SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5omm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 GLY A 453
SER A 401
ILE A 446
LEU A 399
 None
 0.92A 1jg4A-5ommA:
undetectable		 1jg4A-5ommA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 TRP A 381
GLU A 359
TYR A 335
 None
 1.04A 2a3aA-5ommA:
undetectable		 2a3aA-5ommA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 SER A 240
PHE A 442
LEU A 505
LEU A 229
 None
 0.99A 2bfpA-5ommA:
undetectable		 2bfpA-5ommA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 SER A 240
PHE A 442
LEU A 505
LEU A 229
 None
 0.99A 2bfpD-5ommA:
undetectable		 2bfpD-5ommA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 SER A 387
VAL A 386
ARG A 356
ILE A 338
PHE A 378
 EDO  A 603 (-3.9A)
None
None
None
None
 1.47A 2vdyA-5ommA:
undetectable		 2vdyA-5ommA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 SER A 387
VAL A 386
ARG A 356
ILE A 338
PHE A 378
 EDO  A 603 (-3.9A)
None
None
None
None
 1.41A 2vdyB-5ommA:
undetectable		 2vdyB-5ommA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		4 / 4 LEU A 460
ASP A 269
VAL A 466
THR A 276
 None
 1.23A 3cyxB-5ommA:
undetectable		 3cyxB-5ommA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ASN A 502
HIS A 500
VAL A 433
 None
 0.80A 3elzB-5ommA:
undetectable		 3elzB-5ommA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		4 / 4 ILE A 338
GLN A 340
VAL A 386
PHE A 378
 None
 1.19A 3ieoA-5ommA:
undetectable		 3ieoA-5ommA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 5omm CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 GLU A 255
GLN A 410
ARG A 443
ILE A 446
LEU A 448
 None
 1.50A 4k38A-5ommA:
undetectable
4k38D-5ommA:
undetectable		 4k38A-5ommA:
20.90
4k38D-5ommA:
5.63