SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ol8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 352
ILE A 348
ARG A 293
 None
 0.82A 1cd2A-5ol8A:
undetectable		 1cd2A-5ol8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TRP A 182
VAL A 174
TRP A 194
 None
 1.26A 1gmkC-5ol8A:
undetectable
1gmkD-5ol8A:
undetectable		 1gmkC-5ol8A:
3.07
1gmkD-5ol8A:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 172
PHE A 350
ALA A 354
LEU A 164
 None
 1.12A 2bxkA-5ol8A:
undetectable		 2bxkA-5ol8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A 285
ARG A 293
ALA A 347
ASP A 342
 None
 1.16A 2e5dA-5ol8A:
undetectable
2e5dB-5ol8A:
undetectable		 2e5dA-5ol8A:
21.77
2e5dB-5ol8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 342
PHE A 285
ARG A 293
ALA A 347
 None
 1.18A 2e5dA-5ol8A:
undetectable
2e5dB-5ol8A:
undetectable		 2e5dA-5ol8A:
21.77
2e5dB-5ol8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 229
ILE A 171
ILE A 173
ILE A 219
 None
 0.85A 3p4wC-5ol8A:
undetectable		 3p4wC-5ol8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 THR A 190
PRO A 318
ASP A 320
 None
 0.86A 5l8dB-5ol8A:
undetectable		 5l8dB-5ol8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 LEU A 189
ALA A 347
SER A 172
GLN A 302
ARG A 293
GLY A 296
 None
 1.49A 5m5cB-5ol8A:
undetectable		 5m5cB-5ol8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR A 229
ILE A 171
ILE A 173
ILE A 219
 None
 0.87A 5murB-5ol8A:
undetectable		 5murB-5ol8A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 THR A 190
PRO A 318
ASP A 320
 None
 0.86A 5mwuB-5ol8A:
undetectable		 5mwuB-5ol8A:
19.62