SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5olt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5olt -
(-) 		4 / 8 MET A 323
ARG A 337
PHE A 332
LEU A 286
 None
 1.30A 1ea1A-5oltA:
undetectable		 1ea1A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5olt -
(-) 		5 / 12 PHE A 425
LEU A 245
PHE A 264
TRP A 261
ALA A 470
 None
 1.06A 1fe2A-5oltA:
undetectable		 1fe2A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5olt -
(-) 		5 / 12 PHE A 425
LEU A 245
PHE A 264
TRP A 261
ALA A 470
 None
 1.00A 1igxA-5oltA:
undetectable		 1igxA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5olt -
(-) 		5 / 12 LEU A 267
GLY A 471
VAL A 438
LEU A 260
LEU A 245
 None
 1.44A 1nhzA-5oltA:
undetectable		 1nhzA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5olt -
(-) 		5 / 9 ALA A 414
PHE A 418
GLY A 254
ALA A 253
LEU A 245
 None
 0.99A 1nr6A-5oltA:
undetectable		 1nr6A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5olt -
(-) 		5 / 10 LEU A 245
ALA A 414
LEU A 255
MET A 256
LEU A 447
 None
 1.18A 1pcgB-5oltA:
undetectable		 1pcgB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 12 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.32A 1q23A-5oltA:
undetectable
1q23B-5oltA:
undetectable		 1q23A-5oltA:
undetectable
1q23B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 12 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.33A 1q23B-5oltA:
undetectable		 1q23B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 12 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.24A 1q23C-5oltA:
undetectable		 1q23C-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 12 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.30A 1q23D-5oltA:
undetectable
1q23E-5oltA:
undetectable		 1q23D-5oltA:
undetectable
1q23E-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 10 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.31A 1q23E-5oltA:
undetectable		 1q23E-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 11 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.27A 1q23F-5oltA:
undetectable		 1q23F-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 11 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.36A 1q23G-5oltA:
undetectable		 1q23G-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 11 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.30A 1q23I-5oltA:
undetectable		 1q23I-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 10 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.32A 1q23K-5oltA:
undetectable		 1q23K-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 11 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.17A 1q23L-5oltA:
undetectable		 1q23L-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q72_H_COCH401_1
(FAB M82G2, HEAVY
CHAIN
FAB M82G2, LIGHT
CHAIN)		 5olt -
(-) 		5 / 10 ASN A 241
VAL A 336
GLY A 340
HIS A 295
TYR A 299
 None
 1.49A 1q72H-5oltA:
undetectable
1q72L-5oltA:
undetectable		 1q72H-5oltA:
undetectable
1q72L-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5olt -
(-) 		3 / 3 ASP A 367
PHE A 418
ASN A 241
 None
 0.68A 1sg9B-5oltA:
undetectable		 1sg9B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5olt -
(-) 		5 / 11 VAL A 440
VAL A 438
ASN A 241
GLU A 442
LEU A 286
 None
None
None
ZN  A 601 (-2.6A)
None
 0.98A 1t6zA-5oltA:
undetectable		 1t6zA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5olt -
(-) 		4 / 4 ASP A 366
LEU A 421
LEU A 417
LEU A 368
 None
 1.39A 1u18A-5oltA:
undetectable		 1u18A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 5olt -
(-) 		5 / 10 ALA A 496
VAL A 438
VAL A 440
PRO A 441
VAL A 472
 None
 1.02A 2nnjA-5oltA:
