
ARG A 111
THR B 146
None
None
CA  A 402 ( 4.0A)
None
1.40A 4kjjA-5ol2A:
undetectable
4kjjA-5ol2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile;
Clostridioides
difficile)
4 / 4 ASP A 103
LEU A 104
ARG A 111
THR B 146
None
None
CA  A 402 ( 4.0A)
None
1.42A 4kjkA-5ol2A:
2.1
4kjkA-5ol2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
4 / 8 GLY A  96
ILE A   8
LEU A  23
LEU A  20
None
0.81A 4mwzB-5ol2A:
undetectable
4mwzB-5ol2A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
6 / 11 GLY B  46
VAL B 160
ILE B 145
ILE B 118
THR B 153
ILE B 151
None
1.10A 4njvC-5ol2B:
undetectable
4njvC-5ol2B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
5 / 12 LEU B  89
ASN B 112
ILE B 113
GLY B 108
ALA B 107
None
1.03A 4nkvA-5ol2B:
undetectable
4nkvA-5ol2B:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
5 / 12 LEU B  89
ASN B 112
ILE B 113
GLY B 108
ALA B 107
None
1.02A 4nkvC-5ol2B:
undetectable
4nkvC-5ol2B:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
5 / 12 LEU B  89
ASN B 112
ILE B 113
GLY B 108
ALA B 107
None
1.01A 4nkvD-5ol2B:
undetectable
4nkvD-5ol2B:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 6 MET C  44
MET C  50
LEU C 119
ILE C 160
None
1.13A 4okxA-5ol2C:
undetectable
4okxA-5ol2C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile;
Clostridioides
difficile)
4 / 5 ASP A 103
LEU A 104
ARG A 111
THR B 146
None
None
CA  A 402 ( 4.0A)
None
1.33A 4p3qA-5ol2A:
undetectable
4p3qA-5ol2A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 7 GLY C 255
ALA C 256
GLU C 259
THR C 260
None
0.87A 4r1zB-5ol2C:
undetectable
4r1zB-5ol2C:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 GLY C  83
ALA C 114
MET C  50
TYR C  68
TYR C  54
None
1.19A 4r29B-5ol2C:
3.1
4r29B-5ol2C:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 GLY C  93
ALA C  88
ILE C  97
VAL C 166
ILE C 184
None
1.13A 4uw0A-5ol2C:
undetectable
4uw0A-5ol2C:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 8 ARG C 350
ALA C  27
LEU C  30
GLY C 205
None
0.86A 4xk8a-5ol2C:
2.3
4xk8a-5ol2C:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT
ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile;
Clostridioides
difficile)
4 / 5 THR C  65
GLY C  67
GLU B 201
ASP C 306
None
1.18A 5c0oH-5ol2C:
undetectable
5c0oH-5ol2C:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5ol2 ACYL-COA
DEHYDROGENASE
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 6 SER C   5
ASP B 198
GLY C  63
GLU C  61
None
0.95A 5cdqA-5ol2C:
2.8
5cdqC-5ol2C:
2.7
5cdqD-5ol2C:
undetectable
5cdqA-5ol2C:
21.53
5cdqC-5ol2C:
21.53
5cdqD-5ol2C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
3 / 3 THR C 157
ALA C  88
ASN C 158
FAD  C 401 (-3.7A)
None
None
0.40A 5ersA-5ol2C:
undetectable
5ersA-5ol2C:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 6 PHE A 184
GLU A  83
GLU B 138
VAL A 108
None
1.16A 5h4dA-5ol2A:
2.5
5h4dA-5ol2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 ILE C 245
TYR C 361
GLY C 240
GLY C  83
VAL C  72
None
1.09A 5i71A-5ol2C:
undetectable
5i71A-5ol2C:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
3 / 3 VAL A  18
LEU A 132
MET A 134
None
0.87A 5ikrA-5ol2A:
undetectable
5ikrA-5ol2A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 8 TYR C 165
LYS C 187
THR C 157
ILE C  85
None
None
FAD  C 401 (-3.7A)
None
1.02A 5jhdE-5ol2C:
undetectable
5jhdG-5ol2C:
undetectable
5jhdE-5ol2C:
20.73
5jhdG-5ol2C:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
4 / 5 TYR A 229
SER A 214
ALA A 215
THR A 245
None
1.08A 5n0wB-5ol2A:
2.9
5n0wB-5ol2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
4 / 5 TYR A 229
SER A 214
ALA A 215
THR A 245
None
0.99A 5n4iA-5ol2A:
2.2
5n4iA-5ol2A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
4 / 6 LYS B  52
VAL B 158
LYS B 152
ILE B 179
None
1.32A 5q1sA-5ol2B:
undetectable
5q1sA-5ol2B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
4 / 8 THR C 189
PRO C 190
ILE C 218
PRO C 219
None
0.97A 6a4iA-5ol2C:
1.8
6a4iA-5ol2C:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile)
4 / 7 ILE A   8
VAL A   6
ALA A  26
THR A  27
None
0.74A 6cduC-5ol2A:
undetectable
6cduD-5ol2A:
undetectable
6cduC-5ol2A:
22.40
6cduD-5ol2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 10 GLU C  61
GLY C  60
GLY C  59
ALA C 114
GLY C  48
None
1.07A 6e5zA-5ol2C:
undetectable
6e5zA-5ol2C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile;
Clostridioides
difficile)
5 / 11 THR A 158
PHE A  95
ALA A  81
THR A  78
ALA B 137
None
1.18A 6efnA-5ol2A:
undetectable
6efnA-5ol2A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile)
5 / 12 ARG A 265
GLU B  20
ASP B  17
ASN A 142
ASP B 128
None
1.25A 6ekuA-5ol2A:
undetectable
6ekuA-5ol2A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile)
5 / 12 THR C 157
LEU C  92
VAL C 166
THR C  81
GLY C  80
FAD  C 401 (-3.7A)
None
None
None
None
1.15A 6gngA-5ol2C:
undetectable
6gngA-5ol2C:
20.96