SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ol6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIJ_A_NOVA400_1 (DNA GYRASE SUBUNIT B)	5ol6	NUCLEIC ACID BINDING, OB-FOLD, TRNA/HELICASE-TYPE,D NA-DIRECTED DNA POLYMERASE (Nostoc punctiforme)	5 / 12	ASP A 120 ILE A 129 PRO A 125 ASP A 113 THR A 118	None	1.23A	1kijA-5ol6A: undetectable	1kijA-5ol6A: 15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZM8_A_ACAA512_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	5ol6	NUCLEIC ACID BINDING, OB-FOLD, TRNA/HELICASE-TYPE,D NA-DIRECTED DNA POLYMERASE (Nostoc punctiforme)	5 / 10	ALA A 36 PHE A 116 HIS A 114 GLY A 19 ILE A 18	None	1.39A	2zm8A-5ol6A: undetectable	2zm8A-5ol6A: 17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ME6_A_CGEA501_1 (CYTOCHROME P450 2B4)	5ol6	NUCLEIC ACID BINDING, OB-FOLD, TRNA/HELICASE-TYPE,D NA-DIRECTED DNA POLYMERASE (Nostoc punctiforme)	5 / 10	VAL A 75 ILE A 33 ALA A 36 ILE A 50 VAL A 72	None	1.07A	3me6A-5ol6A: undetectable	3me6A-5ol6A: 15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SMT_A_ACTA1001_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD3)	5ol6	NUCLEIC ACID BINDING, OB-FOLD, TRNA/HELICASE-TYPE,D NA-DIRECTED DNA POLYMERASE (Nostoc punctiforme)	4 / 5	LEU A 102 GLY A 105 PHE A 32 ARG A 138	None	1.19A	3smtA-5ol6A: undetectable	3smtA-5ol6A: 15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA501_1 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	5ol6	NUCLEIC ACID BINDING, OB-FOLD, TRNA/HELICASE-TYPE,D NA-DIRECTED DNA POLYMERASE (Nostoc punctiforme)	5 / 12	THR A 48 VAL A 20 ASP A 17 ILE A 18 ARG A 92	None	1.23A	4i41A-5ol6A: undetectable	4i41A-5ol6A: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW8_B_FK5B201_1 (FK506-BINDING PROTEIN 1)	5ol6	NUCLEIC ACID BINDING, OB-FOLD, TRNA/HELICASE-TYPE,D NA-DIRECTED DNA POLYMERASE (Nostoc punctiforme)	5 / 11	ASP A 17 ARG A 92 ILE A 63 ILE A 60 ILE A 50	None	1.17A	5hw8B-5ol6A: undetectable	5hw8B-5ol6A: 21.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KIJ_A_NOVA400_1","DNA GYRASE SUBUNIT B","5ol6","NUCLEIC ACID BINDING, OB-FOLD, TRNA\/HELICASE-TYPE,DNA-DIRECTED DNA POLYMERASE","Nostoc punctiforme",5,"ASP A 120;ILE A 129;PRO A 125;ASP A 113;THR A 118","None","1.23A","1kijA-5ol6A:undetectable","1kijA-5ol6A:15.74"],["2ZM8_A_ACAA512_1","6-AMINOHEXANOATE-DIMER HYDROLASE","5ol6","NUCLEIC ACID BINDING, OB-FOLD, TRNA\/HELICASE-TYPE,DNA-DIRECTED DNA POLYMERASE","Nostoc punctiforme",5,"ALA A  36;PHE A 116;HIS A 114;GLY A  19;ILE A  18","None","1.39A","2zm8A-5ol6A:undetectable","2zm8A-5ol6A:17.82"],["3ME6_A_CGEA501_1","CYTOCHROME P450 2B4","5ol6","NUCLEIC ACID BINDING, OB-FOLD, TRNA\/HELICASE-TYPE,DNA-DIRECTED DNA POLYMERASE","Nostoc punctiforme",5,"VAL A  75;ILE A  33;ALA A  36;ILE A  50;VAL A  72","None","1.07A","3me6A-5ol6A:undetectable","3me6A-5ol6A:15.76"],["3SMT_A_ACTA1001_0","HISTONE-LYSINE N-METHYLTRANSFERASE SETD3","5ol6","NUCLEIC ACID BINDING, OB-FOLD, TRNA\/HELICASE-TYPE,DNA-DIRECTED DNA POLYMERASE","Nostoc punctiforme",4,"LEU A 102;GLY A 105;PHE A  32;ARG A 138","None","1.19A","3smtA-5ol6A:undetectable","3smtA-5ol6A:15.40"],["4I41_A_MIXA501_1","SERINE\/THREONINE-PROTEIN KINASE PIM-1","5ol6","NUCLEIC ACID BINDING, OB-FOLD, TRNA\/HELICASE-TYPE,DNA-DIRECTED DNA POLYMERASE","Nostoc punctiforme",5,"THR A  48;VAL A  20;ASP A  17;ILE A  18;ARG A  92","None","1.23A","4i41A-5ol6A:undetectable","4i41A-5ol6A:20.07"],["5HW8_B_FK5B201_1","FK506-BINDING PROTEIN 1","5ol6","NUCLEIC ACID BINDING, OB-FOLD, TRNA\/HELICASE-TYPE,DNA-DIRECTED DNA POLYMERASE","Nostoc punctiforme",5,"ASP A  17;ARG A  92;ILE A  63;ILE A  60;ILE A  50","None","1.17A","5hw8B-5ol6A:undetectable","5hw8B-5ol6A:21.68"]]