SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5olk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		3 / 3 PHE A 107
TRP A 319
GLU A 318
 None
 0.86A 1mogA-5olkA:
undetectable		 1mogA-5olkA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 8 TYR A  91
ARG A  95
TYR A  94
GLU A  76
 DTP  A1002 ( 3.6A)
None
DTP  A1002 (-3.5A)
None
 1.26A 1nx9A-5olkA:
undetectable		 1nx9A-5olkA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 8 TYR A  91
ARG A  95
TYR A  94
GLU A  76
 DTP  A1002 ( 3.6A)
None
DTP  A1002 (-3.5A)
None
 1.26A 1nx9B-5olkA:
undetectable		 1nx9B-5olkA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 8 TYR A  91
ARG A  95
TYR A  94
GLU A  76
 DTP  A1002 ( 3.6A)
None
DTP  A1002 (-3.5A)
None
 1.25A 1nx9C-5olkA:
undetectable		 1nx9C-5olkA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 8 TYR A  91
ARG A  95
TYR A  94
GLU A  76
 DTP  A1002 ( 3.6A)
None
DTP  A1002 (-3.5A)
None
 1.25A 1nx9D-5olkA:
undetectable		 1nx9D-5olkA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 ILE A 274
LEU A 151
SER A 142
LEU A 214
ILE A 287
 None
 0.98A 1rb3B-5olkA:
undetectable		 1rb3B-5olkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 11 GLU A 200
HIS A 203
GLU A 263
PHE A 271
GLU A 298
 MN  A1005 ( 2.1A)
MN  A1005 (-3.6A)
MN  A1004 (-2.1A)
None
MN  A1004 ( 2.4A)
 0.84A 1rnrA-5olkA:
31.1		 1rnrA-5olkA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 GLU A 200
HIS A 203
GLU A 263
PHE A 271
GLU A 298
 MN  A1005 ( 2.1A)
MN  A1005 (-3.6A)
MN  A1004 (-2.1A)
None
MN  A1004 ( 2.4A)
 0.89A 1rnrB-5olkA:
31.4		 1rnrB-5olkA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 GLU A 200
HIS A 203
TYR A 207
GLU A 263
GLU A 298
 MN  A1005 ( 2.1A)
MN  A1005 (-3.6A)
None
MN  A1004 (-2.1A)
MN  A1004 ( 2.4A)
 0.97A 1rnrB-5olkA:
31.4		 1rnrB-5olkA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 PHE A 176
GLY A 178
ILE A 189
THR A 195
GLU A 297
 None
 1.25A 1sg9A-5olkA:
3.3		 1sg9A-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		3 / 3 ARG A  98
SER A  15
TYR A  14
 DTP  A1002 (-4.6A)
None
None
 0.63A 1x70A-5olkA:
undetectable		 1x70A-5olkA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 11 GLU A 390
VAL A 359
ILE A 360
ILE A 274
PHE A 347
 None
 1.10A 2dg9A-5olkA:
undetectable		 2dg9A-5olkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 ILE A 169
PHE A 196
ILE A 128
ILE A 300
THR A 294
 None
 1.15A 2rlcA-5olkA:
undetectable		 2rlcA-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 9 GLY A 305
VAL A 306
ASP A 303
ILE A 300
VAL A 192
 None
 1.41A 3fhjD-5olkA:
undetectable		 3fhjD-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 9 GLY A 305
VAL A 306
ASP A 303
ILE A 300
VAL A 192
 None
 1.41A 3fhjF-5olkA:
undetectable		 3fhjF-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 9 GLY A 305
VAL A 306
ASP A 303
ILE A 300
VAL A 192
 None
 1.41A 3fi0H-5olkA:
undetectable		 3fi0H-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 10 ILE A 106
TYR A 251
THR A 252
ILE A 255
ILE A 309
 None
 1.16A 3p4wD-5olkA:
undetectable		 3p4wD-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 10 ILE A 106
TYR A 251
THR A 252
ILE A 255
ILE A 309
 None
 1.15A 3p4wE-5olkA:
2.3		 3p4wE-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 7 ILE A 106
TYR A 251
THR A 252
ILE A 255
 None
 0.85A 3p50A-5olkA:
2.3		 3p50A-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 7 ILE A 106
TYR A 251
THR A 252
ILE A 255
 None
 0.85A 3p50B-5olkA:
2.3		 3p50B-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 7 ILE A 106
TYR A 251
THR A 252
ILE A 255
 None
 0.84A 3p50C-5olkA:
2.3		 3p50C-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 7 ILE A 106
TYR A 251
THR A 252
ILE A 255
 None
 0.86A 3p50D-5olkA:
2.3		 3p50D-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 7 ILE A 106
TYR A 251
THR A 252
ILE A 255
 None
 0.86A 3p50E-5olkA:
undetectable		 3p50E-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		3 / 3 HIS A 209
SER A 167
ASN A 217
 None
 0.69A 3s8pB-5olkA:
undetectable		 3s8pB-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 11 ILE A 311
ILE A 308
GLY A 305
PHE A 304
GLY A 193
 None
 1.09A 4ac9B-5olkA:
undetectable
4ac9C-5olkA:
undetectable		 4ac9B-5olkA:
undetectable
4ac9C-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 LEU A 214
GLU A 219
LEU A 164
ILE A 287
ILE A 274
 None
 1.16A 4j24B-5olkA:
undetectable		 4j24B-5olkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 ASN A 278
MET A 283
ILE A 159
PHE A 140
LEU A 210
 None
 1.39A 4kosA-5olkA:
0.5		 4kosA-5olkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 ASN A 278
MET A 283
ILE A 159
PHE A 140
LEU A 210
 None
 1.30A 4kovA-5olkA:
undetectable		 4kovA-5olkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 PHE A 107
ILE A 312
GLU A 250
ASP A 247
SER A 245
 None
 1.41A 4r88A-5olkA:
undetectable		 4r88A-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 PHE A 107
ILE A 312
GLU A 250
ASP A 247
SER A 245
 None
 1.38A 4r88B-5olkA:
undetectable		 4r88B-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 PHE A 107
ILE A 312
GLU A 250
ASP A 247
SER A 245
 None
 1.38A 4r88C-5olkA:
undetectable		 4r88C-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 PHE A 107
ILE A 312
GLU A 250
ASP A 247
SER A 245
 None
 1.34A 4r88D-5olkA:
undetectable		 4r88D-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 PHE A 107
ILE A 312
GLU A 250
ASP A 247
SER A 245
 None
 1.39A 4r88E-5olkA:
undetectable		 4r88E-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 PHE A 107
ILE A 312
GLU A 250
ASP A 247
SER A 245
 None
 1.40A 4r88F-5olkA:
undetectable		 4r88F-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		4 / 7 ASN A 369
LYS A 365
TYR A 235
LEU A 257
 None
 1.15A 4yv5A-5olkA:
0.4		 4yv5A-5olkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		3 / 3 HIS A 209
SER A 167
ASN A 217
 None
 0.66A 5cprB-5olkA:
undetectable		 5cprB-5olkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1
(Leeuwenhoekiella
blandensis) 		5 / 12 SER A 371
SER A 239
THR A 238
LEU A 364
VAL A 265
 None
 0.97A 6a93B-5olkA:
undetectable		 6a93B-5olkA:
undetectable