SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ols'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A 281
LEU A 318
GLY A 269
ARG A 317
 None
GTR  A 608 (-4.6A)
None
None
 1.02A 1j7kA-5olsA:
undetectable		 1j7kA-5olsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A 281
LEU A 318
GLY A 279
ARG A 317
 None
GTR  A 608 (-4.6A)
None
None
 1.03A 1j7kA-5olsA:
undetectable		 1j7kA-5olsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
 None
None
None
ADA  A 604 ( 3.9A)
 1.27A 1nx9A-5olsA:
undetectable		 1nx9A-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
 None
None
None
ADA  A 604 ( 3.9A)
 1.27A 1nx9B-5olsA:
undetectable		 1nx9B-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
 None
None
None
ADA  A 604 ( 3.9A)
 1.26A 1nx9C-5olsA:
undetectable		 1nx9C-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 184
ARG A 160
GLU A 157
HIS A 153
 None
None
None
ADA  A 604 ( 3.9A)
 1.27A 1nx9D-5olsA:
undetectable		 1nx9D-5olsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 317
ASN A 339
SER A 340
ARG A 319
 None
None
None
GTR  A 608 (-3.0A)
 1.35A 1u1jA-5olsA:
undetectable		 1u1jA-5olsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 283
PHE A 266
TYR A 315
SER A 340
ASP A 215
 None
None
None
None
CA  A 601 (-2.1A)
 1.43A 2avdA-5olsA:
undetectable		 2avdA-5olsA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A  26
TYR A  27
PRO A  43
THR A  39
 None
 1.29A 2q6kA-5olsA:
undetectable		 2q6kA-5olsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 319
ASP A 215
ASN A 324
 GTR  A 608 (-3.0A)
CA  A 601 (-2.1A)
RAM  A 607 (-2.8A)
 0.78A 2zzmA-5olsA:
undetectable		 2zzmA-5olsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 182
ASP A 197
TRP A 242
ARG A 240
 None
 0.82A 3arrA-5olsA:
undetectable		 3arrA-5olsA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 182
ASP A 197
TRP A 242
ARG A 240
 None
 0.86A 3aruA-5olsA:
undetectable		 3aruA-5olsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 CYH A 158
PHE A 129
PHE A 159
 None
 0.82A 3cr5X-5olsA:
undetectable		 3cr5X-5olsA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A 347
GLY A 362
ASN A 386
ILE A 330
GLY A 287
 None
 1.19A 3eeyD-5olsA:
undetectable		 3eeyD-5olsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 246
GLY A 269
TYR A 270
TYR A 322
ASN A 324
 CA  A 602 (-2.5A)
None
None
GTR  A 608 (-4.9A)
RAM  A 607 (-2.8A)
 1.43A 3hiiA-5olsA:
undetectable		 3hiiA-5olsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 174
ASP A 177
ASP A 142
 None
 0.76A 3jayA-5olsA:
undetectable		 3jayA-5olsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 174
ASP A 177
ASP A 142
 None
 0.83A 3jb2A-5olsA:
undetectable		 3jb2A-5olsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 174
ASP A 177
ASP A 142
 None
 0.87A 3jb3A-5olsA:
undetectable		 3jb3A-5olsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A 324
ASP A 280
ARG A 125
 RAM  A 607 (-2.8A)
CA  A 602 ( 3.2A)
ADA  A 604 ( 3.0A)
 0.87A 3k13A-5olsA:
undetectable		 3k13A-5olsA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 170
PHE A 159
GLY A 188
PHE A 141
 None
 1.13A 3ko0K-5olsA:
undetectable
3ko0S-5olsA:
undetectable		 3ko0K-5olsA:
11.55
3ko0S-5olsA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 170
PHE A 159
GLY A 188
PHE A 141
