SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5olc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 7 THR A 333
THR A 297
GLY A 299
TYR A  49
 None
 0.91A 1bu5A-5olcA:
undetectable		 1bu5A-5olcA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 8 THR A 333
THR A 297
GLY A 299
TYR A  49
 None
 0.88A 1bu5B-5olcA:
undetectable		 1bu5B-5olcA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 ARG A 233
TYR A 201
ASP A 227
VAL A 223
PRO A 222
 None
 1.30A 1ituB-5olcA:
2.1		 1ituB-5olcA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 5 ASP A 174
LEU A 191
ALA A 211
LEU A 207
 None
 1.00A 1nh8A-5olcA:
undetectable		 1nh8A-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		3 / 3 ASP A 339
THR A 342
GLU A  47
 None
 0.51A 1pj7A-5olcA:
2.1		 1pj7A-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 ALA A 273
GLY A 275
LEU A 276
ASP A 269
PRO A 268
 None
 1.10A 2f8lA-5olcA:
undetectable		 2f8lA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 6 TYR A 289
LEU A 257
LYS A 232
ASP A 229
 None
 1.45A 2w98A-5olcA:
undetectable
2w98B-5olcA:
undetectable		 2w98A-5olcA:
11.14
2w98B-5olcA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 7 GLN A  95
ILE A 282
SER A  91
TYR A 252
 None
 1.35A 2xz5D-5olcA:
undetectable
2xz5E-5olcA:
undetectable		 2xz5D-5olcA:
undetectable
2xz5E-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 GLY A 275
LEU A 310
ASP A 102
ILE A  98
LEU A 250
 None
 0.92A 3cjtC-5olcA:
2.2		 3cjtC-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		3 / 3 ARG A 190
GLU A 220
ASP A 269
 None
 0.81A 3g2oA-5olcA:
undetectable		 3g2oA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 11 TYR A  43
THR A  37
ALA A 104
ILE A 108
GLU A  47
 None
 1.14A 3qelA-5olcA:
2.2
3qelB-5olcA:
2.2		 3qelA-5olcA:
13.07
3qelB-5olcA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 7 GLU A 220
GLU A 248
PHE A 254
PRO A 268
 None
 1.21A 3ql6A-5olcA:
undetectable		 3ql6A-5olcA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		3 / 3 ARG A 332
THR A 300
TRP A 301
 None
 1.19A 4d7hA-5olcA:
undetectable		 4d7hA-5olcA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 11 ILE A  36
ALA A 104
GLY A  46
GLU A  47
GLY A 274
 None
 1.24A 4e47B-5olcA:
undetectable		 4e47B-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 5 ILE A  33
ASP A 102
GLU A  47
VAL A 363
 None
 1.19A 4nkxC-5olcA:
undetectable		 4nkxC-5olcA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		4 / 5 ILE A  33
ASP A 102
GLU A  47
VAL A 363
 None
 1.17A 4nkxD-5olcA:
undetectable		 4nkxD-5olcA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 10 TYR A  43
THR A  37
ALA A 104
ILE A 108
GLU A  47
 None
 1.13A 4pe5A-5olcA:
2.1
4pe5B-5olcA:
2.2		 4pe5A-5olcA:
8.05
4pe5B-5olcA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 10 TYR A  43
THR A  37
ALA A 104
ILE A 108
GLU A  47
 None
 1.12A 4pe5C-5olcA:
1.3
4pe5D-5olcA:
1.9		 4pe5C-5olcA:
8.05
4pe5D-5olcA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		3 / 3 ARG A 332
THR A 300
TRP A 301
 None
 1.18A 4uglA-5olcA:
undetectable		 4uglA-5olcA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 11 TYR A  43
THR A  37
ALA A 104
ILE A 108
GLU A  47
 None
 1.20A 5ewjA-5olcA:
2.2
5ewjB-5olcA:
2.0		 5ewjA-5olcA:
13.07
5ewjB-5olcA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 TYR A  43
THR A  37
ALA A 104
ILE A 108
GLU A  47
 None
 1.19A 5ewjC-5olcA:
undetectable
5ewjD-5olcA:
2.2		 5ewjC-5olcA:
13.07
5ewjD-5olcA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		3 / 3 ARG A 332
THR A 300
TRP A 301
 None
 1.25A 5g6cA-5olcA:
undetectable		 5g6cA-5olcA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 ILE A 265
ALA A 306
ALA A 307
VAL A 311
GLY A 275
 None
 0.74A 5igjA-5olcA:
undetectable		 5igjA-5olcA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 ILE A 265
ALA A 306
ALA A 307
VAL A 311
GLY A 275
 None
 0.75A 5igpA-5olcA:
undetectable		 5igpA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 MET A 165
ALA A 180
LEU A 191
ILE A 216
TYR A 199
 None
 1.49A 5vlmA-5olcA:
undetectable		 5vlmA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5olc GALACTONATE
DEHYDRATASE
(Zobellia
galactanivorans) 		5 / 12 GLY A 299
ILE A  59
GLY A  46
ALA A  96
ALA A  97
 None
 1.00A 6c2mD-5olcA:
undetectable		 6c2mD-5olcA:
23.66