undetectable		 2nnjA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5olt -
(-) 		4 / 8 SER A 278
SER A 244
HIS A 443
ARG A 458
 ZN  A 601 ( 2.0A)
ZN  A 601 ( 4.4A)
ZN  A 601 (-3.2A)
CIT  A 603 (-3.0A)
 1.22A 2vmyA-5oltA:
undetectable
2vmyB-5oltA:
undetectable		 2vmyA-5oltA:
undetectable
2vmyB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5olt -
(-) 		4 / 8 ASN A 399
VAL A 364
TYR A 410
ASN A 391
 None
 1.20A 2wekA-5oltA:
undetectable		 2wekA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5olt -
(-) 		4 / 8 ASN A 399
VAL A 364
TYR A 410
ASN A 391
 None
 1.19A 2wekB-5oltA:
undetectable		 2wekB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5olt -
(-) 		5 / 12 THR A 466
GLY A 274
SER A 273
ALA A 281
VAL A 537
 None
 0.97A 2yvlA-5oltA:
undetectable		 2yvlA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5olt -
(-) 		5 / 12 THR A 466
GLY A 274
SER A 273
ALA A 281
ALA A 528
 None
 1.15A 2yvlC-5oltA:
undetectable		 2yvlC-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5olt -
(-) 		5 / 12 LEU A 245
ALA A 414
LEU A 255
MET A 256
LEU A 447
 None
 1.26A 3olsB-5oltA:
undetectable		 3olsB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5olt -
(-) 		3 / 3 ARG A 433
LEU A 375
THR A 388
 None
 0.90A 3oxcA-5oltA:
undetectable		 3oxcA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5olt -
(-) 		4 / 6 VAL A 538
ASN A 272
TYR A 557
ILE A 465
 None
 1.16A 3q5sA-5oltA:
undetectable		 3q5sA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 12 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.17A 3u9fH-5oltA:
undetectable
3u9fI-5oltA:
undetectable		 3u9fH-5oltA:
undetectable
3u9fI-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5olt -
(-) 		5 / 12 THR A 222
SER A 289
LEU A 285
VAL A 440
PHE A 271
 None
 1.17A 3u9fJ-5oltA:
undetectable
3u9fL-5oltA:
undetectable		 3u9fJ-5oltA:
undetectable
3u9fL-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5olt -
(-) 		5 / 11 LEU A 285
PHE A 224
VAL A 239
LEU A 237
PHE A 389
 None
 1.05A 3w67A-5oltA:
undetectable		 3w67A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5olt -
(-) 		5 / 12 LEU A 285
PHE A 224
VAL A 239
LEU A 237
PHE A 389
 None
 1.11A 3w68A-5oltA:
undetectable		 3w68A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5olt -
(-) 		4 / 7 ILE A 283
LEU A 286
GLY A 341
GLY A 340
 None
 0.68A 5a06B-5oltA:
undetectable		 5a06B-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5olt -
(-) 		5 / 10 LEU A 245
ALA A 414
LEU A 255
MET A 256
LEU A 447
 None
 1.22A 5dxbA-5oltA:
undetectable		 5dxbA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5olt -
(-) 		5 / 10 LEU A 245
ALA A 414
LEU A 255
MET A 256
LEU A 447
 None
 1.23A 5hyrA-5oltA:
undetectable		 5hyrA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5olt -
(-) 		5 / 10 ALA A 496
ILE A 497
TYR A 494
PHE A 268
VAL A 472
 None
 1.24A 5i6xA-5oltA:
undetectable		 5i6xA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5olt -
(-) 		4 / 7 SER A 244
HIS A 443
GLY A 444
LEU A 393
 ZN  A 601 ( 4.4A)
ZN  A 601 (-3.2A)
None
None
 0.98A 6btxA-5oltA:
undetectable		 6btxA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5olt -
(-) 		5 / 10 VAL A 250
ALA A 253
LEU A 245
LEU A 395
LEU A 421
 None
 0.98A 6f6nA-5oltA:
undetectable
6f6nB-5oltA:
undetectable		 6f6nA-5oltA:
undetectable
6f6nB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5olt -
(-) 		4 / 6 VAL A 250
LEU A 245
LEU A 395
LEU A 421
 None
 0.94A 6f6sA-5oltA:
undetectable
6f6sB-5oltA:
undetectable		 6f6sA-5oltA:
undetectable
6f6sB-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5olt -
(-) 		5 / 11 SER A 531
GLY A 444
ASP A 249
LEU A 447
ASP A 450
 None
 1.18A 6i5zD-5oltA:
undetectable		 6i5zD-5oltA:
undetectable