 None
 1.06A 3ko0R-5olsA:
undetectable
3ko0T-5olsA:
undetectable		 3ko0R-5olsA:
11.55
3ko0T-5olsA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 102
MET A  90
SER A 134
LEU A 136
 None
 1.07A 3lsfH-5olsA:
undetectable		 3lsfH-5olsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 216
GLY A 218
SER A 245
ALA A 198
ASN A 201
 None
 1.29A 3t7sA-5olsA:
undetectable		 3t7sA-5olsA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 216
GLY A 218
SER A 245
ALA A 198
ASN A 201
 None
 1.29A 3t7sB-5olsA:
undetectable		 3t7sB-5olsA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 216
GLY A 218
SER A 245
ALA A 198
ASN A 201
 None
 1.28A 3t7sC-5olsA:
undetectable		 3t7sC-5olsA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 216
GLY A 218
SER A 245
ALA A 198
ASN A 201
 None
 1.28A 3t7sD-5olsA:
undetectable		 3t7sD-5olsA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 316
ALA A 313
ARG A 240
ALA A 241
 None
 1.11A 3twpB-5olsA:
undetectable		 3twpB-5olsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 316
ALA A 313
ARG A 240
ALA A 241
 None
 1.01A 3twpC-5olsA:
undetectable		 3twpC-5olsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A 133
LEU A 136
ASN A 135
GLU A  95
 None
 1.01A 3zqtA-5olsA:
undetectable		 3zqtA-5olsA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A 326
GLY A 287
ALA A 286
GLU A 307
 None
 0.93A 4ae1A-5olsA:
undetectable		 4ae1A-5olsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 217
TYR A 199
ASP A 215
ASP A 250
GLY A 283
 None
None
CA  A 601 (-2.1A)
AQA  A 606 ( 3.1A)
None
 1.47A 4j7xF-5olsA:
undetectable		 4j7xF-5olsA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 209
GLY A 211
GLY A 212
GLU A 207
GLN A 155
 None
None
CA  A 602 (-4.1A)
None
RAM  A 605 ( 3.3A)
 1.12A 4l8fD-5olsA:
undetectable		 4l8fD-5olsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 286
ALA A 337
GLY A 320
PHE A 284
TYR A 344
 None
 1.19A 4r29C-5olsA:
undetectable		 4r29C-5olsA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A 231
VAL A 258
PHE A 183
ILE A 193
 None
 1.09A 4xv2B-5olsA:
undetectable		 4xv2B-5olsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A 276
GLY A 320
ARG A 319
GLY A 341
 None
None
GTR  A 608 (-3.0A)
None
 0.73A 5cdnR-5olsA:
undetectable
5cdnS-5olsA:
undetectable		 5cdnR-5olsA:
20.53
5cdnS-5olsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A 276
GLY A 320
ARG A 319
GLY A 341
 None
None
GTR  A 608 (-3.0A)
None
 0.95A 5cdnC-5olsA:
undetectable
5cdnD-5olsA:
undetectable		 5cdnC-5olsA:
20.53
5cdnD-5olsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  57
LEU A  47
TYR A  67
PHE A 129
ILE A 144
 None
 1.07A 5fsaB-5olsA:
undetectable		 5fsaB-5olsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 269
GLN A 155
GLY A 248
ASP A 250
THR A 282
 None
RAM  A 605 ( 3.3A)
None
AQA  A 606 ( 3.1A)
None
 1.26A 5hg0A-5olsA:
undetectable		 5hg0A-5olsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 173
ILE A 161
GLU A 157
PHE A 159
VAL A 128
 None
 1.21A 5igzA-5olsA:
undetectable		 5igzA-5olsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 7 ASP A 247
GLY A 248
ASP A 246
HIS A 220
ASP A 250
 CA  A 601 ( 3.3A)
None
CA  A 602 (-2.5A)
RAM  A 605 ( 3.6A)
AQA  A 606 ( 3.1A)
 1.45A 5no9D-5olsA:
undetectable		 5no9D-5olsA:
10.44